A5100397440- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Renal and related cancers
- Infant Nutrition and Health
- Infant Development and Preterm Care
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Inflammatory Biomarkers in Disease Prognosis
- Genomics, phytochemicals, and oxidative stress
- Nitric Oxide and Endothelin Effects
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Caveolin-1 and cellular processes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Axon Guidance and Neuronal Signaling
- Cancer, Lipids, and Metabolism
- Connective tissue disorders research
- Cancer, Hypoxia, and Metabolism
- Synthesis and biological activity
- Histone Deacetylase Inhibitors Research
Shanghai University of Medicine and Health Sciences
2025
University of Fribourg
2023-2025
Second Affiliated Hospital of Nanjing Medical University
2014-2024
Nanjing Children's Hospital
2014-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
Icahn School of Medicine at Mount Sinai
2023
Nanjing Medical University
2017-2023
University of Calgary
2023
Nanjing Maternity and Child Health Care Hospital
2021-2023
Harbin Medical University
2023
// Cuiling Qi 1, * , Bo Wei 2, Weijie Zhou 3, Yang 1 Bin Li Simei Guo Jialin Jie Ye Jiangchao Qianqian Zhang Tian Lan Xiaodong He Liu Cao 4 Jia 5 Jianguo Geng 3 Lijing Wang Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, 510006, China 2 Department of Gastrointestinal Surgery, The Third Affiliated Hospital, Sun Yat-sen 510630, Biologic and Materials Sciences, University Michigan School Dentistry, Ann Arbor, 48109, USA Key Laboratory Medical Cell Biology,...
Non-small-cell lung cancer (NSCLC) accounts for up to 80-85% of all cancers and has a disappointing prognosis. Flavonoids exert anticancer properties, mostly involving stimulation ROS production without significant toxicity normal cells. This study was aimed delineate the effect diosmetin, natural flavonoid, on NSCLC cells its ability enhance antitumour activity paclitaxel.
Slit is a secreted protein known to function through the Roundabout (Robo) receptor as repellent for axon guidance and neuronal migration, an inhibitor in leukocyte chemotaxis. We have previously shown that Slit2 also by variety of human cancer cells whereby it acts chemoattractant vascular endothelial tumor angiogenesis. used blocking antibody investigate role Slit–Robo signaling angiogenesis during oral carcinogenesis. In this report we undertook multistage model...
Studies have indicated that platelets play an important role in tumorigenesis, and abundance of accumulate the ovarian tumor microenvironment outside vasculature.However, whether cancer cells recruit within intestinal tumors how they signal adherent to enter tissues remain unknown.Here, we unexpectedly found large numbers were deposited human colorectal specimens using immunohistochemical staining, these fully associated with development.We further report robust adhesion platelet aggregates...
Due to huge economic losses the dairy industry worldwide, mastitis can be considered as one of most common diseases in cows. This work aimed study this disease by comparing multiple biological specimens (feces, serum, and urine) from individuals with or without clinical mastitis. was performed a single analytical platform, namely 1H-NMR, through multi-matrix strategy. Thanks high reproducibility we could characterize 120 molecules across cow feces, urine. Among them, 23 were three biofluids....
Background Aberrant mitochondrial metabolism is a key source of massive reactive oxygen species (mtROS) in tumour cells. Arginase-II (Arg-II), widely expressed metabolic enzyme, has recently been shown to enhance mtROS production and melanoma progression. However, how Arg-II enhances whether involved stimulation cancer cell proliferation migration remain unclear. Methods results Here, we show that ablation arg-ii suppresses growth, migration, nuclear deformation, DNA damage Vice versa,...
// Cuiling Qi 1,* , Qin Zhou Bin Li 1 Yang Liu Cao 4 Yuxiang Ye Jiangchao Yi Ding Huiping Wang Jintao Xiaodong He Qianqian Zhang Tian Lan Kenneth Ka Ho Lee 3 Weidong Xiaoyu Song Jia 5 Xuesong 2 and Lijing Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, China Key Laboratory for Regenerative Medicine of the Ministry Education, Division Histology & Embryology, Medical College, Jinan School Biomedical Sciences, Chinese University Hong Kong, Shatin, Cell...
Studies have indicated that the aggregation of activated platelets with cancer cells facilitates tumor metastasis; adhesion molecule P-selectin may be an important mediator this process, but detailed mechanism is unclear. In current study, we established a B16F10 (B16) cell metastatic model in knockout (P-sel-/-) mice to determine effect P-selectin-mediated platelet on metastasis. Compared C57 mice, P-sel-/- developed fewer foci, and proliferation within tumors was inhibited by deficiency....
Although survival rate of infants born prematurely has been raised by supplemental oxygen treatment, it is followed high morbidity hyperoxia-induced bronchopulmonary dysplasia. In this study, the effect resveratrol on lung injury was evaluated in hyperoxia-exposed rats preterm birth. The results demonstrated that hyperoxia led to thickened alveolar wall, simplified architecture and fibrosis. addition, elevated methane dicarboxylic aldehyde level, decreased glutathione level superoxide...
Abstract Drug repurposing of non-cancer drugs represents an attractive approach to develop new cancer therapy. Using the TRAMP transgenic mouse model, glipizide, a widely used drug for type 2 diabetes mellitus, has been identified suppress prostate (PC) growth and metastasis. Angiogenesis is intimately associated with various human developments. Intriguingly, glipizide significantly reduces microvessel density in PC tumor tissues, while not inhibiting cell proliferation from MTT assay flow...
Introduction: Vitamin D deficiency and inflammation are involved with bronchopulmonary dysplasia (BPD) in preterm neonates; however, the clinical evidence still remains scarce. We hypothesized that vitamin inflammatory cytokines may be risk factors for BPD infants. Methods: Preterm infants born between 28 31 weeks' gestation were recruited January 2016 2017. Blood samples all collected at corresponding time points. was measured using an automatic biochemical analyzer, (TNF-α, IL-1β, IL-6,...
Alveolar epithelial cell (AEC) senescence-induced changes of lung mesenchymal cells are key to starting the progress pulmonary fibrosis. Follistatin-like 1 (FSTL1) plays a central regulatory role in complex process senescence and fibrosis by enhancing transforming growth factor-β1 (TGF-β1) signal pathway activity. Activation Smad4 Ras relies on SUMO-specific peptidase (SENP1)-mediated deSUMOylation during TGF-β signaling activation. We hypothesized that SENP1-mediated may be potential...
Abstract Elevated arginases including type‐I (Arg‐I) and type‐II isoenzyme (Arg‐II) are reported to play a role in aging, age‐associated organ inflammaging, fibrosis. A of arginase pulmonary aging underlying mechanisms not explored. Our present study shows increased Arg‐II levels lung female mice, which is detected bronchial ciliated epithelium, club cells, alveolar type 2 (AT2) pneumocytes, fibroblasts (but vascular endothelial smooth muscle cells). Similar cellular localization also...
Bronchopulmonary dysplasia (BPD), associated with chorioamnionitis, results from the simultaneous effects of disrupted lung development, injury, and repair superimposed on developing lung. Caveolins (Cavs) are implicated as major modulators injury remodeling by multiple signaling pathways, although Cavs have been minimally studied in injured We hypothesized that chorioamnionitis-associated antenatal inflammation would decrease expression Cav-1 preterm fetal lungs. tested whether changes...
Osteosarcoma (OS) is a hyperproliferative malignant tumor that requires high vascular density to maintain its large volume. Vascular Endothelial Growth Factor (VEGF) plays crucial role in angiogenesis and acts as paracrine autocrine agent affecting both endothelial cells. The alpha-Ca2+/Calmodulin kinase two (α-CaMKII) protein an important regulator of OS growth. Here, we investigate the α-CaMKII-induced VEGF growth tumorigenicity OS. We show pharmacologic genetic inhibition α-CaMKII results...
Summary Pulmonary surfactant, a unique developmentally regulated, phospholipid‐rich lipoprotein, is synthesized by the type II epithelial cells (AECII) of pulmonary alveolus, where it stored in organelles termed lamellar bodies. The synthesis surfactant under multifactorial control and regulated number hormones factors, including glucocorticoids, prolactin, insulin, growth estrogens, androgens, thyroid hormones, catecholamines acting through beta‐adrenergic receptors, cAMP. While there...