A5000340215- Immune cells in cancer
- Cardiac Imaging and Diagnostics
- Energy and Environment Impacts
- 3D Shape Modeling and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Advanced Vision and Imaging
- Energy, Environment, and Transportation Policies
- Advanced X-ray and CT Imaging
- 3D Surveying and Cultural Heritage
- Computer Graphics and Visualization Techniques
- Mesenchymal stem cell research
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Histone Deacetylase Inhibitors Research
- Monetary Policy and Economic Impact
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
- MRI in cancer diagnosis
- Angiogenesis and VEGF in Cancer
- Viral Infections and Immunology Research
- Axon Guidance and Neuronal Signaling
- Tissue Engineering and Regenerative Medicine
- Image Processing and 3D Reconstruction
Group Sense (China)
2022-2025
University of the Witwatersrand
2023-2024
Guangdong Pharmaceutical University
2014-2023
Wenzhou University
2023
Wenzhou University of Technology
2023
Hangzhou Dianzi University
2022
Weatherford College
2022
University of Pretoria
2011-2021
Center for Systems Biology
2014-2021
Harvard University
2014-2021
Rationale: The mechanisms leading to an expanded neutrophil and monocyte supply after stroke are incompletely understood. Objective: To test the hypothesis that transient middle cerebral artery occlusion (tMCAO) in mice leads activation of hematopoietic bone marrow stem cells. Methods Results: Serial vivo bioluminescence reporter gene imaging with tMCAO revealed cell cycling peaked 4 days ( P <0.05 versus pre tMCAO). Flow cytometry cycle analysis showed entire tree, including myeloid...
Abstract Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring patients. Here we describe positron emission tomography (PET) imaging with 18 F-Macroflor, a modified polyglucose nanoparticle high avidity for macrophages. Due its small size, Macroflor is excreted renally, prerequisite the isotope flourine-18....
Macrophages play a central role in the pathogenesis of atherosclerosis. The inflammatory properties these cells are dictated by their metabolism, which mechanistic target rapamycin (mTOR) signaling pathway is key regulator. Using myeloid cell-specific nanobiologics apolipoprotein E-deficient (Apoe-/-) mice, we found that targeting mTOR and ribosomal protein S6 kinase-1 (S6K1) pathways rapidly diminished plaque macrophages' activity. By investigating transcriptome modifications, identified...
ABSTRACT Background & Aims Microvascular invasion (MVI) is associated with poor prognosis in hepatocellular carcinoma (HCC). Topology may improve the predictive performance and interpretability of deep learning (DL). We aimed to develop externally validate an MRI‐based topology DL model for preoperative prediction MVI. Methods This dual‐centre retrospective study included consecutive surgically treated HCC patients from two tertiary care hospitals. Automatic liver tumour segmentations...
Local plaque macrophage proliferation and monocyte production in hematopoietic organs promote progression of atherosclerosis. Therefore, noninvasive imaging could serve as a biomarker monitor therapeutic intervention.
// Cuiling Qi 1,* , Qin Zhou Bin Li 1 Yang Liu Cao 4 Yuxiang Ye Jiangchao Yi Ding Huiping Wang Jintao Xiaodong He Qianqian Zhang Tian Lan Kenneth Ka Ho Lee 3 Weidong Xiaoyu Song Jia 5 Xuesong 2 and Lijing Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, China Key Laboratory for Regenerative Medicine of the Ministry Education, Division Histology & Embryology, Medical College, Jinan School Biomedical Sciences, Chinese University Hong Kong, Shatin, Cell...
Monocytes and macrophages are indispensable in the healing process after myocardial infarction (MI); however, spatiotemporal distribution of monocyte infiltration its correlation to prognostic indicators reperfused MI have not been well described.With combined fluorine 19/proton ((1)H) magnetic resonance imaging, we noninvasively visualized recruitment monocytes vivo a rat model MI. Blood were labeled by intravenous injection (19)F-perfluorocarbon emulsion 1 day The patterns correlated...
Atherosclerosis is known to impair vascular function and cause stiffening. The aim of this study was evaluate the potential predictive role stiffening in early detection atherosclerosis. Therefore, we investigated time course functional morphological alterations vessel wall a murine atherosclerosis model. Because initial lesions are distributed inhomogeneously early-stage atherosclerosis, MR microscopy performed measure elasticity locally, specifically local pulse wave velocity arterial...
MicroRNAs (miRNAs) are short RNA molecular fragments that regulate gene expression by targeting and inhibiting the of specific RNAs. Due to fact microRNAs affect many diseases in microbial ecology, it is necessary predict microRNAs' association with at level. To this end, we propose a novel model, termed as GCNA-MDA, where dual-autoencoder graph convolutional network (GCN) integrated miRNA-disease association. The proposed method leverages autoencoders extract robust representations miRNAs...
Background Oncolytic virotherapy of tumors is an up-coming, promising therapeutic modality cancer therapy. Unfortunately, non-invasive techniques to evaluate the inflammatory host response treatment are rare. Here, we 19F magnetic resonance imaging (MRI) which enables visualization processes in pathological conditions by use perfluorocarbon nanoemulsions (PFC) for monitoring oncolytic virotherapy. Methodology/Principal Findings The Vaccinia virus strain GLV-1h68 was used as agent different...
Alzheimer's disease (AD) is a progressive neurological disorder that primarily affects memory, and its prevalence rising. Increasing evidence suggests dysfunction of the blood-brain barrier (BBB) may be involved in AD other neurodegenerat
Analyses of residential electricity demand primarily rely on expenditure or aggregate data. However, newer sources data, such as that from meter readings, are becoming available. In most circumstances, these cannot be matched to detailed information about the household. this research, we make use South Africa's Domestic Electrical Load Study, one only available in a developing country includes both and household level Due some gaps focus our attention average peak consumption, estimating...
As a revolutionary design approach, generative could offer promising solutions for intelligent design. Considering the high expenses and poor efficiency inherent in traditional interior design, this paper proposes customized style (CSID) framework based on Generative Adversarial Network (GAN). The CSID-GAN is two-stage model that first generate rational layout schemes then personalize to achieve desired outcomes. To end, various loss functions are incorporated train different tasks....
Human's sketch understanding is important. It has many applications in human computer interaction, multimedia, and vision. Recognizing sketches also challenging. Previous methods focus on single-object recognition. Understanding human's scene that involves multiple objects their complex interactions not been explored. In this paper, we tackle new problem. We create the first dataset "Scene250" propose a deep learning method to understand sketches. "Scene-Net", convolutional neural network...
Background The aim of this study was to investigate the influence convolution kernel and iterative reconstruction on diagnostic performance radiomics deep learning (DL) in lung adenocarcinomas. Methods A total 183 patients with 215 adenocarcinomas were included study. All CT imaging data reconstructed three algorithms (ASiR at 0%, 30%, 60% strength), each two kernels (bone standard). 171 nodules selected as training‐validation set, whereas 44 testing set. Logistic regression a DL...
Abstract P-selectin glycoprotein ligand 1 (SELPLG/PSGL-1) is an inflammatory molecule that functionally related to immune cell differentiation and leukocyte mobilization. However, the role of PSGL-1 in tumor development remains unknown. Therefore, this study investigates mechanistic intestinal tumors colorectal cancer. ApcMin/+ mice are highly susceptible spontaneous adenoma formation, were crossbred with PSGL1-null generate compound transgenic a ApcMin/+;PSGL-1−/− genotype. The incidence...