A5000096833- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Product Development and Customization
- NMR spectroscopy and applications
- Design Education and Practice
- Electron Spin Resonance Studies
- Advanced Neuroimaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced NMR Techniques and Applications
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Service and Product Innovation
- Cardiac Fibrosis and Remodeling
- Cerebrovascular and Carotid Artery Diseases
- Manufacturing Process and Optimization
- Medical Imaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- S100 Proteins and Annexins
- ECG Monitoring and Analysis
Universitätsklinikum Würzburg
2015-2024
Comprehensive Cancer Center Mainfranken
2016-2024
University of Würzburg
2009-2021
University Hospital and Clinics
2020
Comenius University Bratislava
2019-2020
TU Wien
1994-2017
Klinikum Würzburg Mitte
2017
Technical University of Munich
2011-2015
Deutsches Herzzentrum der Charité
2014
MRB Research Center for Magnetic Resonance Bavaria
2013
Abstract The purpose of this work was to develop high‐resolution cardiac magnetic resonance imaging techniques for the in vivo mouse model quantification myocardial function and mass. Eight male mice were investigated on a 7‐Tesla MRI scanner. High‐quality images multiple short axis slices (in‐plane resolution 117 μm 2 , slice thickness 1 mm) acquired with an ECG‐gated cine sequence. Left ventricular end‐diastolic end‐systolic volumes mass calculated from segmented volumes. There precise...
AimsUncertainty exists over the importance of device-detected short-duration atrial arrhythmias. Continuous diagnostics, through home monitoring (HM) technology (BIOTRONIK, Berlin, Germany), provides a unique opportunity to assess frequency and quantity fibrillation (AF) episodes defined as high-rate events (AHRE).
Abstract Radiofrequency (RF)‐related heating of cardiac pacemaker leads is a serious concern in magnetic resonance imaging (MRI). Recent investigations suggest such to be strongly dependent on an implant's position within the surrounding medium, but this issue currently poorly understood. In study, phantom measurements RF‐induced electric currents inside lead were performed investigate impact device and configuration amount MRI‐related at tip. Seven hundred twenty position/lead path...
A high-precision pressure probe is described which allows non-invasive online-monitoring of the water relations intact leaves. Real-time recording leaf status occurred by data transfer to an Internet server. The patch clamp measures attenuated pressure, Pp, a in response constant Pclamp. Pp sensed miniaturized silicone sensor integrated into device. magnitude dictated function leaf, Tf, volume and ultimately cell turgor Pc, as shown theoretically. power Tf=f(Pc) theoretically derived was...
T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-maintenance and foster tissue repair. Herein, we investigated whether heart-specific cells exert salutary or detrimental effects in the context myocardial infarction (MI), leading cause death worldwide. After screening more than 150 class-II-restricted epitopes, found that myosin heavy chain alpha (MYHCA) was dominant cardiac antigen triggering post-MI CD4+ activation mice. Transferred MYHCA614-629-specific...
Ga-[1,4,7,10-tetraazacyclododecane-N,N',N″,N'″-tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positive neuroendocrine tumors. SSTR also known to be expressed on macrophages, which play a major role in inflammatory processes walls coronary arteries and large vessels. Therefore, imaging expression has potential visualize vulnerable plaques. We assessed 68Ga-DOTATATE accumulation...
Identification of key molecular players in myocardial healing could lead to improved therapies, reduction scar formation, and heart failure after infarction (MI). We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved wound healing, may play an important role MI given prior clinical mouse model data.To determine whether truly causative relationship existed between FXIII activity we prospectively studied repair FXIII-deficient mice. All FXIII(-/-) FXIII(-)(/+) (FXIII...
The aim of this pilot-study was to evaluate changes in myocardial oxygenation and perfusion under pharmacological stress with dipyridamole (DIP) by means MRI. Twenty healthy volunteers were examined using a multi-echo gradient-echo sequence. differential signal response due the blood oxygen level dependent (BOLD) effect studied variable conditions supply caused vasodilator DIP. Unlike contrast agents (CA) methods, which require at least two injections CA DIP, presented methods only single...
Restitution kinetics and alternans of ventricular action potential duration (APD) have been shown to be important determinants cardiac electrical stability. In this study, we tested the hypothesis that APD restitution properties differ between normal diseased human myocardium.Monophasic potentials were recorded from right septum in 24 patients with structural heart disease (SHD) 12 without SHD. Standard dynamic relations constructed by plotting as a function preceding diastolic interval. The...
Abstract The purpose of this study was to assess the distribution RF‐induced E‐fields inside a gel‐filled phantom human head and torso compare results with temperature rise at tip straight conductive implant, specifically examining dependence on position implant gel. MRI experiments were performed in two different 1.5T MR systems same manufacturer. E‐field liquid assessed using custom measurement system. measured various positions orientations fluoroptic thermometry. show that local strength...
// Constantin Lapa 1, * , Theresa Reiter 2, 3, Malte Kircher 1 Andreas Schirbel Rudolf A. Werner Theo Pelzer 2 Carmen Pizarro 4 Dirk Skowasch Lena Thomas 5 Ulrike Schlesinger-Irsch 6 Daniel Ralph Bundschuh Wolfgang R. Bauer Florian C. Gärtner 5, Department of Nuclear Medicine, University Hospital Würzburg, Germany Internal 3 Comprehensive Heart Failure Center, Medicine II - Pneumology/Cardiology, Bonn, Radiology, These authors have contributed equally to this work Correspondence...
Article1 January 1948RHEUMATISM AND ARTHRITISPart IPHILIP S. HENCH, M.D., F.A.C.P., WALTER BAUER, EDWARD W. BOLAND, DARRELL C. CRAIN, RICHARD H. FREYBERG, WALLACE GRAHAM, F.R.C.P. (C), PAUL HOLBROOK, L. MAXWELL LOCKIE, CURRIER MCEWEN, F. ROSENBERG, ROBERT M. STECHER, F.A.C.P.PHILIP F.A.C.P.Search for more papers by this author, M.D.Search (C)Search authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-1-66 SectionsAboutPDF ToolsAdd to favoritesDownload...
Abstract Measurement of myocardial perfusion is important for the functional assessment heart in vivo. Our approach based on modification longitudinal relaxation time T1 induced by magnetic spin labeling endogenous water protons. Labeling performed selectively inverting magnetization within detection slice, and measured using a fast gradient echo MRI technique. As result blood flow, nonexcited spins enter which leads to an acceleration rate. Incorporating this phenomenon mathematical model...
Facilitated translocation of molecules through channels and pores is fundamental importance for transmembrane transport in biological systems. Several such systems have specific binding sites inside the channel, but a clear understanding how interaction between channel affects flow still missing. We present generic analytical treatment problem that relates molecular to first passage time across number particles channel. Both quantities depend different ways on properties. For idealized case...
Noninvasive imaging of atherosclerosis remains challenging in clinical applications. Here, we applied noninvasive molecular to detect vascular cell adhesion molecule-1 early and advanced atherosclerotic lesions apolipoprotein E-deficient mice.Ultrasmall superparamagnetic iron oxide particles functionalized with (P03011) or without (P3007) molecule-1-binding peptide were visualized by ultra high-field (17.6 T) magnetic resonance. Injection P03011 resulted a marked signal loss the aortic root...
Nuclear imaging of active plaques still remains challenging. Advanced atherosclerotic have a strong expression P-selectin by the endothelium overlying plaques, but not on inactive fibrous plaques. We proposed new approach for noninvasive in vivo characterization based (68)Ga-Fucoidan, which is polysaccharidic ligand with nanomolar affinity.(68)Ga-Fucoidan was tested its potential to discriminate vulnerable apolipoprotein E-deficient mice receiving high cholesterol diet positron emission...
PURPOSE: To validate a magnetic resonance (MR) imaging technique that is not first pass and reveals perfusion regional blood volume (RBV) in the intact rat. MATERIALS AND METHODS: Measurement of was based on perfusion-sensitive T1 relaxation after spin labeling water protons. RBV determined from steady-state measurements before administration an intravascular contrast agent. The colored microsphere used as reference method for measurement. maps were obtained with rats at rest during 3 mg...