A5037401323- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Neuroimaging Techniques and Applications
- Electron Spin Resonance Studies
- NMR spectroscopy and applications
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Atomic and Subatomic Physics Research
- Cardiac electrophysiology and arrhythmias
- MRI in cancer diagnosis
- Radiation Detection and Scintillator Technologies
- Cardiac Arrhythmias and Treatments
- Microfluidic and Bio-sensing Technologies
- Cardiac Fibrosis and Remodeling
- Ultrasound and Hyperthermia Applications
- Medical Imaging Techniques and Applications
- Advanced NMR Techniques and Applications
- Electrical and Bioimpedance Tomography
- Blood properties and coagulation
- Geomagnetism and Paleomagnetism Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
Fraunhofer Institute for Integrated Circuits
2016-2023
MRB Research Center for Magnetic Resonance Bavaria
2008-2017
University of Würzburg
2002-2013
Universitätsklinikum Würzburg
1996-2013
Center for Systems Biology
2011
Massachusetts General Hospital
2006-2009
Biotronik (Germany)
2009
Charité - Universitätsmedizin Berlin
2006
Center for Clinical Research (United States)
2006
University of Duisburg-Essen
2006
Background— Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disorder that causes sudden death and heart failure in the young. Clinical data suggest competitive sports may provoke ARVC susceptible persons. Genetically, loss-of-function mutations desmosomal proteins (plakophilin, desmoplakin, or plakoglobin) have been associated with ARVC. To test hypothesis reduced protein expression ARVC, we studied cardiac effects of heterozygous plakoglobin deficiency mice. Methods...
Abstract The purpose of this work was to develop high‐resolution cardiac magnetic resonance imaging techniques for the in vivo mouse model quantification myocardial function and mass. Eight male mice were investigated on a 7‐Tesla MRI scanner. High‐quality images multiple short axis slices (in‐plane resolution 117 μm 2 , slice thickness 1 mm) acquired with an ECG‐gated cine sequence. Left ventricular end‐diastolic end‐systolic volumes mass calculated from segmented volumes. There precise...
The purpose of this clinical trial was to investigate whether cardiovascular magnetic resonance imaging (CMR) using ferumoxytol (Feraheme™, FH), an ultrasmall superparamagnetic iron oxide nanoparticle (USPIO), allows more detailed characterization infarct pathology compared with conventional gadolinium-based necrosis/fibrosis in patients acute myocardial infarction. Fourteen who had experienced ST-elevation infarction were included study. Following coronary angiography, a first baseline...
Cardiovascular transgenic mouse models with an early phenotype or even premature death require noninvasive imaging methods that allow for accurate visualization of cardiac morphology and function. Thus the purpose our study was to assess feasibility magnetic resonance (MRI) characterize function mass in newborn, juvenile, adult mice. Forty-five C57bl/6 mice from seven age groups (3 days 4 mo after birth) were studied by MRI under isoflurane anesthesia. Electrocardiogram-gated cine performed...
Identification of key molecular players in myocardial healing could lead to improved therapies, reduction scar formation, and heart failure after infarction (MI). We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved wound healing, may play an important role MI given prior clinical mouse model data.To determine whether truly causative relationship existed between FXIII activity we prospectively studied repair FXIII-deficient mice. All FXIII(-/-) FXIII(-)(/+) (FXIII...
Abstract — The aim of this study was to assess the capability MRI characterize systolic and diastolic function in normal chronically failing mouse hearts vivo at rest during inotropic stimulation. Applying an ECG-gated FLASH-cine sequence, 7 T performed after administration 1.5 μg/g IP dobutamine. There a significant increase heart rate, cardiac output, ejection fraction decrease end-diastolic end-systolic left ventricular (LV) volumes ( P <0.01 each) mice In with failure due chronic...
Sphingosine-1-phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia-reperfusion injury, and ischemic preconditioning. The function of the sphingosine-1-phosphate receptor 1 (S1P1) vivo is unknown.Cardiomyocyte-restricted deletion S1P1 mice (S1P1 (α) (MHCC) (re)) resulted progressive cardiomyopathy, compromised response to dobutamine, premature death. Isolated cardiomyocytes from (re) revealed reduced diastolic systolic Ca(2+) concentrations that were secondary...
Abstract Measurement of myocardial perfusion is important for the functional assessment heart in vivo. Our approach based on modification longitudinal relaxation time T1 induced by magnetic spin labeling endogenous water protons. Labeling performed selectively inverting magnetization within detection slice, and measured using a fast gradient echo MRI technique. As result blood flow, nonexcited spins enter which leads to an acceleration rate. Incorporating this phenomenon mathematical model...
HILLER, K.H., CALIFORNIA RESEARCH CORP., LA HABRA, CALIF. Abstract A rotational viscometer has been designed which permits the measurement of rheological properties drilling muds and other non-Newtonian fluids under conditions equivalent to those in a deep borehole (350F, 10,000 psi). The important mechanical features this instrument are described, its design criteria discussed. flow equations for novel configuration derived calibration procedures described.The date their interpretation,...
PURPOSE: To validate a magnetic resonance (MR) imaging technique that is not first pass and reveals perfusion regional blood volume (RBV) in the intact rat. MATERIALS AND METHODS: Measurement of was based on perfusion-sensitive T1 relaxation after spin labeling water protons. RBV determined from steady-state measurements before administration an intravascular contrast agent. The colored microsphere used as reference method for measurement. maps were obtained with rats at rest during 3 mg...
Abstract The effect of perfusion on relaxation time in tissue has only been considered for first‐pass kinetics NMR‐signal after application contrast agents. importance not yet studied steady state conditions, i.e., when the intravascular rate is constant time. aim this study to develop a model which T, derived as function and intracap‐illary volume fraction ( regional blood ). Tissue be two‐compartment system, consists intracapillary extravascular space. Intracapillary differs from arterial...
Abstract The absolute perfusion and the intracapillary or regional blood volume (RBV) in murine myocardium were assessed vivo by spin labeling magnetic resonance imaging. Pixel‐based RBV maps calculated at a pixel resolution of 469 × μm slice thickness 2 mm. T 1 imaging module was segmented inversion recovery snapshot fast low angle shot sequence with velocity compensation all three gradient directions. group average myocardial baseline determined to be 701 ± 53 mL (100 g · min) −1 for...
Monocytes and macrophages are indispensable in the healing process after myocardial infarction (MI); however, spatiotemporal distribution of monocyte infiltration its correlation to prognostic indicators reperfused MI have not been well described.With combined fluorine 19/proton ((1)H) magnetic resonance imaging, we noninvasively visualized recruitment monocytes vivo a rat model MI. Blood were labeled by intravenous injection (19)F-perfluorocarbon emulsion 1 day The patterns correlated...
The reduction in strength of porous Vycor glass caused by adsorption water vapor has been related to the lowering surface free energy, which obtained from measurements dimensional changes. Deviations this simple relationship have explained capillary condensation, causes a negative pressure under concave menisci completely filled pores. It shown that Griffith equation accounts quantitatively for observed weakening effect if is taken into account. data permit an estimate γ0=700∓100 erg/cm2...
Abstract The purpose of the present study was serial investigation morphological and functional changes after left coronary artery ligation in intact rat using cine‐magnetic resonance imaging (MRI). MRI studies were performed 4, 8, 12, 16 weeks myocardial infarction (MI) with an echocardiogram (ECG)‐triggered cine‐fast low‐angle shot (FLASH)‐sequence a 7‐Tesla magnet. MI‐size, ventricular (LV) mass volumes, cardiac index, ejection fraction (EF), remote wall scar thickness 11 Wistar rats...
Objective: Creatine kinase (CK) is responsible for the transport of high-energy phosphates in excitable tissue and central importance myocardial energy homeostasis. Significant changes energetics have been reported mice lacking various CK isoenzymes. Our hypothesis was that ablation isoenzymes leads to cardiac hypertrophy, impaired function, aggravation left ventricular remodeling post-myocardial infarction.
A decrease in the supply of ATP from creatine kinase (CK) system is thought to contribute evolution heart failure. However, previous studies on mice with a combined knockout mitochondrial and cytosolic CK (CK(-/-)) have not revealed overt left ventricular dysfunction. The aim this study was employ novel MRI techniques measure maximal myocardial velocity (V(max)) perfusion thus determine whether abnormalities phenotype existed CK(-/-) mice, both at baseline 4 wk after infarction (MI). As...
Abstract Marking and identification of materials is becoming increasingly important due to complex global resource supply chains. Luminescent particle‐based markers have come the forefront their small dimensions ability be integrated in diverse materials. However, light‐absorbing can hardly marked by these particles, thus leading insufficient recycling rates of, e.g., black plastics. In this work, microparticles with a unique magnetic fingerprint are tailored modification nanoparticle...
Abstract —The fractal nature of heterogeneity myocardial blood flow and its implications for the healthy diseased heart is not yet understood. The main hindrance investigation role in physiology pathophysiology that conventional methods determination perfusion have severe limitations concerning temporal spatial resolution invasiveness. In isolated rat hearts, we developed a nuclear magnetic resonance technique does depend on contrast agents which apparent longitudinal relaxation time made...
Apoptosis, an active process of cell self-destruction, is associated with myocardial ischemia. The redistribution phosphatidylserine (PS) from the inner to outer leaflet membrane early event in apoptosis. Annexin V, a protein high specificity and tight binding PS, was used identify localize apoptosis ischemic heart.Fluorescein-labeled annexin V has been routinely for assessment vitro. For detection vivo, positron emission tomography single-photon computed have shown be suitable tools. In...
Imaging of myocardial ablation lesions during electrophysiology procedures would enable superior guidance interventions and immediate identification potential complications. The aim this study was to establish clinically suitable MRI-based imaging techniques for intraprocedural lesion visualization in interventional electrophysiology.Interventional performed under magnetic resonance an animal model, using a custom setup including resonance-conditional catheters. Various pulse sequences were...
Alterations in the coronary circulation are important determinants of myocardial function. Few data available, however, about microvascular changes reactive hypertrophy. With MRI, serial determination microcirculation after infarction (MI) is feasible.We quantitatively determined perfusion and relative intracapillary blood volume using an MRI technique. Infarct size, mass, left ventricular volumes were with cine MRI. Rats investigated at 8, 12, 16 weeks MI (mean size 24.1+/-2.0%) or sham...