A5057494207- Characterization and Applications of Magnetic Nanoparticles
- Advanced MRI Techniques and Applications
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Dental Radiography and Imaging
- Medical Imaging Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Total Knee Arthroplasty Outcomes
- NMR spectroscopy and applications
- Insect and Pesticide Research
- Nerve Injury and Rehabilitation
- Orthodontics and Dentofacial Orthopedics
- Geomagnetism and Paleomagnetism Studies
- Advanced X-ray and CT Imaging
- Nanoparticle-Based Drug Delivery
- Insect and Arachnid Ecology and Behavior
- Microfluidic and Bio-sensing Technologies
- Nitric Oxide and Endothelin Effects
- Anesthesia and Pain Management
- Lanthanide and Transition Metal Complexes
- Iron oxide chemistry and applications
- Plant and animal studies
- Shoulder Injury and Treatment
- Lower Extremity Biomechanics and Pathologies
Fraunhofer Institute for Integrated Circuits
2016-2025
Johnson University
2022-2024
Rutgers, The State University of New Jersey
2022-2024
Yale University
2021-2023
Yale New Haven Hospital
2022
Hashemite University
2022
Rowan University
2022
Hackensack Meridian Health
2022
University Medical Center
2022
Rajarshee Chhatrapati Shahu Maharaj Government Medical College and CPR Hospital Kolhapur
2022
: Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain disability. The present study aimed at evaluating safety of a dose-escalation protocol intra-articular injected adipose-derived stromal cells (ASCs) patients knee OA, as well clinical efficacy secondary endpoint. A bicentric, uncontrolled, open phase I trial was conducted France Germany regulatory agency...
Background During the last years, 19F-MRI and perfluorocarbon nanoemulsion (PFC) emerged as a powerful contrast agent based MRI methodology to track cells visualize inflammation. We applied this new modality deep tissue abscesses during acute chronic phase of inflammation caused by Staphylococcus aureus infection. Methodology Principal Findings In study, murine thigh infection model was used induce abscess formation PFC or CLIO (cross linked ironoxides) administered 24 h after inoculation,...
Inflammation after myocardial infarction may explain failure of bone marrow cells to improve cardiac function in infarcted recipient hearts.
Nitric oxide (NO) exerts a wide range of cellular effects in the cardiovascular system. NO is short lived, but S-nitrosoglutathione (GSNO) functions as stable intracellular bioavailable pool. Accordingly, increased levels can facilitate NO-mediated processes, and conversely, catabolism GSNO by regulatory enzyme reductase (GSNOR) impair these processes. Because dysregulated GSNOR interfere with processes relevant to health, it follows that inhibition may be beneficial. However, effect on...
Background Recent studies have shown that human ferritin can be used as a reporter of gene expression for magnetic resonance imaging (MRI). Bacteria also encode three classes ferritin-type molecules with iron accumulation properties. Methods and Findings Here, we investigated whether these bacterial ferritins MRI genes which the is most suitable reporter. Bacterial were overexpressed in probiotic E. coli Nissle 1917. Cultures bacteria analyzed those generating highest contrast further tumor...
Abstract Marking and identification of materials is becoming increasingly important due to complex global resource supply chains. Luminescent particle‐based markers have come the forefront their small dimensions ability be integrated in diverse materials. However, light‐absorbing can hardly marked by these particles, thus leading insufficient recycling rates of, e.g., black plastics. In this work, microparticles with a unique magnetic fingerprint are tailored modification nanoparticle...
Magnetic particle spectroscopy (MPS) is used in this work to obtain a magnetic fingerprint signal from anisotropic supraparticles, i.e., microrods assembled superparamagnetic iron oxide nanoparticles. Exceeding its intended purpose of nanoparticle characterization for biomedical imaging, it shown that MPS capable resolving structural differences between the alignment individual nanoparticles and isotropic counterpart. Additionally, orientation-dependent variations supraparticles are...
NMR microscopy provides non-invasively distinct soft-tissue contrast in small biological samples. We were able to visualize the three-dimensional structure of honeybee brain its natural shape intact head capsule. Thus, addition acquiring detailed information about shapes and volumes different compartments, we show their relative orientations toward each other within Since was lightly fixed but not dehydrated, stayed attached capsule internal structures, experiments exhibited larger a more...
Identifying and ensuring the integrity of products plays an important role in today's globalized world. Miniaturized information taggants packaging surface are therefore required to monitor product itself instead applying external labels. Ideally, multiple types stored such additives. In this work, micrometer-sized core–shell particles (supraparticles) were developed provide material surfaces with both identifier a abrasion indication functionality. The core supraparticles contains iron...
The controlled agglomeration of superparamagnetic iron oxide nanoparticles (SPIONs) was used to rapidly switch their magnetic properties. Small-angle X-ray scattering (SAXS) and dynamic light showed that tailored with phase-changing organic ligand shells agglomerate at temperatures between 5 °C 20 °C. We observed the concurrent change in properties using particle spectroscopy (MPS) a temporal resolution on order seconds found reversible switching SPIONs by changing state. non-linear...
Circulating angiogenic cells (CACs) are peripheral blood whose functional capacity inversely correlates with cardiovascular risk and that have therapeutic benefits in animal models of disease. However, donor age disease state influence the efficacy autologous cell therapy. We sought to determine whether or coronary artery (CAD) impairs potential CACs for myocardial infarction (MI) use ex vivo gene therapy overexpress endothelial nitric oxide (NO) synthase (eNOS) overcomes these defects.
The development of effective recycling technologies is essential for the recovery and reuse raw materials required lithium-ion batteries (LIBs). Future processes depend on accessible information, necessitating implementation a digital battery passport. European regulation mandates use machine-readable identifier physically attached to accessing information. Since externally applied optical labels are vulnerable mechanical damage, identification without these restrictions could be beneficial....
The determination of induced mechanical forces in ball mills is an ongoing problem, which so far mainly addressed by simulations. Herein, we suggest utilizing superparamagnetic microballoons as sensor particles for stress. defined assembly nanoparticles yields with hollow cores, makes them susceptible to forces. It shown that the structure continuously fragmented under static or dynamic force application. By use magnetic particle spectroscopy, these structural changes are readily detected...
Pleiotrophin (PTN) is a growth factor with both pro-angiogenic and limited pro-tumorigenic activity. We evaluated the potential for PTN to be used safe angiogenic gene therapy using full length truncated variant lacking domain implicated in tumorigenesis. Mouse myoblasts were transduced express or (PTN T-PTN), along LacZ reporter gene, injected into mouse limb muscle myocardium. In cultured myoblasts, was expressed secreted via Golgi apparatus, but T-PTN not properly secreted. Nonetheless,...
Objectives: The precision of localizing the mandibular canal prior to surgical intervention depends on achievable resolution, whereas identification nerve image contrast. In our study, we developed new protocols based gradient and spin echo sequences. results from both sequences were quantitatively compared for their agreement identify most suitable approach. Methods: By limiting field view one side mandible, three-dimensional acquisitions with T1 weighted performed 0.5 × mm3 resolution...
Abstract Background Kava is an important neuroactive medicinal plant. While kava has a large global consumer footprint for its clinical and recreational use, factors related to use lack standardization the tissue-specific metabolite profile of constituents not well understood. Results Here we characterized metabolomic spatio-temporal characteristics tissues from roots stems using cross-platform metabolomics 3D imaging approach. Gas chromatography–mass spectrometry liquid revealed highest...
New multifunctional nanoparticles (NPs) that can be used as contrast agents (CA) in different imaging techniques, such photoluminescence (PL) microscopy and magnetic resonance (MRI), open new possibilities for medical imaging, e.g., the fields of diagnostics or tissue characterization regenerative medicine. The focus this study is on synthesis CaF 2 :(Tb 3+ ,Gd ) NPs. Fabricated a wet-chemical procedure, spherical NPs with diameter 5–10 nm show crystalline structure. Simultaneous doping...
Adipose tissue-derived stromal cells (ASCs) represent a capable source for cell-based therapeutic approaches. For monitoring application in vivo, magnetic resonance imaging (MRI) of labeled with iron oxide particles is common method. It the aim present study to analyze potential DNA damage, cytotoxicity and impairment functional properties human (h)ASCs after labeling citrate-coated very small superparamagnetic (VSOPs). Cytotoxic as well genotoxic effects procedure were measured unlabeled...