Dietary phenols are antioxidants with diverse physiological functions that beneficial for human health. The objective of this research work was to investigate antioxidant activity p-coumaric acid (p-CA) using four in vitro methods, the protective effects against oxidative stress PC12 cells, and hypolipidemic on High fat-diet (HFD) mice model. p-CA exhibited moderate selected assay. highest chelating at 50 μg/mL found be 52.22%. Pretreatment significantly enhanced cell viability suppressed...

Anacardium occidentale L. (Anacardiaceae) is used in South Cameroon as well other tropical countries by traditional practitioners a folk remedy for treatment of diabetes mellitus. We demonstrated the antidiabetic potential plant extracts n-streptozotocin diabetic rats. The aim current study was to investigate effects ethanol extract leaves A. on neonatal streptozotocin Two day old neonates were injected with 100 mg/kg streptozotocin. At end experimental period 30 days, reduction fasting...

The symbiotic community of microorganisms in the gut plays an important role health host. While many previous studies have been performed on interactions between microbiome and host mammals, fish are still lacking. In this study, we investigated changes intestinal pathogen susceptibility zebrafish (Danio rerio) following chronic antibiotics exposure. exposure assay was for 30 days using oxytetracycline (Otc), sulfamethoxazole/trimethoprim (Smx/Tmp), or erythromycin (Ery), which widely used...

Background: Acridine and thiourea derivatives are important compounds in medicinal chemistry due to their diverse biological properties including anticancer antimicrobial effects. However, literature reveals some side effects associated with use of acridines. It is suggested that hybrid molecules may reduce the enhance beneficial synergistic activity. The objectives present study synthesize evaluate new hybrids acridine thiosemicarbazides derivatives. Results: structures synthesized 4a–4e...

Canthin-6-one alkaloids have consistently attracted the interest of medicinal chemists due to their wide range promising bioactivities, including antitumor, antifungal, antibacterial, and antiviral properties. However, low natural abundance in plants has constrained further exploration potential bioactivities. This study reports a comprehensive synthesis canthin-6-one alkaloids, utilizing key Suzuki coupling Cu-catalyzed amidation reactions construct core scaffold. Derivatives were...

Hepatotoxicity, or liver damage, is caused by hepatotoxins, which may source from chemicals, dietary supplements, pharmaceutical drugs, and medicinal plants. Notably, numerous plants are used to alleviate illness, particularly in traditional systems of medicine, such as Ayurveda Traditional Chinese Medicine. These medicine have been implemented for centuries treating various ailments. Some serve hepatoprotectors against while others induce hepatotoxicity. Recent advances instrumentation...

Abstract Background Aconitum is an indispensable entity of the traditional medicine therapy in Ayurveda and Traditional Chinese (TCM), spite its known fatal toxicity characteristics. The prolonged use this drug, irrespective lethal effects, governed by practice effective detoxification processes that have been used for decades. However, processing methods TCM are different, no comparative study has carried out to evaluate their differences. objective present was carry chemical profiling...

Introduction Asparagus is esteemed in Traditional Chinese Medicine and Ayurveda, it commercially one of the most important drugs global herbal market. Comparative metabolite profiling different species would help determining similarities ascertain their validity for being used as substitutes each other. Laser microdissection (LMD) facilitates identification metabolites specific tissues, thus can aid exploration metabolic pathways target tissues. Objective To compare tissue-specific...

Swietenia macrophylla (SM) is a medicinally important plant found in tropical and subtropical regions of the world. The ethyl acetate fraction seeds S. (SMEAF) reported to exhibit potent anticancer, antitumor, anti-inflammatory antifeedant activities. Till date, there have been no studies on acute oral toxicity profile SM. objective present study was determine SMEAF evaluate in-vitro neuroprotective activity using primary neuronal cell cultures. In study, did not produce any lethal signs...

Cyperus rotundus L. is a plant species commonly found in both India and China. The caused destruction of this critical concern for agricultural produce. Nevertheless, it can serve as potential source the commercially important sesquiterpenoid (+)-nootkatone. present work describes comparative metabolite profiling (+)-nootkatone content determination rhizome samples collected from these two countries. Laser dissected tissues, namely, cortex, hypodermal fiber bundles, endodermis, amphivasal...

A surge in the number of anthropogenic pollutants has been caused by increasing industrial activities. Nanoplastics are spotlighted as a new aquatic pollutant that threat to microbes and larger organisms. Our previous study showed subinhibitory concentrations such phenol formalin act signaling molecules modulate global gene expression metabolism. In this study, we aimed investigate impact type contaminant, polystyrene (PS) nanoplastics, on key virulence factors zoonotic pathogen Edwardsiella...

Acorus calamus and its related species are of significant importance to the food fragrance industries due their varied applications. They also a cause critical concern toxic β-asarone content. Several toxicity cases have occurred high compositions in products. Hence, limits for use strictly regulated by Food Drug Administration, European Union, legislations different countries. The identification with lower content is great significance. In this report, metabolite profiles essential oil A....

Achyranthes bidentata and aspera are saponin steroid rich medicinal plants, used extensively for therapeutic treatments in Traditional Chinese Medicine (TCM) Ayurveda. A. is reported to be one of the rare exploited plant species that face issue being endangered. Finding qualitative substitute with identical phyto-constituents contributing similar composition pharmacological benefits will help reducing burden exploitation natural habitats such plants. In present study, a comparative...

In the present study, extraction and isolation of Pelargonidin, an anthocyanin compound from stem bark Ficus benghalensis are described. The study also involves evaluation effect Pelargonidin on phenotypic variations in zebra fish embryos. Extraction were carried out by employing liquid-liquid technique, phytochemical tests, column chromatography, UV FT-IR. embryo model, Paclitaxel was employed as a negative control. A series changes different stages embryonic development studied with...

1. Box-Behnken Design–Directed Optimization of Wickerhamomyces anomalus–Mediated Biotransformation Process to Enhance the Flavonoid Profile Polyherbal Extract Praveen Gaur, Sadish Shanmugam Journal Pharmaceutical Innovation CrossRef

Abstract Background Kava is an important neuroactive medicinal plant. While kava has a large global consumer footprint for its clinical and recreational use, factors related to use lack standardization the tissue-specific metabolite profile of constituents not well understood. Results Here we characterized metabolomic spatio-temporal characteristics tissues from roots stems using cross-platform metabolomics 3D imaging approach. Gas chromatography–mass spectrometry liquid revealed highest...

Curcuma longa L. is recognized for its therapeutic and culinary uses both in Ayurveda traditional Chinese medicine considered to be a boon mankind. It has been extensively studied benefits still continues an important drug with continued potential further exploration research. We the tissue-specific distribution of secondary metabolites establish validity use rhizome samples from India China, as substitutes each other, based upon their metabolite profiles curcumin contents. Laser...

We report herein the design and synthesis of a series novel acridine-triazole acridine-thiadiazole derivatives. The newly synthesized compounds key intermediates were all evaluated for their antitumor activities against human foreskin fibroblasts (HFF), gastric cancer cells-803 (MGC-803), hepatocellular carcinoma bel-7404 (BEL-7404), large cell lung cells (NCI-H460), bladder (T24). Most exhibited high levels activity MGC-803 T24 but low toxicity normal liver (LO2), effect was even better...

Abstract Serenoa repens (saw palmetto) berries are one of the most consumed medicinal herbs in United States and wild green variety is used initial therapy benign prostatic hyperplasia (BPH), globally. Use saw palmetto approved by German Commission E, several clinical trials underway for evaluation its efficacy. Exploitation habitats over foraging imperil this plant, which only grows wild. This first study, to propose use S . forma glauca (silver variety) as a qualitative substitute variety,...