A5036218484- DNA and Nucleic Acid Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA and protein synthesis mechanisms
- Phytochemistry and Biological Activities
- Protein Interaction Studies and Fluorescence Analysis
- Metal-Catalyzed Oxygenation Mechanisms
- HIV/AIDS drug development and treatment
- Pancreatitis Pathology and Treatment
- Click Chemistry and Applications
- Metal complexes synthesis and properties
- Chemical Synthesis and Analysis
- Natural Antidiabetic Agents Studies
- Plant-based Medicinal Research
- Protein Structure and Dynamics
- Free Radicals and Antioxidants
- Mass Spectrometry Techniques and Applications
- Crystallography and molecular interactions
- Biological Stains and Phytochemicals
- Bioactive Compounds and Antitumor Agents
- Morinda citrifolia extract uses
- Bioactive Natural Diterpenoids Research
- Synthesis and biological activity
- Apelin-related biomedical research
- Traditional and Medicinal Uses of Annonaceae
China Medical University
2025
First Hospital of China Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
State Ethnic Affairs Commission
2022-2025
Temple University
2018-2022
Guangxi University for Nationalities
2019-2022
Guangxi University of Chinese Medicine
2018-2019
Hong Kong Baptist University
2014-2018
Guangxi University
2018
Shanghai First People's Hospital
2017
Dietary phenols are antioxidants with diverse physiological functions that beneficial for human health. The objective of this research work was to investigate antioxidant activity p-coumaric acid (p-CA) using four in vitro methods, the protective effects against oxidative stress PC12 cells, and hypolipidemic on High fat-diet (HFD) mice model. p-CA exhibited moderate selected assay. highest chelating at 50 μg/mL found be 52.22%. Pretreatment significantly enhanced cell viability suppressed...
The purpose of this research was to investigate the chemical profile, nutritional quality, antioxidant and hypolipidemic effects Mexican chia seed oil (CSO) in vitro. Chemical characterization CSO indicated content α-linolenic acid (63.64% total fatty acids) be highest, followed by linoleic (19.84%), saturated (less than 11%). Trilinolenin (53.44% triacylglycerols (TAGs)) found highest among seven TAGs CSO. capacity CSO, evaluated with ABTS•+ DPPH• methods, showed mild when compared...
Abstract Trans -resveratrol is a natural stilbenoid possessing multifarious pharmacological benefits; however, when orally consumed, it rapidly metabolised by colonic microflora and converted to dihydro-resveratrol. Thus, this microbial metabolite of great therapeutic relevance. In the present study, upon oral administration dihydro-resveratrol (10–50 mg/kg), severity acute pancreatitis in cerulein-treated rats was significantly ameliorated as evidenced decreased α-amylase activities plasma...
The rapid ascension of immune checkpoint blockade treatments has placed an emphasis on the need for viable, robust, and noninvasive imaging methods proteins, which could be diagnostic value. Immunoconjugate-based positron emission tomography (immuno-PET) allows sensitive quantitative target levels promising potential evaluation proteins. However, advancement immuno-PET is currently limited by available tools, heavily rely full-length IgGs with Fc-mediated effects are heterogeneous mixtures...
Abstract We report the discovery of a facile peptide macrocyclization and stapling strategy based on fluorine thiol displacement reaction (FTDR), which renders class analogues with enhanced stability, affinity, cellular uptake, inhibition cancer cells. This approach enabled selective modification orthogonal fluoroacetamide side chains in unprotected peptides presence intrinsic cysteines. The identified benzenedimethanethiol linker greatly promoted alpha helicity variety substrates, as...
Canthin-6-one alkaloids have consistently attracted the interest of medicinal chemists due to their wide range promising bioactivities, including antitumor, antifungal, antibacterial, and antiviral properties. However, low natural abundance in plants has constrained further exploration potential bioactivities. This study reports a comprehensive synthesis canthin-6-one alkaloids, utilizing key Suzuki coupling Cu-catalyzed amidation reactions construct core scaffold. Derivatives were...
Seedpod, the nonedible portion of lotus (Nelumbo nucifera Gaertn.), was reported to be rich in polyphenols. The objective this study investigate major bioactive polyphenols seedpods. total polyphenol content (TPC) from ethanol extract seedpod (PELS) found 34.23 μg gallic acid equivalents (GAE)/mg extract. Four polyphenolic compounds were identified PELS, comprised one flavan-3-ol (catechin) and three flavonoids (kaemferol, quercetin hyperoside). In vitro antioxidant antiproliferative...
Acute pancreatitis is an inflammatory process originated in the pancreas; however, it often leads to systemic complications that affect distant organs. respiratory distress syndrome indeed predominant cause of death patients with severe acute pancreatitis. In this study, we aimed delineate ameliorative effect dihydro‐resveratrol, a prominent analog trans ‐resveratrol, against pancreatitis‐associated lung injury and underlying molecular actions. was induced rats repetitive injections cerulein...
A new lignan, vitexkarinol (1), as well a known neopaulownin (2), chalcone, 3-(4-hydroxyphenyl)-1-(2,4,6-trimethoxyphenyl)-2-propen-1-one (3), two dehydroflavones, tsugafolin (4) and alpinetin (5), dipeptides, aurantiamide acetate, sesquiterpene, vemopolyanthofuran, five carotenoid metabolites, vomifoliol, dihydrovomifoliol, dehydrovomifoliol, loliolide, isololiolide, were isolated from the leaves twigs of Vitex leptobotrys through bioassay-guided fractionation. The chalcone (3) was found to...
Raman and ir spectra are reported for diethyl phosphate [(CH3CH2O)2PO-2] isotopomers incorporating carbon-13 at methylene group sites [(CH133CH2O)2PO-2] deuterium substituents on methyl carbons [(CH3CD2O)2PO-2, (CD3CH2O)2PO-2 (CD3CD2O)2PO-2]. The vibrational analyzed to develop a consistent set of assignments the C-C-O-P(O-2)-O-C-C network, which serves as model nucleic acid phosphodiester backbone. present study resolves previously conflicting skeleton provides firm empirical basis...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVibrational Analysis of Nucleic Acids. 2. Ab Initio Calculation the Molecular Force Field and Normal Modes Dimethyl PhosphateYifu Guan, Godwin S.-C. Choy, Rainer Glaser, George J. Thomas Jr.Cite this: Phys. Chem. 1995, 99, 31, 12054–12062Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/j100031a039https://doi.org/10.1021/j100031a039research-articleACS...
An efficient and stereocontrolled synthetic strategy towards the synthesis of montanine-like alkaloids was developed. Our results suggest that structure elucidation for natural montabuphine needs further elaboration.
Tuberculosis (TB) is a highly contagious disease mainly caused by Mycobacterium tuberculosis H37 RV . Antitubercular (anti-TB) bioassay-guided isolation of the CHCl3 extract leaves and stems medicinal plant Ardisia gigantifolia led to two anti-TB 5-alkylresorcinols, 5-(8Z-heptadecenyl) resorcinol (1) 5-(8Z-pentadecenyl) (2). We further synthesized 15 derivatives based on these natural products. These compounds (natural synthetic) were evaluated for their activity against Resorcinols 1 2...
Raman and ir spectra are reported for diethyl phosphate [(CH3CH2O)2PO-2] isotopomers incorporating carbon-13 at methylene group sites [(CH133CH2O)2PO-2] deuterium substituents on methyl carbons [(CH3CD2O)2PO-2, (CD3CH2O)2PO-2 (CD3CD2O)2PO-2]. The vibrational analyzed to develop a consistent set of assignments the C-C-O-P(O-2)-O-C-C network, which serves as model nucleic acid phosphodiester backbone. present study resolves previously conflicting skeleton provides firm empirical basis...
Studies have implied the positive association of JAK2/STAT3 signaling with onset and severity acute pancreatitis (AP). However, definitive functional study in pathogenesis vivo is missing its potential as a therapeutic target underlying mechanisms remain to be determined.The aim this was explore role hyperlipidemia-intensified caerulin-induced AP target.Using rat model, we showed that activated pancreas systemic inflammation increased during AP. Pharmacological suppression JAK2 by inhibitor...