A5064820013- Natural product bioactivities and synthesis
- Aquaculture Nutrition and Growth
- Invertebrate Immune Response Mechanisms
- Traditional Chinese Medicine Analysis
- Advanced Glycation End Products research
- Aquaculture disease management and microbiota
- Crustacean biology and ecology
- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- Phytochemistry and Biological Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytoestrogen effects and research
- Pain Mechanisms and Treatments
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Liver Disease Diagnosis and Treatment
- Dermatology and Skin Diseases
- Immune cells in cancer
- Heat shock proteins research
- Flavonoids in Medical Research
- Genetic diversity and population structure
- Physiological and biochemical adaptations
- Ginseng Biological Effects and Applications
- Chronic Kidney Disease and Diabetes
Chongqing Medical University
2009-2025
Renji Hospital
2018-2025
Shanghai Jiao Tong University
2019-2025
Children's Hospital of Chongqing Medical University
2025
Guangdong Pharmaceutical University
2018-2024
Maternal and Child Health Hospital of Sichuan Province
2024
Sichuan University
2020-2024
Chongqing University
2007-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Guangxi University
2024
The study of pathophysiological mechanisms in human liver disease has been constrained by the inability to expand primary hepatocytes vitro while maintaining proliferative capacity and metabolic function. We others have previously shown that mouse mature can be converted progenitor-like cells with defined chemical factors. Here we describe a protocol achieving efficient conversion into (HepLPCs) through delivery developmentally relevant cues, including NAD + -dependent deacetylase SIRT1...
Abstract Deubiquitinating enzymes can prevent the destruction of protein substrates prior to proteasomal degradation. The ubiquitin-specific protease 2a (USP2a) deubiquitinates antiapoptotic proteins Fatty Acid Synthase and Mdm2. Here, we show that when USP2a is overexpressed in nontransformed cells, it exhibits oncogenic behavior both vitro vivo prevents apoptosis induced by chemotherapeutic agents. Notably, silencing several human cancer cell lines results apoptosis. Gene set enrichment...
Abstract A rapid and simple method has been developed for the screening identification of natural antioxidants Flos Lonicerae Japonicae (FLJ), derived from flower buds Lonicera japonica . The hypothesis is that upon reaction with 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), peak areas (PAs) compounds potential antioxidant effects in HPLC chromatograms will be significantly reduced or disappeared, identity confirmation could achieved by HPLC‐DAD‐TOF/MS hyphenated technique. Using proposed approach,...
Abstract The development of nanomedicines provides new opportunities for the treatment atherosclerosis (AS) due to their great advantages such as improved drug solubility, enhanced bioavailability and reduced side effects. Despite these advantages, are still facing some challenges. problems remain in short circulation life, lack specific targeting poor release controllability. In order overcome shortages conventional nanomedicines, combination biomimetic strategy with smart nanoagents has...
N6-methyladenosine (m6A) RNA modification is a fundamental determinant of mRNA metabolism in eukaryotic cells and involved numerous physiological pathological processes. However, the specific role m6A sepsis-induced acute respiratory distress syndrome(ARDS) remains unknown. Here, we show that levels were significantly decreased septic lungs METTL3 was main regulator absence modification. Pulmonary endothelial barrier damage critical process pathogenesis lung injury during sepsis. regulated...
Diabetic cognitive impairment (DCI) is a serious neurodegenerative disorder caused by diabetes, with chronic inflammation being crucial factor in its pathogenesis. Pterostilbene well-known natural stilbene derivative that has excellent anti-inflammatory activity, suggesting potential medicinal advantages for treating DCI. Therefore, this study to explore the beneficial effects of pterostilbene improving dysfunction DCI mice. A diabetic model was induced high-fat diet plus streptozotocin (40...
Intimal hyperplasia caused by vascular injury is an important pathological process of many diseases, especially occlusive disease. In recent years, Nano-drug delivery system has attracted a wide attention as novel treatment strategy, but there are still some challenges such high clearance rate and insufficient targeting.In this study, we report biomimetic ROS-responsive MM@PCM/RAP nanoparticle coated with macrophage membrane. The membrane the innate "homing" capacity can superiorly regulate...
Abstract A method, HPLC coupled with diode‐array and evaporative light scattering detectors (HPLC‐DAD‐ELSD), was newly developed to evaluate the quality of Flos Lonicerae (FL) Japonicae (FLJ), through a simultaneous determination multiple types bioactive components. By employing DAD, detection wavelengths were set at 240 nm for iridoids, 330 phenolic acids, 360 flavonoids, respectively. While ELSD, connected in series after applied saponins. This assay fully validated respect precision,...
Seedpod, the nonedible portion of lotus (Nelumbo nucifera Gaertn.), was reported to be rich in polyphenols. The objective this study investigate major bioactive polyphenols seedpods. total polyphenol content (TPC) from ethanol extract seedpod (PELS) found 34.23 μg gallic acid equivalents (GAE)/mg extract. Four polyphenolic compounds were identified PELS, comprised one flavan-3-ol (catechin) and three flavonoids (kaemferol, quercetin hyperoside). In vitro antioxidant antiproliferative...
We assessed the Th17 (T-helper cell)/Treg (Regulatory T cell) imbalance in sepsis patients with multiple organ dysfunction syndrome (MODS) and clinical benefits of continuous high-volume hemofiltration (HVHF).48 patients, including 22 MODS (MODS group, n = 22) 26 without (non-MODS 26), 20 healthy volunteer controls were enrolled. The group randomly divided into blood purification (CBP) (n 11) receiving conventional comprehensive treatment plus non-CBP only. At day 28, all 48 survival 36)...
Background and Purpose— Cerebral ischemic stroke elicits profound responses of CD4 + T cells, which in turn significantly affect the brain injury. ACC1 (acetyl coenzyme A carboxylase 1) is a key enzyme that has been recently found to propagate cell–associated inflammation by mediating de novo fatty acid synthesis; however, its role context remains unknown. Methods— Focal cerebral ischemia was induced transient middle artery occlusion for 60 minutes mice. Seahorse XF glycolysis assay targeted...
The rostral ventromedial medulla (RVM) exerts bidirectional descending modulation of pain attributable to the activity electrophysiologically identified pronociceptive ON and antinociceptive OFF neurons. Here, we report that GABAergic neurons specifically express G protein–coupled estrogen receptor (GPER). GPER+ exhibited characteristic ON-like responses upon peripheral nociceptive stimulation. Optogenetic activation facilitated, but their ablation abrogated, pain. Furthermore, GPER caused...
Summary The two most commonly used airway management techniques during general anaesthesia are supraglottic devices and tracheal tubes. In older patients undergoing elective non‐cardiothoracic surgery under with positive pressure ventilation, we hypothesised that a composite measure of in‐hospital postoperative pulmonary complications would be less frequent when device was compared tube. We studied aged ≥ 70 years in 17 clinical centres. Patients were allocated randomly to or Between August...
Abstract Background Hepatocellular carcinoma (HCC), the most common form of liver cancer, presents a challenging malignancy with scarce treatment options. Liver progenitor cells (LPCs) play pivotal role in both regeneration and progression yet specific functions LPCs from different origins cancer remain to be fully elucidated. Methods We explored progenitor-like derived human hepatocytes (HepLPCs) on proliferation HCC vitro vivo. The mitochondrial function was assessed through electron...