A5045938376- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- Lymphoma Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Graphene research and applications
- Mass Spectrometry Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Synthesis and Biological Evaluation
- Photoacoustic and Ultrasonic Imaging
- Chemical Reactions and Isotopes
University of Wisconsin–Madison
2014-2021
Shenzhen University
2019
National Cancer Institute
2018
National Institutes of Health
2018
Wisconsin Institutes for Discovery
2014
Personalized treatment plans for cancer therapy have been at the forefront of oncology research many years. With advent novel nanoplatforms, this goal is closer to realization today than ever before. Inorganic nanoparticles hold immense potential in field nano-oncology, but considerable toxicity concerns that limited their translation date. In review, an overview emerging biologically safe inorganic nanoplatforms provided, along with considerations challenges need be overcome theranostics...
Pembrolizumab is a humanized monoclonal antibody targeting programmed cell death protein 1 (PD-1) found on T and pro-B cells. prevents PD-1 ligation by both PD-L1 PD-L2, preventing the immune dysregulation that otherwise occurs when T-cells encounter cells expressing these ligands. Clinically, blockade elicits potent antitumor responses, antibodies blocking ligation, including pembrolizumab, have recently received Food Drug Administration approval for treatment of advanced melanoma, renal...
Abstract Acute kidney injury (AKI) is frequently associated with oxidative stress and causes high mortality annually in clinics. Nanotechnology‐mediated antioxidative therapy emerging as a novel strategy for the treatment of AKI. Herein, biomedical use endogenous biopolymer melanin theranostic natural antioxidant defense nanoplatform AKI reported. In this study, ultrasmall Mn 2+ ‐chelated (MMP) nanoparticles are easily prepared via simple coordination self‐assembly strategy, further...
Actively targeted theranostic nanomedicine may be the key for future personalized cancer management. Although numerous types of nanoparticles have been developed in past decade treatment, challenges still exist engineering biocompatible with highly specific vivo tumor targeting capabilities. Here, we report design, synthesis, surface engineering, and active vasculature a new category nanoparticle Water-soluble photothermally sensitive copper sulfide were encapsulated mesoporous silica...
Although various types of imaging agents have been developed for photoacoustic (PA) imaging, relatively few exhibit high selectivity/sensitivity to the tumor microenvironment on-demand PA and therapy. Herein, molybdenum-based polyoxometalate (POM) clusters with highest oxidation state Mo(VI) (denoted as Ox-POM) were designed novel redox-activated imaging-guided photothermal Capable escaping from recognition capture by liver spleen, these renal clearable ultrasmall size (hydrodynamic size:...
Although chelator‐based radiolabeling techniques have been used for decades, concerns about the complexity of coordination chemistry, possible altering pharmacokinetics carriers, and potential detachment radioisotopes during imaging driven need developing a simple yet better technique future radiolabeling. Here, emerging concept intrinsically radiolabeled nanoparticles, which could be synthesized using methods such as hot‐plus‐cold precursors, specific trapping, cation exchange, proton beam...
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is expressed on the surface of activated T cells and some tumor cells, target clinically approved monoclonal antibody ipilimumab. In this study, we investigate specific binding radiolabeled ipilimumab to CTLA-4 by human non-small cell lung cancer in vivo using positron emission tomography (PET). Ipilimumab was with 64Cu (t1/2 = 12.7 h) through use chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) formulate...
Oxidative stress is one of the important mechanisms in cerebral ischemia/reperfusion (I/R) injury. Antioxidants with high brain accumulation are highly desired to help prevent I/R Herein, intrathecal injection polyoxometalate (POM) nanoclusters as nano-antioxidants preferential uptake were applied for neuronal protection Using powerful positron emission tomography imaging, was non-invasively and real-timely monitored. Our results demonstrated that POM rapidly reached ischemic penumbra after...
Abstract Macrocyclic chelators have been widely employed in the realm of nanoparticle‐based positron emission tomography (PET) imaging, whereas its accuracy remains questionable. Here, we found that 64 Cu can be intrinsically labeled onto nanographene based on interactions between and π electrons graphene without need chelator conjugation, providing a promising alternative radiolabeling approach maintains native vivo pharmacokinetics nanoparticles. Due to abundant bonds, reduced oxide (RGO)...
Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve solubility inorganic nanoparticles, prevent their aggregation and prolong in vivo blood circulation half-life. Herein, we developed double-PEGylated biocompatible reduced graphene oxide nanosheets anchored with iron nanoparticles (RGO–IONP–1stPEG–2ndPEG). The nanoconjugates exhibited a prolonged half-life (∼27.7 h) remarkable tumor accumulation (>11 %ID g−1) via an enhanced permeability...
Overexpression of CD146 has been correlated with aggressiveness, recurrence rate, and poor overall survival in hepatocellular carcinoma (HCC) patients.In this study, we set out to develop a CD146-targeting probe for high-contrast noninvasive vivo positron emission tomography (PET) near-infrared fluorescence (NIRF) imaging HCCs.YY146, an anti-CD146 monoclonal antibody, was employed as targeting molecule which conjugated the zwitterionic dye ZW800-1 chelator deferoxamine (Df).This enabled...
Effective therapy for protecting dying neurons against cerebral ischemia-reperfusion injury (IRI) represents a substantial challenge in the treatment of ischemic strokes. Oxidative stress coupled with excessive inflammation is main culprit brain IRI that results neuronal damage and disability. Specifically, complement component 5a (C5a) exacerbates vicious cycle between oxidative inflammatory responses. Herein, we propose framework nucleic acid (FNA) conjugated anti-C5a aptamers (aC5a) can...
Theranostic nanoparticles hold the potential to greatly improve cancer management by providing personalized medicine. Although many theranostic nanoconstructs have been successful in preclinical studies, clinical translation is still hampered their limited targeting capability and lack of therapeutic efficacy. We report use novel ultrasmall porous silica (UPSN) with enhanced vivo pharmacokinetics such as high target tissue accumulation (12% ID/g tumor) evasion from reticuloendothelial system...
Manganese oxide nanoparticles (Mn3O4 NPs) have attracted a great deal of attention in the field biomedical imaging because their ability to create an enhanced signal MRI as novel potent T1 contrast agents. In this study, we present tumor vasculature-targeted mice using Mn3O4 NPs through conjugation anti-CD105 antibody TRC105 and radionuclide copper-64 (64Cu, t1/2: 12.7 h). The conjugated NPs, 64Cu-NOTA-Mn3O4@PEG-TRC105, exhibited sufficient stability vitro vivo. Serial positron emission...
For melanoma resistant to molecularly targeted therapy and immunotherapy, new treatment strategies are urgently needed. A theranostic pair may thus be of importance, where the diagnostic probe facilitates patient stratification therapeutic companion treats selected cases. this purpose, flow cytometry is used assess CD146 level in cells. Based on YY146, a CD146-specific monoclonal antibody, an imaging