A5100344752- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced biosensing and bioanalysis techniques
- Animal Genetics and Reproduction
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Reproductive Biology and Fertility
- Dental Implant Techniques and Outcomes
- Gut microbiota and health
- Probiotics and Fermented Foods
- Tuberculosis Research and Epidemiology
- Meat and Animal Product Quality
- Bone Metabolism and Diseases
- Protein Hydrolysis and Bioactive Peptides
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Fatty Acid Research and Health
- Viral gastroenteritis research and epidemiology
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
Guangxi University
2015-2025
Stomatology Hospital
2019-2025
Sun Yat-sen University
2019-2025
Northeast Normal University
2022-2025
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Hospital of Stomatology, Sun Yat-sen University
2019-2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2015-2024
Jiangsu Cancer Hospital
2019-2024
Abstract Activation of hepatic stellate cells (HSCs) has been demonstrated to play a pivotal role in the process liver fibrogenesis. In this study, we observed decrease expression KIF18A fibrotic tissues compared healthy tissues, which exhibited negative correlation with activation HSCs. To elucidate molecular mechanisms underlying involvement KIF18A, performed vitro proliferation experiments and established CCl4-induced fibrosis model. Our results revealed that knockdown enhanced HSCs...
Abstract Biological hydroxyapatite (BHA) has been widely used in alveolar bone augmentation, while unfavorable outcomes can still be encountered. Among several reasons, we noticed a chaotic granule size application issue. The principle behind the choice of proper mainly lies fitness defect shape and size. However, shown to elicit significant biological effects, with underlying mechanisms unknown. BHA granules five different sizes were first prepared characterized investigate their effects....
Abstract: The high aqueous solubility, poor permeability, and absorption of berberine (BBR) result in its low plasma level after oral administration, which greatly limits clinical application. BBR solid lipid nanoparticles (SLNs) were prepared to achieve improved bioavailability prolonged effect. Developed SLNs showed homogeneous spherical shapes, small size (76.8 nm), zeta potential (7.87 mV), encapsulation efficiency (58%), drug loading (4.2%). power X-ray diffraction combined with 1 H...
Both Ganoderma lucidum (GL) and G. sinense (GS) are used as Lingzhi in China. Their functions assumed to mainly derive from triterpenes polysaccharides; however, the two species have very different profiles, if this was case, then bioactivity of these should differ. Instead, could polysaccharides be similar, contributing shared therapeutic basis? In study, main polysaccharide fractions batches GL GS were systematically compared by a series chemical biological experiments. The results showed...
Abstract Buffalo is an important livestock species. Here, we present a comprehensive metagenomic survey of the microbial communities along buffalo digestive tract. We analysed 695 samples covering eight different sites in three compartments (four-chambered stomach, intestine, and rectum). mapped ~85% raw sequence reads to 4,960 strain-level metagenome-assembled genomes (MAGs) 3,255 species-level MAGs, 90% which appear correspond new In addition, annotated over 5.8 million nonredundant...
Berberine (BBR) shows very low plasma levels after oral administration due to its poor absorption by the gastrointestinal tract. We have previously demonstrated that BBR showed increased and enhanced antidiabetic effects in db/db mice being entrapped into solid lipid nanoparticles (SLNs). However, whether BBR-loaded SLNs (BBR-SLNs) also beneficial on hepatosteatosis is not clear. investigated of BBR-SLNs metabolism liver using histological staining reverse transcription polymerase chain...
Domesticated buffaloes have been integral to rice-paddy agro-ecosystems for millennia, yet relatively little is known about the buffalo genomics. Here, we sequenced and assembled reference genomes both swamp river re-sequenced 230 individuals (132 98 buffaloes) sampled from across Asia Europe. Beyond many actionable insights that our study revealed domestication, basic physiology breeding of buffalo, made striking discovery divergent domestication traits between can be explained with recent...
Abstract Background and Objective Peri‐implantitis is a biofilm‐mediated infectious disease that results in progressive loss of implant‐supporting bone. As compared to its analogue periodontitis, peri‐implantitis generally known be more aggressive, with comparatively rapid progression less predictable treatment outcomes, especially when advanced. An understanding molecular mechanisms underpinning the similarities differences between periodontitis essential develop novel management...
Apigenin (API), a natural plant flavone, is abundantly found in common fruits and vegetables. As bioactive flavonoid, API exhibits several activities including antiproliferation anti-inflammation. A recent study showed that could retard osteoporosis progress, indicating its role the skeletal system. However, detailed function mechanism remain obscure. In present study, was to promote osteogenic differentiation of mesenchymal stem cells (MSCs). And further investigation enhance expression...
Herein, we reported an N-heterocyclic carbene (NHC) and photo-co-catalyzed alkylacylation of olefins in the presence versatile synthon diazo ester, providing a new idea for transient radical generation with only byproduct being N2. Particularly, this process employs traditional precursor esters as source, which is first case NHC catalysis. Compared to previous pathway that produces radicals large discard fragments, merged channel possesses great atom economy.
Goat is an important livestock worldwide, which plays indispensable role in human life by providing meat, milk, fiber, and pelts. Despite recent significant advances microbiome studies, a comprehensive survey on the goat microbiomes covering gastrointestinal tract (GIT) sites, developmental stages, feeding styles, geographical factors still unavailable. Here, we surveyed its multi-kingdom microbial communities using 497 samples from ten sites along GIT.We reconstructed catalog (GMMC)...
Dendrobium officinale extract shows potent anti-fatigue effects; however, the active substance responsible for these effects remains undetermined. A glucomannan with a huge molecular size of 730 kDa, called DOP, was identified as unique authentication marker this expensive herb. DOP exhibited immunomodulating on macrophages and lymphocytes in our previous study. Clinical reports also showed that people fatigue syndrome have disturbed immune system. Because is dominant component D....
To evaluate the effect of six scan patterns on accuracy and speed digital impressions with two different intraoral scanners for complete-arch implant rehabilitation.A master model containing parallelly placed analogs was fabricated, bodies were connected to analogs. Reference obtained a laboratory scanner. Test scans by scanning using 3Shape TRIOS 3 Carestream CS 3600 scanners. Scanning time recorded. Trueness precision assessed an inspection software. Two-way analysis variance (ANOVA)...
Systemic inflammation plays an important role in the pathophysiology and progression of aneurysmal subarachnoid hemorrhage (aSAH). In this study, we aimed to investigate association between a new biomarker, inflammatory burden index (IBI) prognosis as well in-hospital complications aSAH patients.We analyzed data from patients with January 2019 September 2022 who were included LongTEAM (Long-term Prognosis Emergency Aneurysmal Subarachnoid Hemorrhage) registry study. The IBI was formulated...
Background: Brain arteriovenous malformations (AVMs) account for 25% of hemorrhagic strokes in young adults. Although embolization has been widely performed as a stand-alone procedure to cure brain AVM, it is undermined whether patients benefit from this treatment. This study aimed compare the long-term outcome stroke or death with either conservative management AVM. Methods: The population was derived nationwide multicenter prospective collaboration registry (the *BLINDED* registry) between...
The incidence of thyroid carcinoma has obviously been rising throughout the world during past ten years.
Rotavirus is the leading cause of severe dehydrating diarrhea in young children and inner capsid protein VP6 a potential vaccine candidate that can induce cross-protective immune responses against different strains. The use ferritin nanoparticles as scaffold antigen improve immunogenicity subunit vaccines provide broader protection. We here present non-live self-assemble recombinant rotavirus VP6-ferritin (rVP6-ferritin) nanoparticle vaccine.The rVP6-ferritin were expressed E. coli...
Consumers have shown more and interest in high-quality healthy dairy products buffalo milk is commercially viable than other milks producing superior due to its higher contents of fat, crude protein, total solids. Metabolomics one the most powerful strategies molecular mechanism research however, little study has been focused on metabolites different species. Therefore, aim this was explore underlying fatty synthesis candidate biomarkers by analyzing metabolomic profiles. Milk three groups...
More than 10 years have passed since the two best-known clinical trials of ruptured aneurysms (International Subarachnoid Aneurysm Trial [ISAT] and Barrow Ruptured [BRAT]) indicated that endovascular coiling (EC) was superior to surgical clipping (SC). However, in recent years, development techniques has greatly improved; thus, it is necessary reanalyze impact differences treatment modalities on prognosis patients with aneurysmal subarachnoid hemorrhage (aSAH).
Despite the diverse roles of tripartite motif (Trim)-containing proteins in regulation autophagy, innate immune response, and cell differentiation, their skeletal diseases are largely unknown. We recently demonstrated that Trim21 plays a crucial role regulating osteoblast (OB) differentiation osteosarcoma. However, how contributes to degenerative disorders, including osteoporosis, remains First, human mouse bone specimens were evaluated, results showed expression was significantly elevated...