A5080235402- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Telomeres, Telomerase, and Senescence
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Cell death mechanisms and regulation
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Endoplasmic Reticulum Stress and Disease
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurosurgical Procedures and Complications
- Nerve injury and regeneration
- Plant biochemistry and biosynthesis
- Vector-borne infectious diseases
- Genetics, Aging, and Longevity in Model Organisms
- Bone Metabolism and Diseases
- Ubiquitin and proteasome pathways
Southern Medical University
2016-2024
Entry Exit Inspection and Quarantine Bureau
2014-2019
Chinese University of Hong Kong
2013-2018
Prince of Wales Hospital
2014-2018
Guangzhou Institute of Advanced Technology
2013-2017
Chinese Academy of Sciences
2013-2017
Second Affiliated Hospital of Zhejiang University
2010-2015
Zhejiang University
2012-2015
Zhejiang Provincial People's Hospital
2013
National Institutes of Health
2002-2009
The transcription factor NF-κB is expressed in neurons wherein it activated response to a variety of stress- and injury-related stimuli including exposure cytokines such as tumor necrosis factor-α (TNFα), excitotoxic oxidative insults. may play role the anti-death actions TNFα cultured hippocampal exposed metabolic We now report that pretreatment cell cultures with agents activate (TNFα C2-ceramide) confers resistance apoptosis induced by insults FeSO4 amyloid β-peptide (Aβ25–35)....
Circular RNAs are a class of regulatory RNA transcripts, which ubiquitously expressed in eukaryotes. In the current study, we evaluate function novel circRNA derived from β-catenin gene locus, circβ-catenin. Circβ-catenin is predominantly localized cytoplasm and displays resistance to RNase-R treatment. We find that circβ-catenin highly liver cancer tissues when compared adjacent normal tissues. Silencing significantly suppresses malignant phenotypes vitro vivo, knockdown this reduces...
AbstractOsteogenic differentiation of mesenchymal stem cells (MSCs) is a complex process, which regulated by various factors including microRNAs. Our preliminary data showed that the expression endogenous miR-20a was increased during course osteogenic differentiation. Simultaneously, osteoblast markers and regulators BMP2, BMP4, Runx2, Osx, OCN OPN also elevated whereas adipocyte PPARγ antagonist, Bambi Crim1, were downregulated, thereby suggesting plays an important role in regulating To...
Bone homeostasis is tightly orchestrated and maintained by the balance between osteoblasts osteoclasts. Recent studies have greatly expanded our understanding of molecular mechanisms cellular differentiation. However, functional roles non-coding RNAs particularly lncRNAs in remodeling bone architecture remain elusive. In study, lncRNA H19 was found to be upregulated during osteogenesis hMSCs. Stable expression significantly accelerated vivo vitro osteoblast Meanwhile, using bioinformatic...
Abstract We report increased modification of proteins by 4‐hydroxynoneal (HNE), a product membrane lipid peroxidation, in the lumbar spinal cord sporadic amyotrophic lateral sclerosis (ALS) patients versus that neurologically normal controls. By immunohistochemistry, HNE‐protein was detected ventral horn motor neurons, and immunoprecipitation analysis revealed one modified HNE astrocytic glutamate transporter EAAT2. Given function can be severely compromised as previously demonstrated for...
Calcium influx through NMDA receptors and voltage-dependent calcium channels (VDCC) mediates an array of physiological processes in neurons may also contribute to neuronal degeneration death neurodegenerative conditions such as stroke severe epileptic seizures. Gelsolin is a Ca2+-activated actin-severing protein that expressed neurons, wherein it mediate motility responses Ca2+ influx. Primary hippocampal cultured from mice lacking gelsolin exhibited decreased actin filament depolymerization...
Telomerase is a protein-RNA enzyme complex that adds six-base DNA sequence (TTAGGG) to the ends of chromosomes and thereby prevents their shortening. Reduced telomerase activity associated with cell differentiation accelerated cellular senescence, whereas increased transformation immortalization. Because many types cancer have been reduced apoptosis, senescence we tested hypothesis mechanistically involved in regulation apoptosis. Levels cultured pheochromocytoma cells decreased prior death...
The bcl-2 protooncogene product possesses antiapoptotic properties in neuronal and nonneuronal cells. Recent data suggest that Bcl-2's potency as a survival factor hinges on its ability to suppress oxidative stress, but neither the subcellular site(s) nor mechanism of action is known. In this report electron paramagnetic resonance (EPR) spectroscopy analyses were used investigate local effects Bcl-2 membrane lipid peroxidation. Using hydrogen peroxide (H2O2) amyloid beta-peptide (A beta)...
// Wei-ming Fu 2, * , Ying-fei Lu 3, Bao-guang Hu 4 Wei-cheng Liang 5 Xiao Zhu 6 Hai-di Yang 7 Gang Li 8 Jin-fang Zhang 1, 1 School of Medicine, South China University Technology, Guangzhou 511458, P.R. 2 Institute Advanced Chinese Academy Sciences, 3 Department Orthopaedics and Traumatology, The Hong Kong, Prince Wales Hospital, Shatin, Gastrointestinal Surgery, Affiliated Hospital Binzhou Medical University, Binzhou, Shandong, Biomedical Faculty P. R. Guangdong Province Key Laboratory...
Both Rosa roxburghii and R. sterilis, belonging to the Rosaceae, are endemic species in Guizhou Province, China. The fruits of these two mixed-used as functional food region. Aiming elucidate phytochemical characteristics sterilis fruits, essential oils constituents a methanol extract have been analyzed compared by GC-MS UFLC/Q-TOF-MS, respectively. As result, total 135 volatile compounds were identified 91 components different between fruits; 59 extracts including 13 organic acids, 12...
Long noncoding RNAs (lncRNAs), which serve as important and powerful regulators of various biological activities, have gained widespread attention in recent years. Emerging evidence has shown that some lncRNAs play regulatory roles osteoblast differentiation mesenchymal stem cells (MSCs), suggesting a potential therapeutic strategy for bone fracture. As recently identified lncRNA, linc-ROR was reported to mediate the reprogramming ability differentiated into induced pluripotent (iPSCs) human...
The catalytic subunit of telomerase (TERT) is a specialized reverse transcriptase that has been associated with cell immortalization and cancer. It was reported recently TERT expressed in neurons throughout the brain embryonic early postnatal development, but absent from adult brain. We now report suppression levels function mouse hippocampal culture using antisense technology inhibitor 3' -azido-2' -dideoxythymidine significantly increases their vulnerability to death induced by amyloid...
Tendon injures are common orthopedic conditions, but tendon development and the pathogenesis of injures, such as tendinopathy, remain largely unknown have limited clinical therapy. Studies on tenogenic differentiation at molecular level may help in developing novel therapeutic strategies. As regulators, long noncoding RNAs (lncRNAs) been found to widespread biological functions, emerging evidence demonstrates that lncRNAs play important regulatory roles cell tissue regeneration. In this...