A5100406256- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Nanoparticle-Based Drug Delivery
- Cancer-related Molecular Pathways
- Chalcogenide Semiconductor Thin Films
- Quantum Dots Synthesis And Properties
- Food composition and properties
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Perovskite Materials and Applications
- Lung Cancer Treatments and Mutations
- Optical Wireless Communication Technologies
- Carbon and Quantum Dots Applications
- Tuberculosis Research and Epidemiology
- Traditional Chinese Medicine Analysis
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- Mycobacterium research and diagnosis
Fudan University Shanghai Cancer Center
2014-2025
Nanjing University of Chinese Medicine
2022-2025
Shandong Food Fermentation Industry Research and Design Institute
2020-2024
Shandong Academy of Sciences
2020-2024
Qilu University of Technology
2020-2024
Fudan University
2014-2024
Collaborative Innovation Center of Chemistry for Energy Materials
2024
Center for Excellence in Molecular Plant Sciences
2024
Shanghai Medical College of Fudan University
2011-2024
Chinese Academy of Sciences
2024
The biological significance of a known normal and cancer stem cell marker CD133 remains elusive. We now demonstrate that the phosphorylation tyrosine-828 residue in C-terminal cytoplasmic domain mediates direct interaction between phosphoinositide 3-kinase (PI3K) 85 kDa regulatory subunit (p85), resulting preferential activation PI3K/protein kinase B (Akt) pathway glioma (GSC) relative to matched nonstem cell. knockdown potently inhibits activity PI3K/Akt with an accompanying reduction...
Abstract Background The tumor suppressor FBW7 is the substrate recognition component of SCF E3-ubiquitin ligase complex that mediates proteolytic degradation various oncogenic proteins. However, role in ovarian cancer progression remains inadequately understood. Methods IP-MASS, co-IP, immunohistochemistry, and western blotting were used to identify potential cancer. biological effects investigated using vitro vivo models. LC/MS was detect m 6 A levels tissues. MeRIP-Seq RNA-Seq assess...
Neat1 is widely expressed in many tissues and cells exerts pro-proliferation effects on cancer cells. However, little known about the function of myogenesis. Here we characterized roles muscle cell formation regeneration. Gain- or loss-of-function studies C2C12 demonstrated that accelerates myoblast proliferation but suppresses differentiation fusion. Further, knockdown vivo increased cross-sectional area fibers impaired Mechanically, physically interacted with Ezh2 mainly through core...
p53 inactivation is highly associated with tumorigenesis and drug resistance. Here, we identify a long noncoding RNA, the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP), as an inhibitor p53. RMRP overexpressed unfavorable prognosis in colorectal cancer. Ectopic suppresses activity by promoting MDM2-induced ubiquitination degradation, while depletion activates pathway. also promotes cancer growth proliferation p53-dependent fashion vitro vivo. This anti-p53 action...
Viperin is a type-I and -II interferon-inducible intracytoplasmic protein that mediates antiviral activity against several viruses. A previous study has reported viperin could limit hepatitis C virus (HCV) replication in vitro . However, the underlying mechanism remains elusive. In present study, we found overexpression of inhibit HCV dose-dependent manner both replicon HCVcc systems. Furthermore, through co-immunoprecipitation laser confocal microscopic analysis, was to interact with host...
Imaging-guided site-specific photothermal therapy (PTT) of glioma and other tumors in central nervous system presents a great challenge for the current nanomaterial design. Herein, an situ solid-state transformation method was developed preparation multicolor highly crystalline carbon nanodots (HCCDs). The synthesis yields 6-8 nm-sized HCCDs containing nanocore hydrophilic surface, which therefore simultaneously provide strong photoacoustic performances as well tunable fluorescence emission....
The aim of this study was to determine the function NEAT1/miR-23a-3p/SMC1A axis in cell proliferation and apoptosis acute myeloid leukemia (AML). Microarray analysis used screen differentially expressed lncRNAs/miRNAs/mRNAs primary AML cells. expression nuclear paraspeckle assembly transcript 1 (NEAT1), miR-23a-3p, structural maintenance chromosome alpha (SMC1A) cells THP-1 were measured by quantitative real-time polymerase chain reaction (qRT-PCR). A Cell Counting Kit-8 (CCK-8) assay...
Abstract It was believed that the Se‐rich synthesis condition can suppress formation of deep‐level donor defect V Se (selenium vacancy) in Sb 2 3 and is thus critical for fabricating high‐efficiency solar cells. However, here it shown by first‐principles calculations density increases unexpectedly to 10 16 cm −3 when chemical potential increases, so promotes rather than suppresses . Therefore, high thermodynamically inevitable, no matter under Se‐poor or conditions. This abnormal behavior be...
Abstract Depletion of arginine by recombinant human arginase (rhArg) has proven to be an effective cancer therapeutic approach for a variety malignant tumors. Triple-negative breast cancers (TNBCs) lack specific targets, resulting in poor prognosis and limited efficacy. To explore new approaches TNBC we studied the cytotoxicity rhArg five cells. We found that could inhibit cell growth these Intriguingly, accumulation autophagosomes autophagic flux was observed rhArg-treated MDA-MB-231...
// Chen Lin 1, * , Shanshan Wang Weiwei Xie 1 Rongliang Zheng 2 Yu Gan 3 Jianhua Chang Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China Nuclear Medicine, Sun Yat-Sen Guangzhou, 510000, State Key Laboratory Oncogenes and Related Genes, Institute, Renji Hospital, Jiao Tong School These authors contributed equally to this work Correspondence to: Chang, email: changjianhua@163.com Gan, ganyu@shSCI.org Keywords: apatinib, KIF5B-RET, invasion...
Background: The N6-methyladenosine (m 6 A) modification plays a critical role in cancer development. Little is known about the m A triple-negative breast (TNBC), most aggressive subtype of cancer. Thus, prognostic value RNA methylation TNBC deserves exploration. Methods: expression levels 13 regulators were compared between 98 tumor samples and normal tissue based on transcriptome profiles from Cancer Genome Atlas (TCGA). association patients' overall survival was assessed by Kaplan-Meier...
The management of multidrug-resistant tuberculosis (MDR-TB) remains challenging. Treatment outcome is influenced by multiple factors; the specific roles diabetes and glycemic control remain uncertain. This study aims to assess impact on drug exposure, investigate association between exposure treatment outcomes, identify clinically significant thresholds predictive outcome, among patients with diabetes.
Purpose: Metastatic non-small cell lung cancer (NSCLC) remains a global health threat, with patients facing inevitable disease progression despite standard-of-care therapy. Prior studies showed Platycodin D (PD)-induced cycle arrest and apoptosis in NSCLC via RNA regulatory network, yet elucidating PD's mechanisms is challenging the real world. Methods: Biological effects of PD on lines A549 PC-9 were assessed through vitro assays, encompassing apoptosis, proliferation, colony formation,...
Introduction: Hepatocellular carcinoma (HCC) has a high incidence rate and is often asymptomatic in its early stages. Combination therapies using immune checkpoint inhibitors (ICIs) have demonstrated survival benefits objective response rates, offering hope for conversion surgery patients with initially unresectable HCC. We aimed to investigate the oncological outcomes of compared those continuing systemic treatment alone who responded well ICIs-based therapy, as surgical associated surgery....
790 Background: Fexagratinib (former AZD4547), a selective and potent oral inhibitor of FGFR1-3, has shown promising efficacy safety in phase I trials among solid tumor pts with FGFR1-3 alterations, including mUC. This study (NCT05086666) aimed to assess Fexa previously treated Chinese mUC FGFR alterations. Methods: Pts harboring FGFR3 alterations (including activating mutations or fusion detected via NGS panel) who failed at least 1 prior therapy were platinum- ineligible, enrolled....
We recently reported that Ras-GTPase-activating protein-binding protein 1 (G3BP1) interacts with hepatitis C virus (HCV) nonstructural (NS)5B and the 5' end of HCV minus-strand RNA. In current study we confirmed these observations using immunoprecipitation RNA pulldown assays, suggesting G3BP1 might be an replication complex (RC) component. replicon cells, transfected multiple proteins. Using immunostaining confocal microscopy, demonstrate is colocalized RCs in cells. Small interfering...