A5103168948- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Head and Neck Cancer Studies
- Histone Deacetylase Inhibitors Research
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Animal Virus Infections Studies
- Pancreatic and Hepatic Oncology Research
- Oral health in cancer treatment
Shanghai Medical College of Fudan University
2020-2024
Fudan University Shanghai Cancer Center
2016-2024
Abstract Background The tumor suppressor FBW7 is the substrate recognition component of SCF E3-ubiquitin ligase complex that mediates proteolytic degradation various oncogenic proteins. However, role in ovarian cancer progression remains inadequately understood. Methods IP-MASS, co-IP, immunohistochemistry, and western blotting were used to identify potential cancer. biological effects investigated using vitro vivo models. LC/MS was detect m 6 A levels tissues. MeRIP-Seq RNA-Seq assess...
Circular RNAs (circRNAs) are a novel class of non-coding which play important roles in human diseases and tumor progression. However, the function circRNAs ovarian cancer remains to be uncovered. Here we found large amount that differentially expressed tissues compared with normal tissues. We further identified one circRNA derived from LPAR3 gene termed Circ0004390, was frequently upregulated The knockdown Circ0004390 can significantly reduce proliferation cells. demonstrated may promote...
Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed compare the predictive ability of yielding pathologic log odds positive lymph nodes (yp-LODDS) that yp-LNR for cancer-specific survival (CSS) III pre-RT.We analyzed pre-RT Surveillance, Epidemiology and End Results (SEER) database. Patients were classified into 4 groups, yp-LNR1 4, based on LNR cutoff...
Background . In general, younger age is associated with better survival in patients colon cancer. this study, we aim to analyze the impact of on cancer-specific (CSS) signet-ring cell carcinoma (SRCC) colon, a particularly aggressive type Methods Information SRCC no distant metastasis was extracted from US Surveillance, Epidemiology, and End Results (SEER) database. An X-tile plot used determine optimal cutoff at diagnosis. A total 776 were included data analysis. The program revealed an 35...
Abstract Background Poly (ADP-ribose) polymerase inhibitor (PARPi) resistance poses a significant challenge in ovarian carcinoma (OC). While the role of DOT1L cancer and chemoresistance is acknowledged, its specific PARPi remains unclear. This study aims to elucidate molecular mechanism OC patients. Methods analyzed expression PARPi-resistant cell lines compared sensitive ones correlated it with clinical outcomes Comprehensive vitro vivo functional experiments were conducted using cellular...
Background Ovarian clear cell carcinoma (OCCC) is a rare and chemo-resistant subtype of ovarian cancer. While immunotherapy has demonstrated effectiveness in some OCCC cases, the mechanisms for heterogeneous immunoreactivity potential combinatory strategies remain unclear. Methods Tumor samples from 13 patients with underwent single-cell mRNA-seq TCR-seq to generate 1 40 683 cells transcriptome, while additionally 31 formalin-fixed paraffin-embedded were used immunohistochemistry. Spatial...
Background We aim to compare the prognosis between patients with stage IIA and IIIA colon cancer. Methods analysed or cancer based on data from US Surveillance, Epidemiology, End Results ( SEER ) database. Survival were generated as Kaplan–Meier curves compared by log‐rank tests. A multivariate Cox proportional hazards model was used analyze risk factors. In total, 43 379 (38 784 4595 included analysis showed no significant difference P = 0.547). subgroup of number lymph nodes harvested LNH...
Aim: The purpose of this study was to analyze the incidence, clinical characteristics, prognostic factors and survival ovarian cancer patients with liver metastases upon initial diagnosis. Methods: Patients diagnosis between 2010 2016 were identified from Surveillance, Epidemiology, End Results (SEER) database. Univariate multivariate logistic regression performed identify predictors presence in newly diagnosed patients. Overall (OS) assessed using Kaplan-Meier method log-rank test. Cox...
<h3>Introduction/Background</h3> Lymph node metastasis (LNM), the dominated metastatic pattern in cervical cancer, is a profound prognostic factor and important treatment decision-making. Therefore, to unveil mechanism of this process explore new target for cancer can be great significance. <h3>Methodology</h3> We performed vivo genome-wide CRISPR/Cas9 knockout screening identify key regulators lymph metastasis. next investigated molecular DUSP4 deficiency promoting by reverse phase protein...
<h3>Introduction/Background</h3> Radioresistance is the leading cause of death in advanced cervical cancer (CC). Dysregulation RNA modification has recently emerged as a regulatory mechanism irradiation and drug resistance. We aimed to explore biological function clinical significance 5-methylcytosine (m5C) methyltransferase NSUN6 radiosensitivity. <h3>Methodology</h3> <h3>Results</h3> found higher abundance m5C resistant CC samples, essential m5C-regulated gene overexpression was clinically...