A5100680495- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Thyroid Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- CNS Lymphoma Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Breast Lesions and Carcinomas
- Viral Infections and Vectors
- Viral-associated cancers and disorders
- RNA Interference and Gene Delivery
- Viral Infections and Outbreaks Research
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Acute Lymphoblastic Leukemia research
- Cancer, Lipids, and Metabolism
- CRISPR and Genetic Engineering
Army Medical University
2025
Sichuan Academy of Agricultural Sciences
2025
Zhejiang University
2025
Dalian Medical University
2018-2024
Chongqing Medical University
2018-2024
Second Affiliated Hospital of Chongqing Medical University
2018-2024
China Rehabilitation Research Center
2024
Taian City Central Hospital
2012-2023
Shaanxi Normal University
2022-2023
Cleveland Clinic Florida
2021
Obesity-induced chronic inflammation is a key component in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Increased secretion proinflammatory cytokines by macrophages metabolic tissues promotes progression. In diet-induced obesity (DIO) mouse model, activation resident macrophages, or Kupffer cells (KCs), drives inflammatory responses, which recruits circulating development, ultimately contributes to impaired hepatic sensitivity. Hepatic express highest...
Current guidelines recommend breast magnetic resonance imaging (MRI) as an adjunct to mammography for cancer screening in female survivors treated with chest irradiation at a young age, beginning 8 10 years after treatment. Prospective data evaluating its efficacy are lacking. This study sought compare the sensitivity and specificity of MRI those women who received Hodgkin lymphoma (HL).We enrolled 148 HL age ≤ 35 were > beyond Yearly mammogram performed over 3-year period. Sensitivity two...
Purpose The optimal treatment for early-stage, lymphocyte-predominant Hodgkin's lymphoma (LPHL) is not well defined. Treatment has become less aggressive over time in an attempt to reduce iatrogenic complications, such as cardiac mortality and second cancers, but long-term efficacy unclear. We present the outcome of patients treated at a single institution. Patients Methods study population includes 113 with stage I or II LPHL between 1970 2005. Pathologic diagnosis all was confirmed using...
BACKGROUND Advanced uterine leiomyosarcoma (ULMS) is an incurable disease. A significant percentage of cases ULMS express estrogen and/or progesterone receptors (ER PR). To the authors' knowledge, role suppression in disease management not known. METHODS The authors performed a single‐arm phase 2 study aromatase inhibitor letrozole at dose 2.5 mg daily patients with unresectable ER PR expression confirmed by immunohistochemistry. Tumor assessments were baseline, 6 weeks, 12 and every 8 weeks...
The optimal therapy for primary mediastinal B-cell lymphoma is a subject of ongoing debate, with no accepted standard care. We performed retrospective analysis 63 patients in the modern era treated rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP), or without radiation. Median age was 37 years (range 20-82). Eighty percent had limited stage disease 71% were bulky. By age-adjusted International Prognostic Index (IPI), 15% low-risk, 52% low-intermediate, 27%...
We postulated that expression differences of autophagy-related genes are instrumental in stratifying the risk early relapse after surgery and evaluating prognosis patients with stages I-III colon cancer. Therefore, propensity score matching analysis was performed between group long-term survival from GSE39582 test series internal validation series. Using Cox regression model, a nine-autophagy-related signature (CAPN2, ATG16L2, TP63, SIRT1, RPS6KB1, PEX3, ATG5, UVRAG, NAF1) established to...
Colon cancer patients experiencing early relapse consistently exhibited poor survival. The aim of our study was to develop an mRNA signature that can help detect cases in stage I-III colon cancer. Public microarray datasets samples were extracted from the Gene Expression Omnibus database. Propensity score matching analysis performed between group and long-term survival GSE39582 discovery series (N = 386), 1 : matched. Global expression changes then analyzed paired groups identify...
Epigenetic regulators, when genomically altered, may become driver oncogenes that mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic stimulus, such as activation of the WNT/β-catenin pathway in melanoma. This study identifies previously unrecognized recurrent activating mutations G9a histone methyltransferase gene, well genomic copy gains approximately 26% human melanomas, which collectively drive tumor growth and an immunologically sterile microenvironment beyond...
Abstract Triple-negative breast cancer (TNBC) is a particularly aggressive and heterogeneous disease with few effective targeted therapies precision therapeutic options over long period. It generally considered that TNBC an estrogen-independent cancer, while new estrogen receptor, namely G protein-coupled receptor (GPER), demonstrated to mediate estrogenic actions in TNBC. Based on our transcriptomic analysis, expression of GPER was correlated clinicopathological variables survival 360...
The marginal zone lymphomas (MZLs) are a recently defined group of related diseases that probably arise from common cell origin, the B cell. Data on therapy for subtypes other than gastric mucosa-associated lymphoid tissue (MALT) lymphoma has been largely limited to retrospective case series. This prospective phase 2 study fludarabine and rituximab treatment enrolled 26 patients, 14 with nodal MZL, eight MALT four splenic MZL; 81% were receiving initial systemic therapy. Only 58% [95%...
Abstract BACKGROUND: The majority of patients with Hodgkin lymphoma (HL) achieve disease remission after primary therapy. To the best authors' knowledge, no consensus exists for postremission surveillance imaging. METHODS: Retrospectively analyzed were 192 adult classic HL in first remission. Events defined as recurrent or secondary malignancies. Primary outcome was positive predictive value (PPV) positron emission tomography/computed tomography (PET/CT) and CT scans event detection....
Purpose Ifosfamide-induced encephalopathy is a neurotoxic adverse effect of ifosfamide chemotherapy. The objective this study was to determine the incidence in patients with lymphoma and sarcoma receiving chemotherapy assess for potential risk factors that influence encephalopathy. Methods A retrospective performed at participating institutions. Enrollment began 1 July 2011 continued chronologically backwards until 100 were enrolled. Identification ifosfamide-induced events by reviewing...
Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening infectious disease caused by the SFTS virus (SFTSV). This study aimed to evaluate predictive power of C-reactive protein lymphocyte ratio (CLR) and establish an early-warning model for mortality. We retrospectively analyzed hospitalized patients in six clinical centers from May 2011 2022. The efficacy CLR prediction was evaluated receiver operating characteristic (ROC) analysis. A nomogram established validated. Eight...
The role of autologous stem cell transplantation (ASCT) in the treatment follicular lymphoma is still being defined era antibody therapy. Here we report long-term 12-year clinical outcomes patients treated with bone marrow (ABMT) for non-Hodgkin's (NHL) first remission. Between 1988 and 1993, advanced-stage NHL need initial therapy were enrolled 2 consecutive prospective trials either standard-dose CHOP induction (83 patients) or high-dose plus granulocyte-colony stimulating factor (G-CSF)...
AIM:To hypothesize that in patients with colon cancer showing heavy intestinal wall invasion without distant metastasis (T4bN0-2M0), small tumor size would correlate more aggressive behaviors and therefore poorer cancer-specific survival (CSS). METHODS:We analyzed T4bN0-2M0 the Surveillance, Epidemiology End Results (SEER) database.A preliminary analysis of at Fudan University Shanghai Cancer Center is also presented. RESULTS:A total 1734 from SEER database were included.Kaplan-Meier...
The purpose of our study was to develop a multigene signature based on transcriptome profiles both mRNAs and lncRNAs identify group patients who are at high risk early relapse in stages II-III colon cancer. Firstly, propensity score matching conducted between long-term survival from GSE39582 training series (N = 359) were matched 1:1. Global analysis then performed the paired groups tumor specific lncRNAs. Finally, using LASSO Cox regression model, we built classifier incorporating 15 three...
Abstract The rapid advancements in neuroscience highlight the pressing need to safeguard neural personal information (NPI). China has achieved significant progress brain–computer interface technology and its clinical applications. Considering intrinsic vulnerability of NPI paucity legal scrutiny concerning breaches, a thorough assessment adequacy China’s protection legislation is essential. This analysis contends that should be classified as sensitive information. absence bespoke provisions...