A5114377803- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Dermatologic Treatments and Research
- vaccines and immunoinformatics approaches
- Skin Protection and Aging
- Liver Disease Diagnosis and Treatment
- Hair Growth and Disorders
- Psoriasis: Treatment and Pathogenesis
- Vitamin D Research Studies
- Pancreatic function and diabetes
- Biochemical Analysis and Sensing Techniques
- Melanoma and MAPK Pathways
- Birth, Development, and Health
- Ion Transport and Channel Regulation
- Wound Healing and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Ferroptosis and cancer prognosis
- Cutaneous Melanoma Detection and Management
Semmelweis University
2021-2025
Harvard University
2015-2024
Hungarian Academy of Sciences
2024
Massachusetts General Hospital
2015-2024
Montavid Thermodynamic Research Group
2024
University of Szeged
2011-2023
Background & AimsExcessive consumption of ethanol is one the most common causes acute and chronic pancreatitis. Alterations to gene encoding cystic fibrosis transmembrane conductance regulator (CFTR) also cause However, little known about role CFTR in pathogenesis alcohol-induced pancreatitis.MethodsWe measured activity based on chloride concentrations sweat from patients with fibrosis, admitted emergency department because excessive alcohol consumption, healthy volunteers. We levels...
Abstract Glucose is vital for life, serving as both a source of energy and carbon building block growth. When glucose limiting, alternative nutrients must be harnessed. To identify mechanisms by which cells can tolerate complete loss glucose, we performed nutrient-sensitized genome-wide genetic screens PRISM growth assay across 482 cancer cell lines. We report that catabolism uridine from the medium enables in absence glucose. While previous studies have shown salvaged to support pyrimidine...
Although immune checkpoint inhibitors (ICIs), such as anti-programmed cell death protein-1 (PD-1), can deliver durable antitumor effects, most patients with cancer fail to respond. Recent studies suggest that ICI efficacy correlates a higher load of tumor-specific neoantigens and development vitiligo in melanoma. Here, we report low melanoma neoantigen burdens who responded had tumors expression pigmentation-related genes. Moreover, expansion peripheral blood CD8+ T populations specific for...
Epigenetic regulators, when genomically altered, may become driver oncogenes that mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic stimulus, such as activation of the WNT/β-catenin pathway in melanoma. This study identifies previously unrecognized recurrent activating mutations G9a histone methyltransferase gene, well genomic copy gains approximately 26% human melanomas, which collectively drive tumor growth and an immunologically sterile microenvironment beyond...
Abstract Immune‐mediated inflammatory disease (IMID) patients including psoriasis, arthritides and bowel diseases have a higher risk of developing cardiovascular (CV) compared to the general population. The increased CV may be promoted by tumour necrosis factor (TNF)‐α‐mediated immunological processes, which are present both in pathomechanism IMIDs atherosclerosis. Our objective was comprehensively investigate effect TNF inhibitors (TNFi) on with conventional therapies IMIDs. systematic...
Addiction to UV light and opioids is increased by VitD deficiency, suggesting that a feedback loop promotes its synthesis.
Abstract Objectives There is growing interest in measuring health outcomes associated with minimally invasive cosmetic procedures (MICPs), such as botulinum toxin and hyaluronic acid injections. However, the EQ-5D may have limited content validity for this purpose. This study aims to psychometrically test five additional dimensions (‘bolt-ons’) EQ-5D-5L individuals planning or undergoing MICPs. Methods In 2023, a cross-sectional, online survey was conducted 149 women MICPs 215 who had...
Aquaporins (AQPs) facilitate the transepithelial water flow involved in epithelial fluid secretion numerous tissues; however, their function pancreas is less characterized. Acute pancreatitis (AP) a serious disorder which specific treatment still not possible. Accumulating evidence indicate that decreased pancreatic ductal plays an essential role AP; therefore, aim of this study was to investigate physiological and pathophysiological AQPs pancreas. Expression localization were investigated...
Vitamin D receptor (VDR) has been implicated in fatty liver pathogenesis, but its role the regulation of organismal energy usage remains unclear. Here, we illuminate evolutionary function VDR by demonstrating that zebrafish Vdr coordinates hepatic and homeostasis through antagonistic nutrient storage tissue growth. Hepatocyte-specific impairment increases lipid storage, partially acsl4a induction, while simultaneously diminishing acid oxidation Importantly, exacerbates starvation-induced...
Gastrointestinal myofibroblasts are contractile, electrically nonexcitable, transitional cells that play a role in extracellular matrix production, ulcer healing, and pathophysiological conditions they contribute to chronic inflammation tumor development. Na + /Ca 2+ exchangers (NCX) known have crucial Ca homeostasis of contractile cells, however, no information is available concerning the NCX proliferation migration gastrointestinal myofibroblasts. In this study, our aim was investigate...
The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment malignant melanoma (MM). However, resistance to targeted immune-checkpoint-based therapies still poses a significant problem.
In the red-haired background, altered pain thresholds exist and are explained by distinct OPRM1/MC4R signaling.
Fatigue is a common adverse effect of external beam radiation therapy in cancer patients. Mechanisms causing fatigue remain unclear, although linkage to skin irradiation has been suggested. β-Endorphin, an endogenous opioid, synthesized following genotoxic ultraviolet and acts systemically, producing addiction. Exogenous opiates with the same receptor activity as β-endorphin can cause fatigue. Using rodent models therapy, exposing tails sparing vital organs, we tested whether skin-derived...
BCL10/MALT1 signaling in keratinocytes is altered human sporadic psoriasis and a critical initiator amplifier of skin inflammation mouse models.
Abstract The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment malignant melanoma (MM). However, resistance to targeted immune-checkpoint-based therapies still poses a significant problem. Here we mine large scale MM proteogenomic data integrating it with cell line dependency screen, drug sensitivity identify druggable targets forecast efficacy resistance. Leveraging protein profiles from established subtypes molecular structures 82 cancer drugs, identified nine...