A5072901262- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cutaneous Melanoma Detection and Management
- Traffic and Road Safety
- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Transportation Systems and Logistics
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Vehicle emissions and performance
- Hungarian Social, Economic and Educational Studies
- Complementary and Alternative Medicine Studies
- T-cell and B-cell Immunology
- Automotive and Human Injury Biomechanics
- Transportation Safety and Impact Analysis
- Dermatological and Skeletal Disorders
- Skin Protection and Aging
- Nail Diseases and Treatments
- Traffic Prediction and Management Techniques
- Risk and Safety Analysis
- Cancer Immunotherapy and Biomarkers
- Hidradenitis Suppurativa and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Acne and Rosacea Treatments and Effects
Semmelweis University
2016-2025
Phoenix Contact (United States)
2024
Roswell Park Comprehensive Cancer Center
2024
University of Debrecen
2019
Institute for Transport Sciences
1998-2018
Széchenyi István University
2014-2015
Universitätsmedizin Greifswald
2000
Background Patients with severe chronic hand eczema (CHE) refractory to topical corticosteroids currently have limited treatment options suited for use, and few controlled clinical studies investigated new therapies in this setting. Objectives To assess the efficacy safety of oral alitretinoin (9-cis retinoic acid) taken at 10 mg or 30 once daily up 24 weeks, compared placebo control, CHE corticosteroids. Methods A randomized, double-blind, placebo-controlled, prospective, multicentre trial...
Abstract Immune‐mediated inflammatory disease (IMID) patients including psoriasis, arthritides and bowel diseases have a higher risk of developing cardiovascular (CV) compared to the general population. The increased CV may be promoted by tumour necrosis factor (TNF)‐α‐mediated immunological processes, which are present both in pathomechanism IMIDs atherosclerosis. Our objective was comprehensively investigate effect TNF inhibitors (TNFi) on with conventional therapies IMIDs. systematic...
Abstract This study aims to explore the measurement agreement between direct and indirect health utility measures in four chronic dermatological conditions (atopic dermatitis, hidradenitis suppurativa, pemphigus, psoriasis). Outpatients survey data collected 2015 2021 were analysed. Health-related quality of life (HRQoL) outcome included time trade-off (TTO), EQ-5D-5L Dermatology Life Quality Index (DLQI). Descriptive statistics computed for pooled sample diseases. Mean, standard deviation...
Artificial intelligence (AI) is increasingly being explored for dermatological diagnostics [1, 2]. Patients access large language models (LLMs) automated image-based diagnosis. Acne and rosacea are common conditions that can impact quality of life yet their diagnosis be challenging due to overlapping clinical features [3]. However, the accuracy LLMs in diagnosing these remains unclear, highlighting need further validation research. This study evaluated lesions from patients treated at...
Abstract Objectives There is growing interest in measuring health outcomes associated with minimally invasive cosmetic procedures (MICPs), such as botulinum toxin and hyaluronic acid injections. However, the EQ-5D may have limited content validity for this purpose. This study aims to psychometrically test five additional dimensions (‘bolt-ons’) EQ-5D-5L individuals planning or undergoing MICPs. Methods In 2023, a cross-sectional, online survey was conducted 149 women MICPs 215 who had...
Dermatology Life Quality Index (DLQI) is the most common health-related quality of life measure in dermatology that widely used treatment guidelines for psoriasis. Eight 10 questions DLQI offer a 'not relevant' response (NRR) option scored as item had no impact on patients' at all.To explore occurrence NRRs psoriasis patients and to examine effect several socio-demographic clinical factors giving NRRs.Data were obtained from two cross-sectional surveys among academic clinics Hungary....
'Not relevant' responses (NRRs) on the Dermatology Life Quality Index (DLQI) may occur in up to 40% of patients with psoriasis. As these are scored as item questionnaire having no impact patients' lives at all, it is more difficult for fulfil DLQI > 10 criterion required by clinical guidelines become candidates systemic treatment including biologics.We propose a new scoring system that corrects bias NRR option and test its construct validity sample psoriasis.Data from 242 (104 whom marked...
© 2012 The Authors. doi: 10.2340/00015555-1249 Journal Compilation Acta Dermato-Venereologica. ISSN 0001-5555 Lichen planus (LP) is a relatively common inflammatory dermatosis (with prevalence of approximately 0.5%), characterized by violaceous, polygonal, flat pruritic papules. It can involve both skin and mucous membranes usually occurs in middle-aged persons. Mild cases heal spontaneously, but patients with widespread lesions are sometimes hard to treat. Different treatment modalities...
Persistence is an important component of therapeutic success, which depends on a variety factors. measured under optimal conditions during clinical trials does not necessarily coincide with persistence observed in the real-world settings. The aim present study was to compare rate TNF-alpha inhibitors and interleukin 12/23 inhibitor all psoriasis patients Hungary, as well analyze predictors persistence. Data collected from 1263 over period 46 months were subjected retrospective analysis. Drug...
T lymphocytes expressing the CLA antigen constitute a subset of effector memory that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking recirculate between inflamed skin and blood during inflammation. Many studies different inflammatory diseases have clearly related their pathologic mechanisms to CLA+ cells. Based on common features these cells disorders mediated by cells, we propose circulating CLA+T could very useful peripheral cellular biomarkers for
The Dermatology Life Quality Index (DLQI) rates 'not relevant' responses (NRRs) as the item on questionnaire having no impact patients' lives at all. DLQI‐Relevant (DLQI‐R) is a recently developed scoring that adjusts total score of for number NRRs indicated by patient. To compare discriminatory power original and DLQI‐R approaches in terms absolute relative informativity. Cross‐sectional data from 637 patients with morphea, pemphigus psoriasis were used analyses. assess informativity,...
Real-world evidence plays an important role in the assessment of efficacy and safety novel therapies. The increasing use immune checkpoint inhibitors (ICIs) patients with advanced melanoma has led to notably improved clinical outcomes, while they are also associated immune-related adverse events (irAEs). majority available data based on trials, where investigated subjects often do not adequately represent general patient population everyday practice. Although there is a niche objective...
Background: Basal cell carcinoma (BCC) is the most common type of skin cancer in Caucasian population. Currently, invasive biopsy only way establishing histological subtype (HST) that determines treatment options. Our study aimed to evaluate whether optically guided high-frequency ultrasound (OG-HFUS) imaging could differentiate aggressive HST BCCs from low-risk tumors. Methods: We conducted prospective clinical and dermoscopic examinations BCCs, followed by 33 MHz OG-HFUS imaging, surgical...
Abstract Background Unrealistic expectations regarding treatments and clinical outcomes may lead to disappointment about therapy sub‐optimal compliance; nonetheless, these have not been studied in psoriasis patients yet. Objective To evaluate patients' subjective future health‐related quality of life (HRQOL) expectancy, explore features associated with under‐ or overestimating behaviour. Methods A cross‐sectional questionnaire survey consecutive adult moderate severe was conducted. HRQOL...