Abstract Objective To evaluate the significance of leash attachment and device positioning along collar a commercial triaxial accelerometer (FitBark 2) on physical activity measurements during leashed walks in dogs. Methods 10 medium- to large-breed healthy dogs (1 11 years old) were enrolled for 3- 14-day period. Dogs fitted with 2 collars devices each (dorsolateral [LL], dorsolateral no [L-NL], ventral [VL], [V-NL]) that worn 6 where was only attached 1 designated collar. Device outputs...

Healthy multiparous Holstein-Friesian cows (n = 22, parity: 2-4) from a large-scale dairy herd in Hungary were subjected to an intravenous glucose tolerance test 10-15 days after calving. AluI genotype of growth hormone, several plasma metabolites and metabolic hormones determined, current previous lactation yields recorded. We also used the Revised Quantitative Insulin Sensitivity Check Index (RQUICKI) its modified version (RQUICKIBHB) for estimation peripheral insulin sensitivity. The...

To estimate the potential clinical impact and cost-effectiveness of a United Kingdom (UK) Autumn 2024 vaccination campaign with an updated Moderna COVID-19 vaccine in adults ≥65 years eligible persons 6 months to 64 age over 1-year time horizon (September 2024-August 2025).

Neoplasms of the mammary gland are among most common diseases in female domestic dogs (Canis familiaris). It is assumed that reproductive hormones influence tumorigenesis this species, although precise role endocrine milieu and state subject to continuing discussion. In line with this, a recent systematic review available data on development neoplasms revealed weak evidence for risk reduction after neutering an effect age at neutering. Investigation several hormone receptors has decreased...

Abstract Background Unrealistic expectations regarding treatments and clinical outcomes may lead to disappointment about therapy sub‐optimal compliance; nonetheless, these have not been studied in psoriasis patients yet. Objective To evaluate patients' subjective future health‐related quality of life (HRQOL) expectancy, explore features associated with under‐ or overestimating behaviour. Methods A cross‐sectional questionnaire survey consecutive adult moderate severe was conducted. HRQOL...

Contents Leptin (Lep) and insulin‐like growth factor 1 ( IGF 1) are implicated in the regulation of testicular function, but dogs, our knowledge is limited to possible role system tumours. In this study, we aimed describe compare gene expression protein localization Lep, their receptors (LepR 1R, respectively) testis healthy adult prepubertal dogs. Testes were collected from sexually mature n = 7) 8‐week‐old dogs 7). Relative LepR, 1R was determined by semi‐quantitative real‐time (TaqMan)...

Leptin (Lep) is known for its involvement in the regulation of reproductive functions. It important uterine receptivity, implantation, placental growth and maternal energy homeostasis several species, but Lep's function pregnant dog has not been investigated. Pregnant bitches were ovariohysterectomized at pre-implantation, post-implantation, mid-gestation prepartum luteolysis. Two additional groups treated with aglepristone mid-gestation, 24 or 72 h later. Lep leptin receptor (LepR) gene...

Anti-Müllerian hormone (AMH) is a biomarker for the presence of gonadal tissue. Changes in serum AMH after gonadectomy are not well established, and its half-life unknown dogs. We measured with validated electro-chemiluminescent immunoassay adult female (n = 12) male 7) dogs normal gonads, as pathology (ovarian remnant syndrome, ORS n 3, testicular tumor [Leydig cell, Sertoli seminoma] unilateral abdominal cryptorchid 4) on day (D0), D3, D7, D14 (females males), D21, D28 (males only). Males...

The use of shipping canine semen for artificial insemination has bloomed over the last 20 years. This allows spread genetic material while overcoming geographical or time-related challenges. optimal sperm concentration cooled transport in dog is unknown. Often extended 1:3–5 vol:vol without standardized concentrations shipment. We compared different storage and hypothesized that lower would result better quality. Semen was collected from healthy client-owned dogs ( n = 8). Individual...

Abstract Benefits and risks of spaying on the behaviour female dogs are controversially discussed. Increased aggressiveness male urinary were postulated to be consequence masculinization after in some dogs. To investigate if or its timing relative onset puberty may have a effect, behaviour, that is, frequency urination, posture ground scratching urination recorded 58 Labrador Retrievers during 15 min daily walk with their owners. General walks was assessed using an owner questionnaire. Data...

The role of anti-Müllerian hormone (AMH) and insulin-like peptide 3 (INSL3) in male infertility is not fully understood. We used the downregulated testis as a model gonadotropin-dependent infertility. Serum testosterone AMH concentrations were studied five adult Beagles implanted (day 0) with 4.7 mg deslorelin (Suprelorin®, Virbac) (DES group). Testicular expression LH receptor (LHR) androgen (AR), AMH, type 2 (AMHR2), INSL3 its (RXFP2) was evaluated 112 days (16 weeks) after treatment by...

Bitches with dystocia most often present clinical signs of uterine inertia (UI). The aetiology myometrial dysfunction in these cases is still not elucidated. We compared blood ionized calcium (iCa) and glucose concentrations bitches diagnosed primary UI (PUI, n = 14), secondary (SUI, 6) or obstructive (OD, 6), we described their haematology profiles. had a patent birth canal delivered no puppies yet (PUI) only part the whole litter (SUI). OD group showed strong abdominal contractions. Blood...

Our objective was to determine a clinically relevant range of centrifugation parameters for processing canine semen. We hypothesized that higher gravitational (g) force and longer time would result in improved spermatozoa recovery rate (RR) but poorer semen quality. Cooled storage under standard shipping conditions used as stressor evaluate long-term treatment effects. Individual ejaculates collected from 14 healthy dogs were split into six groups (400 g, 720 900 g 5 or 10 min). Sperm RR (%)...

Abstract Background Prurigo nodularis (PN) is a pruritic skin disease characterized by multiple intensely itchy nodules in symmetrically distributed areas of the extremities. There are limited studies on epidemiology and treatment pathways PN, especially moderate-to-severe from England. Objectives To assess mild PN Methods This retrospective cohort study used data Clinical Practice Research Datalink Hospital Episode Statistics Adult patients (aged ≥ 18 years) with PN-specific diagnosis code...

Abstract Aims To estimate the potential clinical impact and cost-effectiveness of a United Kingdom (UK) Autumn 2024 vaccination campaign with an updated Moderna COVID-19 vaccine in adults ≥65 years eligible persons 6 months to 64 age over 1-year time horizon (September 2024-August 2025). Materials methods A compartmental Susceptible-Exposed-Infected-Recovered model was adapted reflect cases UK. Numbers symptomatic infections, COVID-19– related hospitalizations deaths, costs, quality-adjusted...

Contents In cats, accuracy of parturition day prediction by ultrasonographic measurement foetal structures is decreasing towards the end gestation. Foetal measurements during last days pregnancy are scarce. We determined biparietal, abdominal and eye diameter ( BPD , AD ED respectively) ultrasonography as well maternal blood progesterone (P4) within five delivery to predict date calculate prediction. at birth was compared with newborn kitten head HD ). Kitten crown‐rump length CRL ) body...