-- (Published: 12 August 2015) Citation: Journal of Market Access & Health Policy 2015, 3: 29284 - http://dx.doi.org/10.3402/jmahp.v3.29284

Post-herpetic neuralgia (PHN) is the most common complication of herpes zoster (shingles). As a chronic condition, PHN can have substantial adverse impact on patients' lives. However, UK-specific data concerning burden individual patients, healthcare systems and wider society, are lacking. first UK-wide cross-sectional study its kind, The Zoster Quality Life (ZQOL) was designed to address these concerns.Patients (n = 152) with confirmed diagnosis (defined as pain persisting ≥ 3 months...

Herpes zoster (HZ) is a painful condition that can have substantial negative impact on patients' lives. However, UK-specific data the debilitating of HZ, in terms experience pain and impairments Health-Related Quality Life (HRQoL) are limited. The Zoster (ZQOL) study, large-scale UK cross-sectional was conducted to quantify burden HZ patients.A total 229 patients aged 50 years or over were recruited from primary secondary/tertiary care centres throughout UK. Patients completed battery...

The winter pressure often experienced by NHS hospitals in England is considerably contributed to severe cases of seasonal influenza resulting hospitalisation. prevention planning and commissioning the vaccination programme UK does not always involve those who control hospital budget. objective this study was describe direct medical costs secondary care influenza-related admissions across different age groups during two consecutive seasons.The number admissions, length stay, associated were...

To estimate the potential clinical impact and cost-effectiveness of a United Kingdom (UK) Autumn 2024 vaccination campaign with an updated Moderna COVID-19 vaccine in adults ≥65 years eligible persons 6 months to 64 age over 1-year time horizon (September 2024-August 2025).

Infectious intestinal diseases cause substantial morbidity and economic loss in the UK. Rotavirus gastroenteritis (RVGE), a form of gastroenteritis, is primary severe diarrhoea children. The objective this study was to examine whether hospitalisation for particularly RVGE, linked social deprivation.A retrospective relating hospital admissions England with rotavirus, or type 1 diabetes mellitus (T1DM) conducted children aged under 5 years between 1st April 2009 31st March 2010 using CHKS...

Objective: The introduction of routine childhood vaccination with pneumococcal conjugate vaccines (PCVs) has led to a decrease in the overall incidence disease all ages and change serotype distribution remaining disease. This study assessed cost–effectiveness vaccinating ≥65 years at risk adults either 23-valent polysaccharide vaccine (PPV23) or 13-valent (PCV13) UK, accounting for epidemiological changes. Methods: A population-based Markov model was used track one UK-based cohort...

The objectives of this research were to produce a macro-level overview the global COVID-19 burden and estimate value access vaccines. A targeted literature review collated evidence burden. Linear modelling data analysis estimated health economic effects vaccines delivered in 2021, whether additional could have been achieved with broader more equitable access. By 1 December 2020, there had an 17 million excess deaths due COVID-19. Low-income countries allocated than 30% their healthcare...

Background: A randomized phase III trial of sorafenib vs. placebo in hepatocellular carcinoma (HCC) demonstrated that significantly prolonged overall survival (OS) compared to placebo.Research design and methods: Markov model was developed evaluate the cost-effectiveness best supportive care (BSC) HCC from perspective Canadian provincial Ministry Health. The followed time progression (TTP) monthly cycles based on extrapolation patient level data. Health effects were expressed as life-years...

Peginterferon beta-1a 125 mcg administered subcutaneously every 2 weeks, a new disease-modifying therapy (DMT) for relapsing-remitting multiple sclerosis (RRMS), was approved in January 2015 by the Scottish Medicines Consortium. This study assesses long-term clinical and economic outcomes of peginterferon compared with other self-injectable DMTs (interferon [22 mcg, 30 44 mcg], interferon beta-1b, glatiramer acetate 20 mg) treatment RRMS, from National Health Service Personal Social Services...

Objectives To estimate the total costs of treating head and neck cancers, specifically oropharyngeal, laryngeal oral cavity cancer, in secondary care facilities England during period 2006/2007 to 2010/2011. Design Patient records were extracted from an English hospital database number patients treated for cancer England. Identified resource use was linked published United Kingdom cost estimates quantify reimbursement treatment through Payment by Results system. Setting Retrospective data...

The COVID-19 pandemic's dramatic impact has been a vivid reminder that vaccines-especially in the context of infectious respiratory viruses-provide enormous societal value, well beyond healthcare system perspective which anchors most Health Technology Assessment (HTA) and National Immunization Technical Advisory Group (NITAG) evaluation frameworks. Furthermore, development modified ribonucleic acid-based (mRNA-based) nanoparticle vaccine technologies brought into focus several new value...

Abstract Aims To estimate the potential clinical impact and cost-effectiveness of a United Kingdom (UK) Autumn 2024 vaccination campaign with an updated Moderna COVID-19 vaccine in adults ≥65 years eligible persons 6 months to 64 age over 1-year time horizon (September 2024-August 2025). Materials methods A compartmental Susceptible-Exposed-Infected-Recovered model was adapted reflect cases UK. Numbers symptomatic infections, COVID-19– related hospitalizations deaths, costs, quality-adjusted...

Objective:Rotavirus is a common infection affecting children under 5 years, which leads to significant disease burden. This burden potentially exacerbated by the seasonality of rotavirus, particularly in context other childhood infections. The primary study objective was describe pattern and seasonal infections amongst years age with particular attention placed on rotavirus gastrointestinal

The national cost of managing genital warts (GWs) in the UK has not been fully estimated, yet is required to inform decisions on vaccination against human papillomavirus. This study estimated 2010 costs based secondary genitourinary (GU) medicine clinic data from Health Protection Agency (HPA) and primary care Improvement Network database. Extrapolating resulted 173,077 GU 16,782 GW episodes. Using treatment patterns obtained key opinion leaders tariffs National Service Payment by Results...

In the context of current economic difficulties across Europe, accurate budgeting and resource allocation have become increasingly important. Vaccination programmes can respond to needs governments budget with confidence. It may be more reliable forecast for a vaccination programme than unpredictable seasonal disease peaks infections such as rotavirus gastroenteritis, influenza, pneumonia. addition, prevention through involves low levels investment relative substantial benefits that...

Background.The objectives of this study were (1) to investigate the extent erroneous and/or omitted information on death certificates patients implanted with Bjork-Shiley Convexo-Concave (BSCC) heart valves; (2) determine whether could be associated a possible under-reporting acute mechanical failure valve.