A5026899493- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune and Inflammatory Disorders
- Receptor Mechanisms and Signaling
- Hidradenitis Suppurativa and Treatments
- Neuropeptides and Animal Physiology
- Autoimmune Bullous Skin Diseases
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Anatomy and Medical Technology
- Body Contouring and Surgery
- Skin Protection and Aging
- Mycotoxins in Agriculture and Food
- Colorectal and Anal Carcinomas
- Abdominal Surgery and Complications
- Hair Growth and Disorders
- Lymphatic System and Diseases
- Pharmaceutical Practices and Patient Outcomes
- Dialysis and Renal Disease Management
- Pelvic and Acetabular Injuries
Corvinus University of Budapest
2020-2025
Semmelweis University
2000-2024
University of Pecs
2006-2023
National Healthcare Service Center
2023
University of California, San Francisco
2013
San Francisco VA Medical Center
2013
Differences in the lifestyle and health-service-seeking behavior of persons experiencing homelessness (PEH) are well known. However, a comprehensive estimation resulting healthcare utilization differences health outcome impacts so far under-researched, especially at national level. We aim to close this gap evidence for lung cancer within Hungarian universal system. analyzed cancer-related information PEH population central insurance register dataset matched control between 2015 2021. In...
Dermatology Life Quality Index (DLQI) and Skindex-16 are among the most commonly used dermatology-specific health-related quality-of-life (HRQoL) instruments. DLQI has two common scoring methods, original DLQI-Relevant (DLQI-R) modification. Head-to-head comparisons of measurement properties DLQI, DLQI-R currently lacking.We aim to compare Skindex-16.We analysed data from 618 patients with self-reported physician-diagnosed dermatological conditions a cross-sectional survey carried out in...
Abstract Purpose Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that affects up to 1% of the population in Europe. The EQ-5D most commonly used generic instrument for measuring health-related quality life among HS patients. This study aims compare measurement properties two adult versions (EQ-5D-3L and EQ-5D-5L) patients with HS. Methods We recruited 200 consecutive (mean age 37 years, 38% severe or very HS) participate multicentre cross-sectional survey. Patients...
Background Few studies have investigated health-related quality of life (HRQoL) in patients with atopic dermatitis (AD) during the COVID-19 pandemic. Objectives The objectives this study were to compare HRQoL adult AD before and pandemic assess measurement performance 4 measures. Methods Between 2018 2021, a multicenter, cross-sectional survey was conducted, involving 218 patients. Health-related outcomes included EQ-5D-5L, Skindex-16, Dermatology Life Quality Index (DLQI), DLQI-Relevant...
Real-world evidence plays an important role in the assessment of efficacy and safety novel therapies. The increasing use immune checkpoint inhibitors (ICIs) patients with advanced melanoma has led to notably improved clinical outcomes, while they are also associated immune-related adverse events (irAEs). majority available data based on trials, where investigated subjects often do not adequately represent general patient population everyday practice. Although there is a niche objective...
Like for other somatic tissues, isolation of a pure population stem cells has been primary goal in epidermal biology. We isolated discrete populations freshly obtained human neonatal keratinocytes (HNKs) using previously untested candidate cell markers aldehyde dehydrogenase (ALDH) and CD44 as well the studied combination integrin α6 CD71. An vivo transplantation assay combined with limiting dilution analysis was used to quantify enrichment long-term repopulating populations. The ALDH(+)...
Alternariol (AOH) is a mycotoxin which occurs in wine and tomato products as contaminant. Cyclodextrins (CDs) are ring-shaped glucose oligomers. CD polymers seem to be suitable for the removal of certain mycotoxins from aqueous solutions, including different beverages. In our recent study, insoluble β-CD bead polymer (BBP) almost completely removed AOH solutions (pH 3.0–7.4). this time- temperature-dependence AOH-BBP interaction well regenerability after binding were examined. Furthermore,...
Abstract Purpose Eight of the ten items Dermatology Life Quality Index (DLQI) have a ‘not relevant’ response (NRR) option. There are two possible ways to interpret NRRs: they may be considered at all’ or missing responses. We aim compare measurement performance DLQI in psoriasis patients when NRRs scored as ‘0’ (hereafter zero-scoring) and ‘missing’ missing-scoring) using Rasch model analysis. Methods Data 425 with from earlier cross-sectional surveys were re-analysed. All completed...
Background: Psoriasis is frequently accompanied by cardiovascular diseases based on the shared immunopathogenic pathway. Authors determined effect of interleukin (IL)-17 inhibitor therapy arterial intima-media thickness (IMT) among severe psoriatic patients. Methods: Thirty-one patients were enrolled. Twenty received secukinumab and 11 ixekizumab. Before treatment initiation after 6 months, carotid-brachial-femoral IMT, Area Severity Index (PASI), Dermatology Life Quality (DLQI) EuroQol...
Two bolt-on dimensions (skin irritation, self-confidence) have been developed for the EQ-5D-5L to improve its content validity and responsiveness in psoriasis. However, two bolt-ons are not strictly psoriasis-specific potentially relevant other skin conditions. This study aims explore of with patients atopic dermatitis (AD).
BACKGROUND: Psoriasis is frequently accompanied by metabolic syndrome. Effect of anti-tumor necrosis factor therapies on increases in body weight well-known. Data the effects interleukin-17 inhibitors are limited. Authors determined effect anti-interleukin-17 composition and serum lipid inflammatory parameters among severe psoriatic patients. METHODS: Thirty-five patients were enrolled. Twenty-two received secukinumab 13 ixekizumab as their 2nd-or 3rd-line biological treatment. Before...
Numerous in vitro and vivo models of Parkinson's disease (PD) demonstrate that pituitary adenylate cyclase-activating polypeptide (PACAP) conveys its strong neuroprotective actions mainly via specific PAC1 receptor (PAC1R) PD. We recently described the decrease PAC1R protein content basal ganglia macaques 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model PD was partially reversed by levodopa therapy. In this work, we tested whether these observations occur also rotenone rat. The...
Background: The systemic treatment of advanced cutaneous squamous cell carcinoma (cSCC) has seen significant developments in recent years. anti-PD1 inhibitor cemiplimab demonstrated efficacy clinical trials, but real-world data are still limited. Here, we aimed to evaluate the and safety a setting. Methods: A retrospective analysis was carried out for all patients who received at least two doses our department between February 2020 January 2023. Progression-free survival (PFS), overall (OS),...
Összefoglaló. Bevezetés: Magyarországon 100 000 olyan értelmi sérült él, akik speciális ellátásra szorulnak. Előzőleg beszámoltunk az akut fogászati ellátás eredményeiről és problémáiról. Ahhoz azonban, hogy a teljes rehabilitáció felé lépéseket lehessen tenni, ismerni kell ilyen betegek állapotát. Célkitűzés: Statisztikailag releváns, nagyobb beteganyagon felmérni állapotát, összehasonlítva mind orvosi rehabilitációs kezelésben részesülő (főleg testi fogyatékosok), általános populáció...
The systemic nature of the inflammatory processes in psoriasis is now widely accepted. It known that IL-23/ Th-17 axis plays a pivotal role development skin and joint symptoms, which immune overlap with pathways involved pathogenesis cardiometabolic comorbidities at several points. IL-17 inhibitor biological therapies are frontline treatments for moderate-to-severe have also been focus interest recent years because their potential effects on comorbidities. In this review we aim to describe...
Background, aims: Genetic polymorphisms of angiogenesis, steroid hormon receptor, inflammatory cascade, apoptosis controlling genes can influence the gastric erosive complications diabetic uraemic patients. Parallel evaluation multiple genetic polymorphism became available with development DNA sequencing arrays. We aimed to develop a 17 gene, 17561 nucleotid array for prediction these complications. Methods: was isolated from 10ml peripheral blood 40 non ureamic and uremic patients 37 amoung...
The Hartmann procedure - primarily was introduced for the treatment of cancerous diseases sigmoid colon and rectum. In last few years it performed in cases with complicated inflammation left colon, cancers bowel obstruction or perforation, case insufficiency anastomoses, urgent operations after traumatics injuries, when making anastomosis is at very high risk. Later on restoration continuity GI tract can be done traditionally (by laparotomy) laparoscopically. We present our experiences above...