A5089577588- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Lanthanide and Transition Metal Complexes
- Atherosclerosis and Cardiovascular Diseases
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Oropharyngeal Anatomy and Pathologies
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related cognitive impairment studies
- Coronary Interventions and Diagnostics
- Moyamoya disease diagnosis and treatment
- Renal and Vascular Pathologies
- Psoriasis: Treatment and Pathogenesis
- Blood Pressure and Hypertension Studies
- Macrophage Migration Inhibitory Factor
Semmelweis University
2016-2025
University Medical Center Utrecht
2017
Oregon Health & Science University
2009-2013
Charité - Universitätsmedizin Berlin
2013
University of Basel
2013
University Medical Center Freiburg
2013
Universitätsklinikum Knappschaftskrankenhaus Bochum
2013
University of Florida
2013
The University of Texas Southwestern Medical Center
2013
National Cancer Institute
2013
To describe and correlate neurotoxicity indicators in long-term primary CNS lymphoma (PCNSL) survivors who were treated with high-dose methotrexate-based regimens or without whole-brain radiotherapy (WBRT).Eighty PCNSL from 4 treatment groups (1 WBRT 3 WBRT) a minimum of 2 years after diagnosis complete remission underwent prospective neuropsychological, quality-of-life (QOL), brain MRI evaluation. Clinical characteristics compared among treatments by using the χ(2) test analysis variance....
Macrophages play a critical role in cerebral aneurysm formation and rupture. The purpose of this study is to demonstrate the feasibility optimal parameters imaging macrophages within human wall using ferumoxytol-enhanced MRI.Nineteen unruptured aneurysms 11 patients were imaged T2*-GE-MRI sequence. Two protocols used. Protocol A was an infusion 2.5 mg/kg ferumoxytol at day 0 1. B 5 3. All images reviewed independently by 2 neuroradiologists assess for ferumoxytol-associated loss MRI signal...
Age-related disorders are closely linked to the accumulation of senescent cells. The senescence-associated secretory phenotype (SASP) sustains and progresses chronic inflammation, which is involved in cellular tissue dysfunction. SASP-related growth differentiation factor-15 (GDF-15) an immunoregulatory cytokine that coupled aging thus may have a regulatory role development maintenance atherosclerosis, major cause cardiovascular disease (CVD). Although effects GDF-15 tissue-specific...
Background and Purpose— Central nervous system vascular malformations (VMs) result from abnormal vasculo- and/or angiogenesis. Cavernomas arteriovenous are also sites of active inflammation. The aim this study was to determine whether MRI detection VMs can be improved by administration ferumoxytol iron oxide nanoparticle, which acts as a blood pool agent at early time points an inflammatory marker when taken up tissue macrophages. Methods— Nineteen patients (11 men, 8 women; mean age, 47.5...
<h3>Objective:</h3> The study goal was to assess the benefits and potential limitations in use of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles MRI diagnosis CNS inflammatory diseases primary lymphoma. <h3>Methods:</h3> Twenty patients with presumptive or known lesions underwent study. Eighteen received both gadolinium-based contrast agents (GBCAs) 1 2 USPIO (ferumoxytol ferumoxtran-10) 24 hours apart, which allowed direct comparative analysis. remaining had only...
OBJECTIVE. Ferumoxytol, an ultrasmall superparamagnetic iron oxide particle, has been suggested as a potential alternative MRI contrast agent in patients with renal failure. We compared ferumoxytol to gadoteridol enhancement on T1- and T2-weighted CNS disorders explore its diagnostic utility.
This study aims to compare gadoteridol with ferumoxytol for contrast-enhanced and perfusion-weighted (PW) MRI of intracranial tumors.The final analysis included 26 patients, who underwent 3 consecutive days 3T MRI.Day 1 consisted anatomical pre-and postcontrast images, PW was acquired using (0.1 mmol/kg).On Day 2, the same sequences were obtained (510 mg) on 3, images repeated detect delayed ferumoxytol-induced signal changes.The T -weighted evaluated qualitatively quantitatively enhancement...
Mannose-binding lectin (MBL) is thought to influence the pathophysiology of cardiovascular disease by decreasing risk advanced atherosclerosis and contributing enhanced ischemia reperfusion injury. Thus, we investigated role MBL in restenosis after eversion endarterectomy patients with severe carotid atherosclerosis.In a prospective study, 123 who underwent were followed-up duplex scan (CDS) sonography for 14 months. In retrospective examined 17 29 patients, respectively, had or not at least...
Oxidative stress is an important factor in the pathomechanism of atherosclerosis. Advanced oxidation protein products (AOPPs) are considered markers oxidative stress. Thickening carotid intima-media layers indicates subclinical atherosclerosis and can be detected by ultrasound.Our aim was to examine association between thickness (CIMT) level AOPPs.Carotid duplex scans measurements AOPPs were performed on 476 participants a cardiovascular population study. The presence conventional risk...
Purpose To evaluate factors associated with pseudoaneurysm (PSA) development. Methods Between January 2016 and May 2020, 30,196 patients had invasive vascular radiological or cardiac endovascular procedures that required arterial puncture. All PSA were identified. A matched (age, gender, type of the procedure) control group 134 was created to reveal predictors formation. Results Single PSAs found in patients. Fifty-three developed after (53/6555 [0.8%]), 31 coronary artery (31/18038 [0.2%]),...
To evaluate the effect of rituximab monoclonal antibody (mAb) on MRI tumor volumetrics and efficacy in a rat model central nervous system (CNS) lymphoma when delivery to brain was optimized with osmotic blood-brain barrier disruption (BBBD).Female nude rats intracerebral MC116 human B-cell xenografts underwent baseline were randomized into 5 groups (n = 6 per group): (i) BBBD saline control; (ii) methotrexate BBBD; (iii) (iv) (v) intravenous rituximab. Tumor volumes assessed by at 1 week,...
ObjectivesThe purpose of this retrospective cohort study was to determine the early and long-term mortality morbidity as well reveal risk factors influencing prognosis in patients with complicated acute type B aortic dissection (CABAD) undergoing open surgical suprarenal fenestration (OSSAF).MethodsFifty-two CABAD, defined (impending) rupture, enlargement false lumen, malperfusion, and/or unrelenting back pain or uncontrollable hypertension despite maximum medical therapy were treated by...
Cisplatin neuro-, oto-, and nephrotoxicity are major problems in children with malignant tumors, including medulloblastoma, negatively impacting educational achievement, socioemotional development, overall quality of life. The blood-labyrinth barrier is somewhat permeable to cisplatin, sensory hair cells cochlear supporting highly sensitive this toxic drug. Several chemoprotective agents such as N-acetylcysteine (NAC) were utilized experimentally avoid these potentially serious life-long...
Background: Psoriasis is frequently accompanied by cardiovascular diseases based on the shared immunopathogenic pathway. Authors determined effect of interleukin (IL)-17 inhibitor therapy arterial intima-media thickness (IMT) among severe psoriatic patients. Methods: Thirty-one patients were enrolled. Twenty received secukinumab and 11 ixekizumab. Before treatment initiation after 6 months, carotid-brachial-femoral IMT, Area Severity Index (PASI), Dermatology Life Quality (DLQI) EuroQol...
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, atherosclerosis key factor promoting its development. Carotid intima-media thickening presence carotid plaques are important indices cardiovascular risk. In addition, inflammation a major complex in development atherosclerosis. The relationships between certain inflammatory markers have rarely been studied healthy individuals. Therefore, we aimed to investigate associations subclinical various biomarkers...
To estimate overall survival (OS), progression-free (PFS), imaging responses, and toxicities of bevacizumab plus carboplatin for the treatment recurrent malignant glioma. The secondary objective was to agreement between postcontrast T1-weighted T2-weighted magnetic resonance imaging.A retrospective analysis 9 patients who received (10 mg/kg intravenously) (AUC 5 glioma (World Health Organization grades III IV) is presented. Eight this regimen at first recurrence.The median age Karnofsky...
To determine the long-term patency of aortoiliac kissing stents and to identify predisposing factors for development in-stent restenosis (ISR).A retrospective analysis was conducted 105 patients (median age 60.9 years; 64 women) with symptomatic occlusive disease who had implanted between 2001 2015. The indication severe claudication in 91 (86.7%) critical limb ischemia 14 (13.3%). Lesions were TASC A 52 (49.5%), B 29 (27.6%), C 4 (3.8%), D 20 (19%) patients. Twenty-five (23.8%) heavily...