A5071023513- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Advanced X-ray and CT Imaging
- Cardiac Health and Mental Health
- Adipose Tissue and Metabolism
- Neonatal and fetal brain pathology
- Health and Wellbeing Research
- Neonatal Respiratory Health Research
- Radiation Dose and Imaging
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- S100 Proteins and Annexins
- Cardiovascular Disease and Adiposity
- Radiology practices and education
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Nuclear Receptors and Signaling
- Mechanical Circulatory Support Devices
- Pluripotent Stem Cells Research
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Macrophage Migration Inhibitory Factor
- Statistical Methods and Inference
- Blood Pressure and Hypertension Studies
Semmelweis University
2016-2025
Government of Hungary
2023-2024
Pázmány Péter Catholic University
2024
University of Pannonia
2021
Hungarian Academy of Sciences
2017
Shaheed Rajaei Cardiovascular Medical and Research Center
2012
University of Naples Federico II
2012
KU Leuven
2012
Istanbul Florence Nightingale Hospital
2012
Oslo University Hospital
2012
Age-related disorders are closely linked to the accumulation of senescent cells. The senescence-associated secretory phenotype (SASP) sustains and progresses chronic inflammation, which is involved in cellular tissue dysfunction. SASP-related growth differentiation factor-15 (GDF-15) an immunoregulatory cytokine that coupled aging thus may have a regulatory role development maintenance atherosclerosis, major cause cardiovascular disease (CVD). Although effects GDF-15 tissue-specific...
Background and aimsVisceral obesity is a marker of dysfunctional adipose tissue ectopic fat infiltration. Many studies have shown that visceral dysfunction has close relationship with cardiovascular disease. For better identification adiposity dysfunction, the index (VAI) used. Coronary artery calcium score (CACS) known to strong correlation total plaque burden therefore provides information about severity coronary atherosclerosis. CACS predictor cardiac events it refines risk assessment...
Several inflammatory biomarkers were found to be associated with an increased risk of cardiovascular disease. Neutrophil-to-lymphocyte ratio (NLR) is a marker subclinical inflammation that increases the stress response. Visceral adiposity index (VAI) calculated as combination anthropometric and metabolic parameters reflects both extent function visceral adipose tissue. Given association obesity diseases, it plausible inflammation-CVD modulated by amount Thus, our aim was examine between NLR...
Cardiovascular diseases (CVDs) are the leading cause of death among elderly people. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important regulator cholesterol metabolism. Herein, we investigated role PCSK9 in age-related CVD. Both humans and rats, blood level correlated positively with increasing age development cardiovascular dysfunction. Age-related fatty degeneration liver tissue serum levels rat model, while nonalcoholic disease functional impairment. Network analysis...
Abstract Background/Introduction Accurate assessment of left ventricular (LV) and right (RV) systolic function is crucial in managing people with congenital heart disease (CHD), but can be challenging given the vast anatomic heterogeneity varied surgical history this population. While 3D echocardiography (3DE) most reproducible best-validated echocardiographic technique for assessing biventricular function, it requires special equipment expertise not feasible patients poor acoustic windows....
Abstract Background Diastolic dysfunction (DD) often precedes symptomatic heart failure and is a predictor of adverse outcomes; thus, accurate assessment grading are crucial for early interventions. Current guidelines recommend combining multiple echocardiographic parameters, including left atrial volume index (LAVi), diagnosing DD in patients with normal ventricular ejection fraction (LVEF). Recently, reservoir strain (LASr) emerged as more sensitive marker function, although its added...
Abstract Background 2D echocardiography requires multiple views for the assessment of left ventricular (LV) systolic function and does not enable calculation right (RV) ejection fraction (EF). 3D (3DE) has clear incremental value over echocardiography; nevertheless, its availability feasibility is limited. Purpose We aimed to develop a dual-task deep learning model – EF2Net predicting 3DE-derived LVEF RVEF from apical 4-chamber (A4C) view echocardiographic videos. Methods The comprises two...
The rapid growth of web-based symptom checkers (SCs) is not matched by advances in quality assurance. Currently, there are no widely accepted criteria assessing SCs' performance. Vignette studies used to evaluate SCs, measuring the accuracy outcome. Accuracy behaves as a composite metric it affected number individual SC- and tester-dependent factors. In contrast clinical studies, vignette have small testers. Hence, alone may provide reliable assessment performance due tester variability.
Oxidative stress is an important factor in the pathomechanism of atherosclerosis. Advanced oxidation protein products (AOPPs) are considered markers oxidative stress. Thickening carotid intima-media layers indicates subclinical atherosclerosis and can be detected by ultrasound.Our aim was to examine association between thickness (CIMT) level AOPPs.Carotid duplex scans measurements AOPPs were performed on 476 participants a cardiovascular population study. The presence conventional risk...
The phosphatase and actin regulator 1 (PHACTR1) locus is a very commonly identified hit in genome-wide association studies investigating coronary artery disease myocardial infarction (MI). However, the function of PHACTR1 heart still unknown. We characterized mechanisms regulating Phactr1 expression heart, used adenoviral gene delivery to investigate effects on cardiac function, analyzed relationship between MI associated allele human subjects. mRNA protein levels were markedly reduced (60%,...
AimsThe low lymphocyte counts and high neutrophil leucocyte fractions have been associated with poor prognosis in chronic heart failure. We hypothesized that the baseline ratio of leucocytes to lymphocytes (NL ratio) would predict outcome failure patients undergoing cardiac resynchronization therapy (CRT).
Detecting early-stage atherosclerosis is an important step towards cardiovascular disease prevention. Coronary artery calcium (CAC) score a sensitive and non-invasive tool for detecting coronary atherosclerosis. Higher serum uric acid (SUA) levels are known to be associated with diseases. However, there inconsistency regarding the independence of association. The aim our study was assess association CAC SUA in asymptomatic population. scans 281 participants were analyzed voluntary screening...
Structured reporting in cardiac imaging is strongly encouraged to improve quality through consistency. The Coronary Artery Disease - Reporting and Data System (CAD-RADS) was recently introduced facilitate interdisciplinary communication of coronary CT angiography (CTA) results. We aimed assess the agreement between manual automated CAD-RADS classification using a structured platform.Five readers prospectively interpreted 500 angiographies platform that automatically calculates score based on...
Human embryonic stem cell-derived endothelial cells (hESC-EC), as well other cell derived cells, have a range of applications in cardiovascular research and disease treatment. Endothelial sense Gram-negative bacteria via the pattern recognition receptors (PRR) Toll-like receptor (TLR)-4 nucleotide-binding oligomerisation domain-containing protein (NOD)-1. These pathways are important terms sensing infection, but TLR4 is also associated with vascular inflammation atherosclerosis. Here, we...
Vascular derivatives of human embryonic stem cells (hESC) are being developed as sources tissue-specific for organ regeneration. However, identity developmental pathways that modulate the specification endothelial is not known yet. We studied phosphatidylinositol 3-kinase (PI3K)-Forkhead box O transcription factor 1A (FOXO1A) during differentiation hESC toward lineage and on proliferation, maturation, cell death hESC-derived (hESC-EC). During hESC, expression FOXO1A was linked to a cluster...
Bevezetés: A cardiovascularis rizikó csökkentésére irányuló megelőző erőfeszítések ellenére a szív- és érrendszeri halálozás mértéke nő. rendszerszintű, protokolláris, kibővített szűrés működtetése lehet egy olyan populációs stratégia, amelynek hosszú távú hatása hozzájárulhat mortalitás csökkenéséhez. Célkitűzés: jelen tanulmány célja, hogy Budakalász Epidemiológiai Vizsgálat (BEV) utánkövetéseként megvizsgáljuk résztvevők 2012 2019 között történt egészségmagatartás-változását. Módszer:...
Background . In-stent restenosis (ISR) is the gradual narrowing of vessel lumen after coronary stent implantation due to increase in vascular smooth muscle cell proliferation. Vascular endothelial growth factor (VEGF) protein plays an important role this process. Our aim was analyze association single nucleotide polymorphisms VEGF gene (rs2010963 and rs6999447) with occurrence ISR artery bare metal (BMS) implantation. Methods 205 patients a history BMS repeated coronarography were...
Introduction: The reduction in mortality due to prevention programmes observed some European countries is not currently reached Hungary. Effective based on the screening of risk factors and health state population. Aim: goal this study was develop a longitudinal, population-based programme Central Hungarian region order collect information cardiovascular profile citizens discover new potential factors. Method: Budakalász Study self-voluntary involving adult population (>20 yrs, approx....
Absztrakt: Bevezetés: A cardiovascularis megbetegedések vezető haláloki tényezőként évente 4 millió halált okoznak Európában. Az életmód mellett 25–40%-ra becsülik a pszichoszociális tényezők szerepét betegség létrejöttében. felnőttkori szociális izoláció krónikus stressz forrása, és másfélszeres rizikót jelent kialakulására. társas támogatás alacsony szintje növeli depresszió, magas vérnyomás az elhízás valószínűségét, ezáltal növelve szív- érrendszeri előfordulását is. Célkitűzés: jelen...
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, atherosclerosis key factor promoting its development. Carotid intima-media thickening presence carotid plaques are important indices cardiovascular risk. In addition, inflammation a major complex in development atherosclerosis. The relationships between certain inflammatory markers have rarely been studied healthy individuals. Therefore, we aimed to investigate associations subclinical various biomarkers...
Introduction: Relaxin-1 (RLN1) has emerged as a possible therapeutic target in myocardial fibrosis due to its anti-fibrotic effects. Previous randomized clinical trials investigated role of exogenous relaxin patients with acute-on-chronic heart failure (HF) and failed meet endpoints. Here, we aimed assess endogenous, circulating RLN1 levels reduced ejection fraction (HFrEF) ischemic origin. Furthermore, analyzed relation left ventricular diastolic function, right fibrosis, invasive...
<sec> <title>BACKGROUND</title> The rapid growth of web-based symptom checkers (SCs) is not matched by advances in quality assurance. Currently, there are no widely accepted criteria assessing SCs’ performance. Vignette studies used to evaluate SCs, measuring the accuracy outcome. Accuracy behaves as a composite metric it affected number individual SC- and tester-dependent factors. In contrast clinical studies, vignette have small testers. Hence, alone may provide reliable assessment...