A5046461082- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver physiology and pathology
- Liver Diseases and Immunity
- Peroxisome Proliferator-Activated Receptors
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Plant Virus Research Studies
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease and Transplantation
- Lipid metabolism and disorders
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Studies on Chitinases and Chitosanases
- Trace Elements in Health
- Immune Cell Function and Interaction
- Plant-Microbe Interactions and Immunity
- Circular RNAs in diseases
- Cannabis and Cannabinoid Research
- Cancer, Lipids, and Metabolism
Hebei Medical University
2016-2025
Third Hospital of Hebei Medical University
2016-2025
The Sixth People's Hospital of Zhengzhou
2025
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
National Institute on Alcohol Abuse and Alcoholism
2019-2023
National Institutes of Health
2019-2023
Shandong Academy of Agricultural Sciences
2022
Hospital of Hebei Province
2022
302 Military Hospital of China
2008-2011
Neutrophil infiltration around lipotoxic hepatocytes is a hallmark of nonalcoholic steatohepatitis (NASH); however, how these 2 types cells communicate remains obscure. We have previously demonstrated that neutrophil-specific microRNA-223 (miR-223) elevated in to limit NASH progression obese mice. Here, we this elevation miR-223 was due preferential uptake miR-223–enriched extracellular vesicles (EVs) derived from neutrophils as well other cells, albeit lesser extent. This selective...
Objective. Hepatic oxidative stress plays a key role in the development of non-alcoholic steatohepatitis (NASH). However, protective effects antioxidants on NASH are largely unknown. The aim this study was to elucidate effect and mechanism mice. Material methods. C57BL6/J mice were fed methionine-choline-deficient (MCD) diet for 10 days or 3 weeks induce steatohepatitis. Antioxidants (vitamin E, ABT, vitamin E plus ABT) supplemented MCD diet, respectively. apoptosis assessed, activation...
Abstract Nonalcoholic fibrosing steatohepatitis is a uniform process throughout nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) have been suggested to modulate cellular processes in diseases. However, the functional role of miRNAs largely unclear. In this study, we systematically analyzed hepatic by microarray analysis C57BL/6J mice induced methionine-choline deficient (MCD) diet. We identified 19 up-regulated and 18 down-regulated with fibrosis. Among these dysregulated miRNAs,...
Nonalcoholic fibrosing steatohepatitis is a uniform process that occurs throughout nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) have been shown to be involved in the biological processes, but role and molecular mechanism of miRNAs NAFLD are not entirely clear. In this study, we observed significant reduction expression miR-130a-3p livers mouse model with fibrosis induced by methionine-choline-deficient diet, patients, activated hepatic stellate cells (HSCs). A dual-luciferase...
Background and Aims Hepatic cardiomyopathy, a special type of heart failure, develops in up to 50% patients with cirrhosis is major determinant survival. However, there no reliable model hepatic cardiomyopathy mice. We aimed characterize the detailed hemodynamics mice bile duct ligation (BDL)–induced liver fibrosis, by monitoring echocardiography intracardiac pressure–volume relationships myocardial structural alterations. Treatment selective cannabinoid‐2 receptor (CB 2 ‐R) agonist, known...
Abstract Background Heme oxygenase 1 (HO-1) has an influential but insufficiently investigated effect on ferroptosis, which is a novel form of programmed cell death and may play nonalcoholic steatohepatitis (NASH). However, the understanding mechanism limited. Herein, our study aimed to explore role HO-1 in NASH ferroptosis. Methods Hepatocyte conditional knockout (HO-1 HEPKO ) C57BL/6J mice were established fed high-fat diet (HFD). Additionally, wild-type either normal or HFD. Hepatic...
Cardiovascular diseases (CVDs) are the leading cause of death among elderly people. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important regulator cholesterol metabolism. Herein, we investigated role PCSK9 in age-related CVD. Both humans and rats, blood level correlated positively with increasing age development cardiovascular dysfunction. Age-related fatty degeneration liver tissue serum levels rat model, while nonalcoholic disease functional impairment. Network analysis...
Background and aims This research aimed to examine the association between hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) liver inflammation in chronic (CHB) infection patients. Methods From August 2013 June 2022, CHB patients at Hebei Medical University Third Hospital (Hebei, China) were recruited. Intrahepatic cccDNA was quantified its with analyzed. Liver assessed using Ishak-modified histological activity index (HAI). Biochemical viral indicators as well hepatic...
Objective: To understand the prevalence and related factors of three common chronic diseases, hyperlipidemia, hypertension diabetes in HIV-infected persons. Methods: As December 2023, persons >15 years old who are receiving antiviral therapy (ART) follow-up Henan Province were selected as study objects. Questionnaires, physical examinations, blood samples collected to collect demographic information, ART, body weight, lipids, pressure, sugar The logistic regression model was used analyze...
Yue-Min Nana*, Na Fua, Wen-Juan Wua, Bao-Li Lianga, Rong-Qi Wanga, Su-Xian Zhaoa, Jing-Min Zhaob & Jun Yucda Department of Traditional and Western Medical Hepatology, the Third Hospital Hebei University, Shijiazhuang, Chinab Pathology, Beijing 302 Hospital, Beijing, Chinac Institute Digestive Disease Li Ka Shing Health Sciences, Medicine Therapeutics, The Chinese University Hong Kong, Kongd Gastroenterology, First China
Abstract Background Peroxisome proliferator activated receptor alpha (PPARα) regulates lipids metabolism and inhibits inflammatory response. However, the role of PPARα in alcoholic liver disease is largely unknown. We aim to elucidate effect molecular basis ethanol induced hepatic injury mice. Results C57BL/6J mice fed with 4% ethanol-containing Lieber-DeCarli liquid diet for 12 weeks exhibited hepatocyte steatosis, necrosis infiltration, accompanied elevated serum alanine aminotransferase...
Peroxisome proliferator activated receptor alpha (PPARα) ameliorates ethanol induced hepatic steatohepatitis. However, its role in alcoholic liver fibrosis has not been fully clarified. The aim of this study was to elucidate the effect and molecular basis PPARα mice. C57BL/6J mice were fed with 4% ethanol-containing Lieber-DeCarli liquid diet for eight weeks, intraperitoneal injected 5% carbon tetrachloride (CCl4) last four weeks induce fibrosis. agonist WY14643 administered during couple...
Objective. The pathogenesis of non-alcoholic steatohepatitis is still unclear. We have demonstrated previously that peroxisome proliferator activated receptor gamma (PPARγ) ligand protects against inflammation and fibrogenesis in experimental steatohepatitis. aim to elucidate the effect mechanism PPARγ itself on nutritional fibrotic mice. Methods. C57BL/6J mice were fed with methionine-choline deficient (MCD) diet for 8 weeks induce Mice MCD treated adenovirus carrying (Ad-PPARγ), Ad-PPARγ...
Objective. Lipopolysaccharide (LPS) is suspected to trigger primary biliary cirrhosis (PBC) in susceptible individuals, yet the precise mechanism of its effect PBC remains largely unknown. The aim this study was investigate altered responses LPS ligand for Toll-like receptors (TLRs) pathogenesis vivo and vitro. Material methods. In vivo, we investigated levels pro-inflammatory cytokines sera expression liver tissues from 162 patients with PBC, 325 other diseases 80 healthy controls. vitro,...
Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, has been reported to have potential antioxidant properties. However, role of HO-1 on hepatocyte apoptosis remains unclear. We aim elucidate effects oxidative stress related hepatocellular nutritional steatohepatitis mice. C57BL/6J mice were fed with methionine-choline deficient (MCD) diet for four weeks induce hepatic steatohepatitis. chemical inducer (hemin), inhibitor zinc protoporphyrin IX (ZnPP-IX) and/or adenovirus...
Objective To evaluate whether gamma-glutamyl transpeptidase to platelet ratio index (GPRI) can diagnose the extent of liver fibrosis in Chinese patients with chronic hepatitis B (CHB) infection. Methods This prospective observational study used biopsy results as gold standard ability GPRI predict hepatic compared two other markers, aspartate aminotransferase (AST) (APRI) and fibrosis-4 score (FIB-4). The clinical demographic factors that affected GPRI, independent fibrosis, were assessed...
Interleukin-23 (IL-23) and its downstream factor IL-17 are the key cytokines involved in immune inflammatory response chronic liver diseases. This study aimed to investigate role molecular mechanisms of IL-23/Th17 axis hepatitis C virus (HCV) infection, efficacy modulation anti-HCV therapy. Sixty-six HCV-infected patients 20 healthy controls were enrolled. The received PegIFNa-2a ribavirin therapy for at least 48 weeks. plasma level IL-23 number IL-17A-, IFN-γ-, IL-21-producing peripheral...
Abstract Primary biliary cholangitis (PBC) is an autoimmune disease characterized by chronic destruction of the bile ducts. A major unanswered question regarding pathogenesis PBC precise mechanisms small duct injury. Emperipolesis one cell‐in‐cell structures that a potential histological hallmark associated with hepatitis B. This study aimed to clarify and characteristics emperipolesis in liver Sixty‐six patients, diagnosed biopsy combined laboratory test, were divided into early‐stage...
Fuzheng Huayu recipe (FZHY), a compound of Chinese herbal medicine, was reported to improve liver function and fibrosis in patients with hepatitis B virus infection. However, its effect on nutritional fibrosing steatohepatitis is unclear. We aimed elucidate the role molecular mechanism FZHY this disorder mice.C57BL/6 J mice were fed methionine-choline deficient (MCD) diet for 8 weeks induce steatohepatitis. and/or heme oxygenase-1 (HO-1) chemical inducer (hemin) administered mice,...