A5015324273- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiovascular and exercise physiology
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Sports Performance and Training
- Transplantation: Methods and Outcomes
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Liver Disease Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Sports injuries and prevention
- Hemodynamic Monitoring and Therapy
- Elasticity and Material Modeling
- Body Composition Measurement Techniques
- Employment and Welfare Studies
- Neuroscience and Neuropharmacology Research
Semmelweis University
2019-2025
Pázmány Péter Catholic University
2022-2024
University of Debrecen
2024
IRCCS Istituto Auxologico Italiano
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Amsterdam University Medical Centers
2023
St. Antonius Ziekenhuis
2023
Harefield Hospital
2023
Guy's and St Thomas' NHS Foundation Trust
2023
London School of Economics and Political Science
2023
Evidence has shown the independent prognostic value of right ventricular (RV) function, even in patients with left-sided heart disease. The most widely used imaging technique to measure RV function is echocardiography; however, conventional 2-dimensional (2D) echocardiographic assessment unable leverage same clinical information that 3-dimensional (3D) echocardiography-derived ejection fraction (RVEF) can provide.
•Global RV function is determined by different motion components.•Longitudinal, radial, and anteroposterior may be of comparable significance.•Age other anthropometric factors correlate with deformation pattern.•Elderly individuals show a distinct pattern. BackgroundGlobal right ventricular (RV) the interplay components related to myofiber architecture, relative importance these still not thoroughly characterized. The aims this study were quantify contributions longitudinal, global examine...
Three-dimensional (3D) echocardiography-derived right ventricular (RV) ejection fraction (EF) and global longitudinal strain (GLS) are valuable RV functional markers; nevertheless, they substantially load-dependent. Global myocardial work index (GMWI) is a novel parameter calculated by the area of pressure-strain loop. By adjusting deformation to instantaneous pressure, it may reflect contractility.To test this hypothesis, we enrolled 60 patients who underwent pressure-conductance...
We sought to investigate the correlation between speckle-tracking echocardiography (STE)-derived myocardial work (MW) and invasively measured contractility in a rat model of athlete's heart. also assessed MW elite athletes explored its association with cardiopulmonary exercise test (CPET)-derived aerobic capacity.Sixteen rats underwent 12-week swim training program were compared controls (n = 16). STE was performed assess global longitudinal strain (GLS), which followed by invasive...
Three main mechanisms contribute to global right ventricular (RV) function: longitudinal shortening, radial displacement of the RV free wall (bellows effect), and anteroposterior shortening (as a consequence left contraction). Since importance these may vary in different cardiac conditions, technology being able assess their relative influence on pump function could help clarify pathophysiology mechanical adaptation chamber. Previously, we have introduced our 3D echocardiography (3DE)-based...
Abstract Aims While left ventricular (LV) adaptation to regular, intense exercise has been thoroughly studied, data concerning the right (RV) mechanical changes and their continuum with athletic performance are scarce. The aim of this study was characterize biventricular morphology function relation sex, age, sports classes in a large cohort elite athletes using three-dimensional (3D) echocardiography. Methods results Elite, competitive (n = 422) healthy, sedentary volunteers 55) were...
Cardiovascular diseases (CVDs) are the leading cause of death among elderly people. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important regulator cholesterol metabolism. Herein, we investigated role PCSK9 in age-related CVD. Both humans and rats, blood level correlated positively with increasing age development cardiovascular dysfunction. Age-related fatty degeneration liver tissue serum levels rat model, while nonalcoholic disease functional impairment. Network analysis...
Conventional echocardiographic parameters such as tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and free-wall longitudinal strain (FWLS) offer limited insights into the complexity of right ventricular (RV) function, while 3D echocardiography-derived RV ejection fraction (RVEF) enables a comprehensive assessment. We investigated discordance between TAPSE, FAC, FWLS, RVEF in function grading associated outcomes.
Both heart failure with preserved ejection fraction (HFpEF) and non-alcoholic fatty liver disease (NAFLD) develop due to metabolic dysregulation, has similar risk factors (e.g., insulin resistance, systemic inflammation) are unresolved clinical challenges. Therefore, the potential link between two is important study. We aimed evaluate whether NASH an independent factor of cardiac dysfunction investigate age dependent effects on function. C57Bl/6 J middle aged (10 months old) mice (24 were...
Genetically determined left ventricular excessive trabeculation (LVET) has a wide clinical spectrum ranging from asymptomatic subjects to severe heart failure with arrhythmias and thromboembolic events. Unlike other cardiomyopathies, the relatives of LVET patients never reach spotlight guidelines practice, although these family members can be often affected by conditions. Thus, we aimed investigate multidimensional analysis, such as genetic testing, ECG cardiac ultrasound (ECHO). We included...
Abstract It is well known that left ventricular (LV) performance substantially influenced by the corresponding loading conditions and LV synchrony. Notably, data are scarce about interaction of these factors: previous studies suggest patients with bundle branch block (LBBB) has increased afterload sensitivity. This phenomenon may have special importance in certain clinical situations, such as aortic stenosis (AS) concomitant right pacing (RVP). Accordingly, our aim was to investigate effects...
Abstract Background/Introduction Accurate assessment of left ventricular (LV) and right (RV) systolic function is crucial in managing people with congenital heart disease (CHD), but can be challenging given the vast anatomic heterogeneity varied surgical history this population. While 3D echocardiography (3DE) most reproducible best-validated echocardiographic technique for assessing biventricular function, it requires special equipment expertise not feasible patients poor acoustic windows....
Abstract Background The pressure-strain loop is a non-invasive alternative to the traditional pressure-volume analysis for calculating myocardial work. Incorporating volume into work calculations may be particularly beneficial in evaluating patients with tricuspid regurgitation (TR) undergoing transcatheter valve intervention (TTVI), who often present highly varied load conditions. Purpose study aimed test hypothesis that pressure-strain-volume analysis-derived right ventricular (RV) will...
Abstract Background Diastolic dysfunction (DD) often precedes symptomatic heart failure and is a predictor of adverse outcomes; thus, accurate assessment grading are crucial for early interventions. Current guidelines recommend combining multiple echocardiographic parameters, including left atrial volume index (LAVi), diagnosing DD in patients with normal ventricular ejection fraction (LVEF). Recently, reservoir strain (LASr) emerged as more sensitive marker function, although its added...
Abstract Background With increasing life expectancy and aging of the population, aortic valve stenosis (AS) is now most prevalent valvular disease in developed nations. Left ventricular (LV) functional assessment challenging this pressure-overloaded state, however, myocardial work analysis may overcome issue by proving load-adjusted measures LV function. Notably, long-standing severe AS results progressive damage heart, starting from left remodeling to significant backward effects eventually...
Abstract In patients with aortic stenosis (AS) evaluating left ventricular (LV) systolic function is challenging due to the influence of increased afterload on traditional measures. Myocardial work (MW) analysis, a novel echocardiographic method, adjusts myocardial deformation instantaneous LV pressure, providing more accurate reflection contractile state. Notably, prolonged pressure overload induces significant backward effects beyond LV; classification this extravalvular cardiac damage...
Abstract Intense physical activity poses marked hemodynamic strain on the right ventricle (RV), as during exercise, RV is subjected to a proportionally higher pressure and volume overload than its left counterpart. While morphological changes of can be characterized using pre-defined reference shapes (cone sphere), complex structure cannot captured similarly. Therefore, exercise-induced in RV's global regional shape have not been directly investigated. Our aim was develop 3D echocardiography...
Body composition and cardiopulmonary exercise testing (CPET) are vital for optimizing sports performance, but the correlations between them still underexplored. Our study aimed to investigate relationships body specific CPET variables describing physical fitness in young athletes, also adjusting age height, a less-studied, female population. Seventy players participated our (age: 16.10 ± 1.63 y). After determining using dual-energy X-ray absorptiometry, we conducted treadmill-based...