A5028739124- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Aortic Disease and Treatment Approaches
- Cardiovascular Health and Disease Prevention
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Syncope and Autonomic Disorders
- Hemodynamic Monitoring and Therapy
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Cardiomyopathy and Myosin Studies
- Elasticity and Material Modeling
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced MRI Techniques and Applications
- Heart Failure Treatment and Management
- Advanced Neuroimaging Techniques and Applications
Guy's and St Thomas' NHS Foundation Trust
2021-2025
Harefield Hospital
2022-2025
Royal Brompton & Harefield NHS Foundation Trust
2018-2025
Imperial College London
2023-2025
AstraZeneca (United Kingdom)
2025
Royal Brompton Hospital
2018-2024
Semmelweis University
2023-2024
IRCCS Istituto Auxologico Italiano
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
University of Ulster
2023
RT-PCR tests to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA are the operational gold standard for detecting COVID-19 disease in clinical practice. assays UK have analytical sensitivity and specificity of greater than 95%, but no single assay exists.1Watson J Whiting PF Brush JE Interpreting a covid-19 test result.BMJ. 2020; 369m1808Crossref PubMed Scopus (519) Google Scholar, 2Mayers C Baker K Impact false-positives false-negatives UK's testing...
Comprehensive echocardiography assessment of right ventricular (RV) impairment has not been reported in critically ill patients with COVID-19. We detail the specific phenotype and clinical associations RV COVID-19 acute respiratory distress syndrome (ARDS).Transthoracic (TTE) measures function were collected unwell for clinical, ventilatory laboratory data.Ninety (25.6% female), mean age 52.0 ± 10.8 years, veno-venous extracorporeal membrane oxygenation (VVECMO) (42.2%) studied. A...
Abstract Aims Transthoracic 3D echocardiography (3DE) has been shown to be feasible and accurate measure right ventricular (RV) ejection fraction (EF) when compared with cardiac magnetic resonance (CMR). However, RV EF, either measured CMR or 3DE, always reported as normal (RV EF > 45%) abnormal ≤ 45%). We therefore sought identify the partition values of stratify dysfunction in mildly, moderately, severely reduced we are used do left ventricle. Methods results 3DE 412 consecutive...
The functional adaptation of the right ventricle (RV) to different degrees left ventricular (LV) dysfunction remains be clarified. We sought (1) assess changes in RV contraction pattern associated with reduction LV ejection fraction (EF) and (2) analyze whether assessment longitudinal, radial, anteroposterior motion components total RVEF adds prognostic value.Consecutive patients left-sided heart disease who underwent clinically indicated transthoracic echocardiography were enrolled a...
Abstract Background/Introduction Accurate assessment of left ventricular (LV) and right (RV) systolic function is crucial in managing people with congenital heart disease (CHD), but can be challenging given the vast anatomic heterogeneity varied surgical history this population. While 3D echocardiography (3DE) most reproducible best-validated echocardiographic technique for assessing biventricular function, it requires special equipment expertise not feasible patients poor acoustic windows....
Abstract Background 2D echocardiography requires multiple views for the assessment of left ventricular (LV) systolic function and does not enable calculation right (RV) ejection fraction (EF). 3D (3DE) has clear incremental value over echocardiography; nevertheless, its availability feasibility is limited. Purpose We aimed to develop a dual-task deep learning model – EF2Net predicting 3DE-derived LVEF RVEF from apical 4-chamber (A4C) view echocardiographic videos. Methods The comprises two...
Abstract Background Operational feasibility and reproducibility of echocardiographic (Echo) parameters are essential for planning interventional trials with surrogate imaging endpoints. Existing data from large cohort studies performed at institutions high expertise in Echo may not be representative the multicentre clinical trial settings where substantial variability local standards equipment exists. Purpose To assess standardized acquisition, measurability, key endpoints a trial. Methods...
Congenital heart disease (CHD) is the most common inborn defect affecting up to 1% of newborns. The prevalence CHD has shifted from childhood adulthood, and number adult patients living with continues increase. This patient population presents unique challenges in diagnostic imaging management due complex underlying cardiac morphology, previous operations interventions, hemodynamic conditions. Three-dimensional echocardiography (3DE) significantly improved our understanding anatomic...
Abstract Our aim was to assess the regional right ventricular (RV) shape changes in pressure and volume overload conditions their relations with RV function mechanics. The end-diastolic end-systolic endocardial surfaces were analyzed three-dimensional echocardiography (3DE) 33 patients (rToF), 31 (PH), 60 controls. mean curvature of inflow (RVIT) outflow (RVOT) tracts, apex body (both divided into free wall (FW) septum) measured. Zero defined a flat surface, whereas positive or negative...
The Purified Protein Derivative tuberculin skin tests (TST) and blood-based Mycobacterium tuberculosis (M . tb) specific interferon-gamma release assays (IGRA) are the currently used for identifying individuals with TB infection preventive treatment. However, challenges around access implementation have limited their use. Novel M tb (TBST) such as Diaskintest, ESAT6-CFP10 (C-TST), C-Tb (also known Cy-Tb), DPPD may provide accurate scalable options but evidence synthesis on economic impact is...
Syncope may develop in 9-35% of patients with pulmonary embolism (PE). Despite its severity and importance, the prognostic value syncope PE is unclear. We aimed to assess high-to-intermediate risk PE.A total 117 (62 males 55 females, median age 51,86 ± 13,4 years) were enrolled into study. According presence at onset PE, all divided two groups: group (SG) comprised 35 (48.8 15.5 years, male 54.3%) who experienced least one syncopal episode. The remaining 82 (53.4 12.6 42.7%) without control...