A5021393151- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Antimicrobial Resistance in Staphylococcus
- Escherichia coli research studies
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Genetics, Bioinformatics, and Biomedical Research
- Immune responses and vaccinations
- Extracellular vesicles in disease
- Biosensors and Analytical Detection
- Biochemical and Molecular Research
- Monoclonal and Polyclonal Antibodies Research
- Advanced Chemical Sensor Technologies
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Biomedical Text Mining and Ontologies
- Bacterial Identification and Susceptibility Testing
Imperial College London
2016-2025
University of Lübeck
2020-2024
Research Center Borstel - Leibniz Lung Center
2020-2024
German Center for Infection Research
2020-2024
Samara Regional Clinical Oncology Center
2014-2021
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
2018
Samara Medical Institute Reaviz
2011-2015
Samara Law Institute of the Federal Penitentiary Service of Russia
2011
Extensively drug-resistant (XDR) tuberculosis (TB), which is resistant to both first- and second-line antibiotics, an escalating problem, particularly in the Russian Federation. Molecular fingerprinting of 2348 Mycobacterium isolates collected Samara Oblast, Russia, revealed that 72% belonged Beijing lineage, a genotype associated with enhanced acquisition drug resistance increased virulence. Whole-genome sequencing 34 Samaran isolates, plus 25 representing global M. complex diversity,...
Abstract New tuberculosis treatments are needed to address drug resistance, lengthy treatment duration and adverse reactions of available agents. GSK3036656 (ganfeborole) is a first-in-class benzoxaborole inhibiting the Mycobacterium leucyl-tRNA synthetase. Here, in this phase 2a, single-center, open-label, randomized trial, we assessed early bactericidal activity (primary objective) safety pharmacokinetics (secondary objectives) ganfeborole participants with untreated,...
ABSTRACT Mycobacterium tuberculosis Beijing strains represent targets of special importance for molecular surveillance (TB), especially because they are associated with spread multidrug resistance in some world regions. Standard 24-locus mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) typing lacks resolution power accurately discriminating closely related clones that often compose strain populations. Therefore, we evaluated a set 7 additional,...
The World Health Organization recommends standardised treatment durations for patients with tuberculosis (TB). We identified and validated a host-RNA signature as biomarker individualised therapy drug-susceptible (DS)- multidrug-resistant (MDR)-TB.Adult pulmonary TB were prospectively enrolled into five independent cohorts in Germany Romania. Clinical microbiological data whole blood RNA transcriptomic analysis collected at pre-defined time points throughout therapy. Treatment outcomes...
ABSTRACT The rate of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has been steadily increasing in countries the former USSR. availability rapid reliable methods for detection drug resistance to second-line drugs is vital adequate patient management. We evaluated performance Genotype MTBDR sl assay compared that phenotypic susceptibility testing (Becton Dickinson Bactec MGIT 960 system) with a test panel 200 Mycobacterium isolates at four sites Eastern...
Tuberculosis (TB) is a major cause of mortality worldwide. Children and people living with HIV (PLHIV) have an increased risk mortality, particularly in the absence rapid diagnosis. The main challenges diagnosing TB these populations are due to unspecific paucibacillary disease presentation difficulty obtaining respiratory samples. Thus, novel diagnostic strategies, based on non-respiratory specimens could improve clinical decision making outcomes high burden settings. We propose...
The Purified Protein Derivative tuberculin skin tests (TST) and blood-based Mycobacterium tuberculosis (M . tb) specific interferon-gamma release assays (IGRA) are the currently used for identifying individuals with TB infection preventive treatment. However, challenges around access implementation have limited their use. Novel M tb (TBST) such as Diaskintest, ESAT6-CFP10 (C-TST), C-Tb (also known Cy-Tb), DPPD may provide accurate scalable options but evidence synthesis on economic impact is...
Objective and Methods A long-term observational study was conducted in Samara, Russia to assess the survival risk factors for death of a cohort non-multidrug resistant tuberculosis (non-MDRTB) multidrug (MDRTB) civilian prison patients extensive drug-resistant (XDRTB) cohort. Results MDRTB XDRTB rates 54.8% 11.1% were identified region. Half (50%) majority non-MDRTB (71%) still alive at 5 years. Over half (58%) died within two years establishing diagnosis XDRTB. In multivariate analysis,...
Abstract Background Recently, face mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use FMS to detect pulmonary children. We developed a method for M. tuberculosis-specific children and performed clinical exploration assess feasibility Methods Face masks were spiked, analyzed on GeneXpert-Ultra, quantitative polymerase chain reaction, targeted next-generation sequencing. Children...
The Russian Federation is a high-tuberculosis (TB)-burden country with high rates of drug resistance, including multidrug and extensive resistance to TB (M/XDRTB). Rapid diagnosis fluoroquinolones (FQs) using molecular assays essential for the implementation appropriate regimens prevention transmission XDR strains. A total 51 individual MDRTB strains were tested by pyrosequencing quinolone determining region gyrA gene GenoType MTBDRsl assay (Hain Lifescience, GmbH, Nehren, Germany), results...
The Russian Federation is a high-tuberculosis (TB)-burden country with high rates of Mycobacterium tuberculosis multidrug resistance (MDR) and extensive drug (XDR), especially in HIV-coinfected patients. Rapid reliable diagnosis for detection to second-line drugs vital adequate patient management. We evaluated the performance GenoType MTBDRsl (Hain Lifescience GmbH, Nehren, Germany) assay on smear-positive sputum specimens obtained from 90 HIV-infected MDR TB patients Russia. Test...