A5101940648- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Blood Pressure and Hypertension Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Renin-Angiotensin System Studies
- Gut microbiota and health
- Healthcare Systems and Public Health
- Infectious Diseases and Tuberculosis
- Renal Diseases and Glomerulopathies
- Cancer Diagnosis and Treatment
- Renal and Vascular Pathologies
- Organ Transplantation Techniques and Outcomes
- Hemophilia Treatment and Research
- Dental Trauma and Treatments
- Arsenic contamination and mitigation
- Potassium and Related Disorders
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Male Reproductive Health Studies
- Salivary Gland Disorders and Functions
- Vitamin K Research Studies
Institutul de Pneumoftiziologie "Marius Nasta"
2015-2025
Hôpital Sainte-Marguerite
2025
Grigore T. Popa University of Medicine and Pharmacy
2019-2024
Spitalul Clinic Dr. C. I. Parhon
2020-2024
University of Calgary
2023
University of Cincinnati
2023
Spitalul Clinic Judetean de Urgenta Sibiu
2023
Clinica de Pneumologie Iaşi
2011
The World Health Organization recommends standardised treatment durations for patients with tuberculosis (TB). We identified and validated a host-RNA signature as biomarker individualised therapy drug-susceptible (DS)- multidrug-resistant (MDR)-TB.Adult pulmonary TB were prospectively enrolled into five independent cohorts in Germany Romania. Clinical microbiological data whole blood RNA transcriptomic analysis collected at pre-defined time points throughout therapy. Treatment outcomes...
Treatment monitoring of tuberculosis patients is complicated by a slow growth rate Mycobacterium tuberculosis. Recently, host RNA signatures have been used to monitor the response treatment. Identifying and validating whole blood-based signature model predict microbiological treatment responses in on therapy. Using multi-step machine learning algorithm identify an RNA-based remaining time culture conversion at flexible points during anti-tuberculosis The identification cohort included 149...
Aims The aim of this study was to assess the necessity revising acetabular component in revision total hip arthroplasty (THA) patients with a Vancouver type B2 periprosthetic femoral fracture (PFF) who require component. hypothesis that both and components using dual-mobility would provide lower postoperative risk dislocation, without increasing perioperative morbidity mortality. Methods Data were retrospectively analyzed from continuously gathered database. We included 150 revisions,...
Background: Neuropathic adverse events occur frequently in linezolid-containing regimens, some of which remain irreversible after drug discontinuation. Objective: We aimed to identify and validate a host RNA-based biomarker that can predict linezolid-associated neuropathy before multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment initiation genes pathways are associated with neuropathy. Methods: Adult patients initiating MDR/RR-TB including linezolid were...
Multidrug-resistant tuberculosis (MDR-TB) is a major burden to public health in Europe. Reported treatment success rates are around 50% or less, and cure even lower.To document the management outcome patients with MDR-TB Europe.We performed prospective cohort study, analyzing outcomes stratified by incidence of Treatment were compared World Health Organization alternative simplified definitions Tuberculosis Network European Trialsgroup (TBNET).A total 380 recruited followed up between 2010...
The study aimed to present the characteristics of three most prevalent oral potentially malignant disorders, leukoplakia, lichen planus (OLP), and actinic cheilitis, using data from 62 patients collected at “Sfântul Spiridon” Emergency Clinical Hospital in Iași, Romania, between January 2015 2023. results revealed a higher prevalence these lesions among older adults, particularly those over 50 years old, significant gender disparity incidence which was more common males (68%). Leukoplakia...
In general terms, neoplastic conditions are characterized by increasing in cell proliferation and decreasing apoptosis. The multiplication of atypical cells, through their invasive capacity, leads to the infiltration tissues or organs bloodstream lymphatic system. this context, chemotherapy remains one most used treatment modalities, contrary progress made recent years regarding management cancer Oro-Maxillo-Facial (OMF) sphere. This is applied either alone associated with other therapeutic...
Menopause is a non-pathological change which involve the permanent cessation of menstruation for at least 12 months and occurs in women with an average age 51 years context estrogen deficiency. The effects menopause are closely related to lack ovarian hormones, fact that induces physical emotional instability woman direct impact on health oral cavity. This paper reviews changes mucosa peri- post-menopause phases. most frequently reported are: dryness cavity, sensation decreased amount...
Journal Article Accepted manuscript Can amino acid interventions prevent acute kidney injury in cardiac surgery? A meta-analysis and systematic review Get access Adrian Covic, Covic Faculty of Medicine, University Medicine Pharmacy "Grigore T Popa," Iasi, RomaniaNephrology Clinic, Dialysis, Renal Transplant Center -"C.I. Parhon" Hospital, Romania Search for other works by this author on: Oxford Academic PubMed Google Scholar Grigore Tinica, Tinica RomaniaInstitute Cardiovascular Diseases...
Abstract Background Tuberculosis (TB) remains a global health challenge, with 1.3 million deaths in 2022. Ten countries the European Union (EU) and Economic Area (EEA) accounted for 88.3% of TB cases, which 23.8% were from Romania. Evidence shows that mental issues, decreased quality life negative socio-economic impact are common among patients; however, there is limited evidence available The main aim this study to longitudinally assess life, health, status patients drug-resistant (DR TB)...