A5015993779- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Antibiotics Pharmacokinetics and Efficacy
- Diagnosis and treatment of tuberculosis
- Healthcare cost, quality, practices
- Cell Image Analysis Techniques
- Antimicrobial Resistance in Staphylococcus
- Cytomegalovirus and herpesvirus research
- Orthopedic Infections and Treatments
- Antibiotic Resistance in Bacteria
- Image Processing Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Traditional Chinese Medicine Studies
- Cancer therapeutics and mechanisms
German Center for Infection Research
2023-2025
Research Center Borstel - Leibniz Lung Center
2023-2025
University of Lübeck
2023-2025
University Medical Center Hamburg-Eppendorf
2024-2025
Universität Hamburg
2024-2025
Kohler (New Zealand)
2024
Treatment monitoring of tuberculosis patients is complicated by a slow growth rate Mycobacterium tuberculosis. Recently, host RNA signatures have been used to monitor the response treatment. Identifying and validating whole blood-based signature model predict microbiological treatment responses in on therapy. Using multi-step machine learning algorithm identify an RNA-based remaining time culture conversion at flexible points during anti-tuberculosis The identification cohort included 149...
Background: Neuropathic adverse events occur frequently in linezolid-containing regimens, some of which remain irreversible after drug discontinuation. Objective: We aimed to identify and validate a host RNA-based biomarker that can predict linezolid-associated neuropathy before multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment initiation genes pathways are associated with neuropathy. Methods: Adult patients initiating MDR/RR-TB including linezolid were...
The treatment of drug-resistant Mycobacterium tuberculosis relies on complex antibiotic therapy. Inadequate exposure can lead to failure, acquired drug resistance, and an increased risk adverse events. Therapeutic monitoring (TDM) be used optimize the exposure. Therefore, we aimed develop a single-run multiplex assay using high-performance liquid chromatography-mass spectrometry (HPLC-MS) for TDM patients with multidrug-resistant, pre-extensively extensively tuberculosis. A target profile...
To investigate the safety profiles and clinical outcomes in a continuous cohort of tuberculosis (TB) patients from referral centre Germany receiving self-administered outpatient parenteral antimicrobial therapy (sOPAT).
Tuberculosis (TB) is a major global health threat and demands improved diagnostic treatment monitoring methods. Conventional diagnostics, such as sputum smear microscopy culture, are limited by slow results low sensitivity, particularly in certain patient groups. Recent advances biomarker research offer promising solutions three key areas: risk of disease, diagnosis active disease response. For assessment, novel genetic signatures metabolites show potential predicting the progression from TB...