A5063773538- Antibiotics Pharmacokinetics and Efficacy
- Diet and metabolism studies
- Analytical Methods in Pharmaceuticals
- Schizophrenia research and treatment
- Pharmacogenetics and Drug Metabolism
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects and Toxicity Studies
- Cancer therapeutics and mechanisms
- COVID-19 and healthcare impacts
- Tuberculosis Research and Epidemiology
- Bipolar Disorder and Treatment
- Epilepsy research and treatment
- HIV Research and Treatment
- Ion channel regulation and function
- Chronic Lymphocytic Leukemia Research
- Muscle metabolism and nutrition
- Regulation of Appetite and Obesity
- Hormonal and reproductive studies
- Inhalation and Respiratory Drug Delivery
- Metabolism, Diabetes, and Cancer
- Bacterial Identification and Susceptibility Testing
- Cholinesterase and Neurodegenerative Diseases
- Cancer Treatment and Pharmacology
- Pesticide Residue Analysis and Safety
University Hospital of Lausanne
2012-2025
University of Lausanne
2012-2024
University Hospital of Basel
2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2022
NIHR Birmingham Biomedical Research Centre
2021
University of Birmingham
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
University of Geneva
2017
The long-acting antiretroviral cabotegravir and rilpivirine combination has just received FDA, EMA Health Canada approval. This novel drug delivery approach is about to revolutionize the therapy of people living with HIV, decreasing 365 daily pill burden only six intramuscular injections per year. In addition, islatravir, a first-in-class nucleoside reverse transcriptase translocation inhibitor, intended be formulated as an implant dosing interval 1 year or more. At present, therapies...
The efficacy and tolerability of long-acting cabotegravir rilpivirine were demonstrated in Phase III trials. However, low concentrations combined with other risk factors have been associated an increased virologic failure. This study aims to verify whether drug measured a real-world setting are consistent those previously reported.
Article Abstract Background: Psychotropic drugs can induce substantial weight gain, particularly during the first 6 months of treatment. The authors aimed to determine potential predictive power an early gain after introduction gain-inducing psychotropic on long-term gain. Method: Data were obtained from a 1-year longitudinal study ongoing since 2007 including 351 psychiatric (ICD-10) patients, with metabolic parameters monitored (baseline and/or 1, 3, 6, 9, 12 months) and compliance...
Unpredictable pharmacokinetics of antibiotics in patients with life-threatening bacterial infections is associated drug under- or overdosing. Therapeutic monitoring (TDM) may guide dosing adjustment aimed at maximizing antibacterial efficacy and minimizing toxicity. Rapid accurate analytical methods are key for real-time TDM. Our objective was to develop a robust high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS) multiplex quantification plasma concentrations...
Janus kinase inhibitors (JAKi) are oral small molecules used in the treatment of a broad spectrum autoimmune and myeloproliferative diseases. JAKi exhibit significant intra- inter-individual pharmacokinetic variabilities, due to fluctuations compliance with treatments their metabolism essentially driven by cytochrome P450 enzymes. Intrinsically, have dose-response relationship narrow therapeutic index: drug monitoring (TDM) is expected optimize adapt dosage regimen order resolve problems...
Cystic fibrosis (CF) is a life-threatening disorder caused by mutations in the CFTR gene, leading to defective chloride ion transport and thickened mucus respiratory gastrointestinal systems. modulators, including ivacaftor, lumacaftor, tezacaftor, elexacaftor, have improved patient outcomes, but interindividual pharmacokinetic variability potential drug-drug interactions require therapeutic drug monitoring (TDM) for optimal efficacy safety. In this context, liquid chromatography-tandem mass...
Abstract Women recover faster from propofol anaesthesia and have been described to a higher incidence of awareness during surgery, compared men – an effect that may be inherent in sex differences metabolism. In observational study, 98 ASA I‐ II patients treated with continuous infusion were recruited. The associations between CYP2B6 UGT1A9 polymorphisms dose‐ weight‐adjusted area under the total plasma level time curves ( AUC ) for propofol, its metabolites glucuronide PG ),...
Abstract The widespread use of highly active antiretroviral treatments has dramatically changed the prognosis people living with HIV (PLWH). However, such have to be taken lifelong raising issues regarding maintenance both therapeutic effectiveness and long‐term tolerability. Recently approved or investigational drugs present considerable advantages, allowing once daily oral dosage along activity against resistant variants (eg, bictegravir doravirine) also parenteral intramuscular...
IMPORTANCEThere is a high prevalence of obesity in psychiatric patients, possibly leading to metabolic complications and reducing life expectancy.The CREB-regulated transcription coactivator 1 (CRTC1) gene involved energy balance animal models, but its role human unknown.OBJECTIVE To determine whether polymorphisms within the CRTC1 are associated with adiposity markers patients general population.DESIGN, SETTING, AND PARTICIPANTS Retrospective prospective data analysis population-based...
Background (S)-Methadone, metabolized mainly by CYP2B6, shows a wide interindividual variability in its pharmacokinetics and pharmacodynamics. Methods Resequencing of the CYP2B6 gene was performed 12 35 selected individuals with high (S)-methadone plasma exposure low exposure, respectively, from previously described cohort 276 patients undergoing methadone maintenance treatment. Selected genetic polymorphisms were then analyzed complete cohort. Results The rs35303484 (*11; c136A>G; M46V)...
Busulfan (Bu) is an alkylating agent used as part of the conditioning regimen in pediatric patients before hematopoietic stem cell transplantation. Despite intravenous (IV) administration and dosing recommendations based on age weight, reports have revealed interindividual variability Bu pharmacokinetics outcomes In this context, adjusting doses to Bu's narrow therapeutic window advised. We aimed assess utility drug monitoring (TDM) children, reliability quantification methods, its stability...
Long‐acting cabotegravir has been studied mainly in the stringent framework of clinical trials, which does not necessarily reflect situation people with HIV (PWH) routine settings. The present population pharmacokinetic analysis aims to build real‐world reference percentile curves concentrations, accounting for patient‐related factors that may affect exposure. second objective is simulate whether dosing interval adjustments could be considered specific subpopulations. Overall, 238 PWH...
Risperidone is metabolized by polymorphic enzymes, and a large variability in plasma concentration therapeutic response observed. long-acting injection (RLAI) avoids the first-pass effect, little known about influence of gene polymorphisms involved its pharmacokinetics. The on concentrations risperidone (RIS), metabolite 9-hydroxy-risperidone, adverse effects were investigated for cytochrome P450 2D6 (CYP2D6) (*3, *4, *5, *6), CYP3A (CYP3A4*1B, CYP3A4 rs4646437, CYP3A5*3, CYP3A7*1C), ABCB1...
Cytochrome P450 2W1 (CYP2W1) is expressed predominantly in colorectal and also hepatic tumors, whereas the levels are insignificant corresponding normal human adult tissues. CYP2W1 has been proposed as an attractive target for cancer (CRC) therapy by exploiting its ability to activate duocarmycin prodrugs cytotoxic metabolites. However, endogenous function, regulation developmental pattern of expression remain unexplored. Here we report murine gastrointestinal The gene colon small intestine...