A5037650928- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Chemokine receptors and signaling
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Atherosclerosis and Cardiovascular Diseases
- Atomic and Subatomic Physics Research
- Allergic Rhinitis and Sensitization
- Pharmaceutical studies and practices
- Advanced MRI Techniques and Applications
- Parasites and Host Interactions
- Bacteriophages and microbial interactions
- Respiratory and Cough-Related Research
- Bone health and treatments
- Nematode management and characterization studies
- Child Nutrition and Water Access
- Respiratory viral infections research
- T-cell and B-cell Immunology
- Contact Dermatitis and Allergies
- Immunodeficiency and Autoimmune Disorders
- Immune responses and vaccinations
University of Lausanne
1992-2024
Hospital Neuchâtel
2019-2024
University of Zurich
2023
University Children's Hospital Zurich
2023
University Hospital of Geneva
1997-2023
University of St. Gallen
2023
University Hospital of Lausanne
1996-2022
Hôpital de Morges
2012-2017
Hôpital Orthopédique de la Suisse Romande
2002-2005
Massachusetts General Hospital
1998-2001
Activated T lymphocytes accumulate early in atheroma formation and persist at sites of lesion growth rupture, suggesting that they may play an important role the pathogenesis atherosclerosis. Moreover, atherosclerotic lesions contain Th1-type cytokine IFN-γ, a potentiator The present study demonstrates differential expression 3 IFN-γ–inducible CXC chemokines — IFN-inducible protein 10 (IP-10), monokine induced by IFN-γ (Mig), T-cell α chemoattractant (I-TAC) atheroma-associated cells, as...
Abstract Recruitment of activated T cells to mucosal surfaces, such as the airway epithelium, is important in host defense and for development inflammatory diseases at these sites. We therefore asked whether CXC chemokines IFN-induced protein 10 kDa (IP-10), monokine induced by IFN-γ (Mig), IFN-inducible T-cell α-chemoattractant (I-TAC), which specifically chemoattract signaling through chemokine receptor CXCR3, were inducible respiratory epithelial cells. The effects proinflammatory...
Abstract —Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. However, their role in modulating platelet function has not been shown. We studied effect chemokines on human platelets found 16 tested only stromal cell–derived factor (SDF)-1 induced aggregation, accompanied by a rise intracellular calcium. Platelets expressed SDF-1 receptor, CXCR4, an antibody to CXCR4 pertussis toxin inhibited SDF-1–induced confirming this is mediated through Gαi-coupled...
Peroxisome proliferator-activated receptor-gamma (PPARgamma), a member of the nuclear hormone receptor superfamily originally shown to play an important role in adipocyte differentiation and glucose homeostasis, is now known regulate inflammatory responses. Given importance endothelial cell (EC)-derived chemokines regulating leukocyte function trafficking, we studied effects PPARgamma ligands on expression induced ECs by Th1 cytokine IFN-gamma. Treatment with activators significantly...
Allergic asthma is an inflammatory disease of the airways characterized by eosinophilic inflammation and airway hyper-reactivity. Cytokines chemokines specific for Th2-type predominate in animal models this disease. The role Th1-type mediators remains controversial. IFN-gamma-inducible protein 10 (IP-10; CXCL10) chemokine that preferentially attracts activated Th1 lymphocytes. IP-10 up-regulated asthmatics, but its function unclear. To investigate allergic disease, we examined expression a...
To investigate whether respiratory acidosis modulates ventilator-induced lung injury (VILI), we perfused (constant flow) 21 isolated sets of normal rabbit lungs, ventilated them for 20 min (pressure controlled ventilation [PCV] = 15 cm H2O) (Baseline) with an inspired CO2 fraction adjusted the partial pressure in perfusate (Pco 2 ≅ 40 mm Hg), and then randomized into three groups. Group A (control: n 7) was PCV H2O consecutive 20-min periods (T1, T2, T3). In B (high / normocapnia; 7), given...
The movement of leukocytes into tissues is regulated by the local production chemical mediators collectively referred to as chemoattractants. Although chemoattractants constitute a diverse array molecules, including proteins, peptides, and lipids, they all appear signal through related family seven transmembrane–spanning G protein–coupled receptors. eosinophil potent proinflammatory cell that attracted during allergic inflammation, parasitic infection, certain malignancies. Since molecular...
Abstract Chemokine receptors are rapidly desensitized and internalized following ligand binding, a process that attenuates receptor-mediated responses. However, the physiological settings in which this occurs not clear. Therefore, we examined fate of CXCR3, chemokine receptor preferentially expressed on activated T cells contact with endothelial cells. By immunofluorescence microscopy flow cytometry, found CXCR3 was when were incubated IFN-γ-activated human saphenous vein (HSVEC), but...
The Global Initiative for Asthma (GINA) is a network of individuals, organizations, and public health officials that was established to disseminate information about the care patients with asthma improve care. GINA ("Global Strategy Management Prevention") report has been updated annually since 2002. Due new knowledge therapeutic development in field, Swiss Respiratory Society felt need provide document based on both available literature recommendations 2016 report. Key features include...
Interstitial lung disease (ILD) is a complication of polymyositis (PM) and dermatomyositis (DM). It often manifests itself in association with myositis-specific antisynthetase autoantibodies, among which anti-Jo-1 antibodies are the most commonly encountered. In contrast, ILD associated without muscle involvement rare not well characterized. We report four patients presenting antibodies. Histological findings transbronchial biopsies disclosed pattern consistent nonspecific interstitial...
Cystic fibrosis (CF) is a life-threatening disorder caused by mutations in the CFTR gene, leading to defective chloride ion transport and thickened mucus respiratory gastrointestinal systems. modulators, including ivacaftor, lumacaftor, tezacaftor, elexacaftor, have improved patient outcomes, but interindividual pharmacokinetic variability potential drug-drug interactions require therapeutic drug monitoring (TDM) for optimal efficacy safety. In this context, liquid chromatography-tandem mass...
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Arterialized ear lobe blood samples have been described as adequate to gauge gas exchange in acute and chronically ill patients. It is a safe procedure, usually performed by medical technicians. We conducted prospective study verify the validity of this method. One hundred fifteen consecutive adult patients were studied. Blood drawn simultaneously from arterialized earlobe radial artery. Values partial pressure oxygen (PO2) carbon dioxide (PCO2) measured means electrodes. The correlation...
Purpose Magnetic resonance imaging is a promising alternative to computed tomography for lung imaging. However, organ motion and poor signal‐to‐noise ratio, arising from short , impair image quality. To alleviate these issues, new retrospective gating method was implemented tested with an ultra‐short echo time sequence. Methods A 3D double‐echo sequence used acquire data during free breathing in ten healthy adult subjects. self‐gating reconstruct respiratory suppressed expiratory inspiratory...
Immune checkpoint inhibitors (ICIs) have been shown to improve overall and progression-free survival in various cancers but associated with immune-related adverse events (IRAEs), including interstitial lung disease, especially organizing pneumonia. We report 2 cases of isolated severe airway disease attributable ICIs, a rarely reported pattern toxicity. The first patient received nivolumab or without ipilimumab randomized double-blind trial for locoregional metastatic melanoma. second was...
Up to 60% of patients receiving their first infusion the bisphosphonate pamidronate experience an acute-phase reaction. In this study, we used flow cytometry determine effects treatment on circulating lymphocyte subpopulations, and investigated whether ibandronate affect subpopulations differently. Twenty received a infusion, 20 intravenously injected ibandronate, 10 controls clodronate infusion. Pamidronate was followed by significant increase in median body temperature at 10-hour...