A5075106853- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Cardiovascular and exercise physiology
- Obstructive Sleep Apnea Research
- Heart Rate Variability and Autonomic Control
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Protease and Inhibitor Mechanisms
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Health and Disease Prevention
- Peptidase Inhibition and Analysis
- Inhalation and Respiratory Drug Delivery
- Long-Term Effects of COVID-19
- Cystic Fibrosis Research Advances
- Cardiovascular and Diving-Related Complications
- Physical Activity and Health
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- COVID-19 and Mental Health
- Nursing Diagnosis and Documentation
- Nutrition and Health in Aging
- Tracheal and airway disorders
- Family and Patient Care in Intensive Care Units
- Pneumonia and Respiratory Infections
University Hospital of Zurich
2016-2025
University of Zurich
2005-2025
German Insurance Association
2025
Zürcher Fachhochschule
2022
University of Basel
2011
Kantonsspital Münsterlingen
2011
Swiss Integrative Center for Human Health
2007
Friedrich-Alexander-Universität Erlangen-Nürnberg
2002
Background The infectious coronavirus disease 2019 (COVID-19) pandemic is an ongoing global healthcare challenge. Up to one-third of hospitalised patients develop severe pulmonary complications and acute respiratory distress syndrome. Pulmonary outcomes following COVID-19 are unknown. Methods Swiss lung study a multicentre prospective cohort investigating sequelae COVID-19. We report on initial follow-up 4 months after mild/moderate or severe/critical according the World Health Organization...
Abstract A growing number of patients with SARS-CoV-2 infections experience long-lasting symptoms. Even who suffered from a mild acute infection show variety persisting and debilitating neurocognitive, respiratory, or cardiac symptoms (Long-Covid syndrome), consequently leading to limitations in everyday life. Because data on health-related quality life (HRQoL) is scarce, we aimed characterize the impact Long-Covid after moderate HRQoL. In this observational study, outpatients seeking...
Duchenne muscular dystrophy (DMD) leads to progressive, generalized paresis, and respiratory failure in the second decade of life. The assumption that severe physical disability precludes an acceptable quality life is common, but has not been specifically evaluated DMD.The purpose this study was investigate relation disability, pulmonary function, need for assisted ventilation DMD.In 35 patients with DMD, aged 8-33 yr, we assessed by a score ranging from 9 (no disability) 80 (complete...
<h3>Background:</h3> Duchenne muscular dystrophy (DMD) leads to progressive impairment of muscle function, respiratory failure and premature death. Longitudinal data on the course physical disability function are sparse. <h3>Objectives:</h3> To assess prospectively disability, survival in patients with DMD over several years describe disease current care. <h3>Methods:</h3> In 43 DMD, aged 5–35 years, yearly assessments by Impairment Dependence care (DID) score, ranging from 9 (no disability)...
Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular mortality. Endothelial dysfunction may underpin this association. This cross-sectional study aimed to determine the impact of airflow obstruction, systemic inflammation, oxidative stress, sympathetic activation, hypoxaemia and physical activity on endothelial function in COPD. In stable COPD patients, assessments by flow-mediated dilatation (FMD), risk (Pocock score), obstruction (forced expiratory...
Rationale: Intravenous plasma-purified alpha-1 antitrypsin (IV-AAT) has been used as therapy for deficiency (AATD) since 1987. Previous trials (RAPID and RAPID-OLE) demonstrated efficacy in preserving CT lung density but no effect on FEV1. This observational study evaluated 615 people with severe AATD from three countries socialized healthcare (Ireland, Switzerland, Austria), where access to standard medical care was equal IV-AAT not. Objectives: To assess the real-world longitudinal effects...
<b><i>Background:</i></b> The occurrence of both chronic obstructive pulmonary disease (COPD) and sleep apnea (OSA) in an individual patient has been described as ‘overlap syndrome', which associated with poor prognosis. Little is known about the possible predictors overlap syndrome its association comorbidities contributing to impaired outcome. <b><i>Objectives:</i></b> This study aimed evaluate prevalence a cohort COPD patients....
Objectively measuring daily physical activity (PA) using an accelerometer is a relatively expensive and time-consuming undertaking. In routine clinical practice it would be useful to estimate PA in patients with chronic obstructive pulmonary disease (COPD) more simple methods.To evaluate whether can estimated by tests commonly used COPD.The average number of steps per day was measured for 7 days SenseWear Pro™ as gold standard PA. A level (PAL) <1.4 considered very inactive. Univariate...
We described physical activity measures and hourly patterns in patients with chronic obstructive pulmonary disease (COPD) after stratification for generic COPD-specific characteristics and, based on multiple measures, we identified clusters of patients. In total, 1001 COPD (65% men; age, 67 years; forced expiratory volume the first second [FEV 1 ], 49% predicted) were studied cross-sectionally. Demographics, anthropometrics, lung function clinical data assessed. Daily analysed from a...
The Global Initiative for Asthma (GINA) is a network of individuals, organizations, and public health officials that was established to disseminate information about the care patients with asthma improve care. GINA ("Global Strategy Management Prevention") report has been updated annually since 2002. Due new knowledge therapeutic development in field, Swiss Respiratory Society felt need provide document based on both available literature recommendations 2016 report. Key features include...
<b><i>Introduction:</i></b> Emerging evidence suggests that long-term pulmonary symptoms and functional impairment occurs in a proportion of individuals following SARS-CoV-2 infection. Although the affected patients remains to be determined, physicians are increasingly being confronted with reporting respiratory beyond acute phase COVID-19. In face limited evidence, Swiss Society for Pulmonology established working group address this area unmet need formulated...
Abstract Background Alpha-1 antitrypsin deficiency (AATD) is a rare disease that associated with an increased risk of pulmonary emphysema. The European AATD Research Collaboration (EARCO) international registry was founded the objective characterising individuals and investigating their natural history. Methods EARCO international, observational prospective study AATD, defined as AAT serum levels < 11 μM and/or proteinase inhibitor genotypes PI*ZZ, PI*SZ compound heterozygotes or...
Previous studies with small sample sizes reported contradicting findings as to whether pulmonary function tests can predict exercise-induced oxygen desaturation (EID).To evaluate forced expiratory volume in one second (FEV(1)), resting saturation (SpO(2)) and diffusion capacity for carbon monoxide (DLCO) are predictors of EID chronic obstructive disease (COPD).We measured FEV(1), DLCO, SpO(2) at rest during a 6-min walking test well physical activity by an accelerometer. A drop >4 <90% was...
Abstract Background and objective Both comorbidities physical inactivity have been shown to impair quality of life contribute hospital admissions mortality in chronic obstructive pulmonary disease ( COPD ) patients. We hypothesized that the comorbid status predicts level daily activity PA . Methods In 228 patients with (76% men; median (quartiles) age: 64 (59/69) years; percentage predicted forced expiratory volume 1 s FEV % pred): 44 (31/63)), were assessed by medical history, clinical...
<h3>Background</h3> Sleep disturbances are common in patients with chronic obstructive pulmonary disease (COPD) a considerable negative impact on their quality of life. However, factors associated measures sleep daily life have not been investigated before nor has the association between and ability to engage physical activity day-to-day basis studied. <h3>Aims</h3> To provide insight into relationship actigraphic severity, exertional dyspnoea, gender parts week; investigate next day...
Resistance training of peripheral muscles has been recommended in order to increase muscle strength patients with Chronic Obstructive Pulmonary Disease (COPD). However, whether is associated exercise performance (EP) and physical activity daily life (PADL) these needs be investigated. The aim this study evaluate the quadriceps (QS) EP PADL COPD.We studied COPD (GOLD A-D) measured maximal isometric left QS. was for 7 days a SenseWear-Pro® accelerometer. quantified by 6-minute walk distance...
In Switzerland, while the quality of acute inpatient care for patients with AECOPD is high, a lack post-acute interventions has been identified. To correct this shortfall, an integrated program was initiated at University Hospital Zurich. The study's aim to compare defined intervention implementation rates before and after new program's implementation. A retrospective medical chart review performed regarding hospitalized due between July 2019 March 2023. control group (CG) had received usual...
ABSTRACT Objectives This study evaluated the impact of increased working from home on musculoskeletal pain before and after SARS-CoV-2 pandemic. Methods In an online survey (September 2023 to April 2024), was rated a numeric rating scale. The covariates new onset exacerbation modeled using logistic regression analyses. Results Of 1,064 participating computer workers, 968 were home. Working compared office-only work, showed trend increasing pain. Longer remote hours poorer workstation setups...
Background While the presence of distinct imaging abnormalities by high-resolution CT (HRCT) defines interstitial lung disease (ILD), there is a relative lack validated methods to quantify these in clinical practice, limiting ILD severity and progression assessments. We aimed validate semi-quantitative method for fibrosis assessment patients with systemic sclerosis associated (SSc-ILD) standard low-dose HRCT, considering structure function as integral components evaluation. Methods SSc from...
Solitary fibrous tumours of the pleura (SFTP) are rare and can histologically be differentiated into benign malignant forms. The aim this study is to present new cases, discuss up-to-date preoperative examinations, role video-assisted thoracic surgery long-term outcome.Between 1993 2006, 27 SFTPs were diagnosed (14 females, mean age+/-SD, 62.3+/-9.6 years) at our institution. Medical records reviewed, follow-up was obtained by repeated examinations or contact with general practitioners.SFTPs...