A5013756173- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Systemic Sclerosis and Related Diseases
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Malaria Research and Control
- Contact Dermatitis and Allergies
- Vasculitis and related conditions
- Pediatric health and respiratory diseases
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Health and Medical Studies
- Inflammatory Myopathies and Dermatomyositis
- Dermatologic Treatments and Research
- Drug-Induced Adverse Reactions
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Healthcare Systems and Practices
- Mosquito-borne diseases and control
University Hospital of Lausanne
2014-2024
University of Lausanne
2009-2024
Hôpital Orthopédique de la Suisse Romande
1983-2024
Oslo University Hospital
2022
Sheffield Teaching Hospitals NHS Foundation Trust
2021
Royal Hallamshire Hospital
2021
Zentrum für Rhinologie und Allergologie
2020
Hôpital de l'enfance
1993-2019
ENT and Allergy
1996-2018
National Alliance on Mental Illness
2014
<h3>Objectives</h3> Adult-onset Still's disease (AOSD) is a rare systemic autoinflammatory disease; its management largely empirical. This the first clinical study to determine if interleukin (IL)-18 inhibition, using recombinant human IL-18 binding protein, tadekinig alfa, therapeutic option in AOSD. <h3>Methods</h3> In this phase II, open-label study, patients were ≥18 years with active AOSD plus fever or C reactive protein (CRP) levels ≥10 mg/L despite treatment prednisone and/or...
We developed interferon-α-kinoid (IFN-K), a drug composed of inactivated IFNα coupled to carrier protein, keyhole limpet hemocyanin. In human IFNα-transgenic mice, IFN-K induces polyclonal antibodies that neutralize all 13 subtypes IFNα. also previously demonstrated slows disease progression in mouse model systemic lupus erythematosus (SLE). This study was undertaken examine the safety, immunogenicity, and biologic effects active immunization with patients SLE.We performed randomized,...
IL-18 is a pro-inflammatory cytokine of the IL-1 family that naturally inhibited by binding protein (IL-18BP). High levels have been described in serum adult-onset Still's disease (AOSD) patients, but only total (including inactive bound to IL-18BP) measured. With specific immunoassay, we aimed measure free AOSD patients and other rheumatic diseases.An ELISA was developed IL-18. Its sensitivity specificity were tested spiking recombinant or IL-18BP PBS supplemented with 5% BSA. The affinity...
Abstract MTBVAC is a live-attenuated Mycobacterium tuberculosis vaccine, currently under clinical development, that contains the major antigens ESAT6 and CFP10. These are absent from current BCG. Here we compare protection induced by BCG in several mouse strains naturally express different MHC haplotypes differentially recognizing induces improved C3H mice, only of three tested reactive to both Deletion reduces its efficacy levels, supporting link between greater CFP10- ESAT6-specific...
The generation of protective humoral immunity after vaccination relies on the productive interaction between antigen-specific B cells and T follicular helper (Tfh) cells. Despite central role Tfh in vaccine responses, there is currently no validated way to enhance their differentiation humans. From paired human lymph node blood samples, we identify a population circulating that are transcriptionally clonally similar germinal center In clinical trial formulations, were expanded Tanzanian...
Background Plasmodium falciparum merozoite surface protein 3 is a malaria vaccine candidate that was identified, characterised, and developed based on unique immuno-clinical approach. The construct derived from regions fully conserved among various strains containing B cell epitopes targeted by human antibodies (from malaria-immune adults) are able to mediate monocyte-dependent parasite killing effect. corresponding long synthetic peptide administered 36 volunteers, with either alum or...
The C-terminal conserved region of Plasmodium falciparum merozoite surface protein 3 (MSP3) is the trigger antigen a protective immune response mediated by cytophilic antibodies. In an open, randomized, two-adjuvant (Montanide ISA 720, aluminum hydroxide) phase I clinical trial we evaluated safety and immunogenicity increasing doses long synthetic peptide construct spanning MSP3 targeted biologically active antibodies (MSP3-LSP). Thirty-five healthy volunteers were randomized to receive...
Abstract Chemokine receptors are rapidly desensitized and internalized following ligand binding, a process that attenuates receptor-mediated responses. However, the physiological settings in which this occurs not clear. Therefore, we examined fate of CXCR3, chemokine receptor preferentially expressed on activated T cells contact with endothelial cells. By immunofluorescence microscopy flow cytometry, found CXCR3 was when were incubated IFN-γ-activated human saphenous vein (HSVEC), but...
Abstract In addition to being instrumental the protection of mucosal epithelia, secretory IgA (SIgA) adheres and is transported by intestinal Peyer’s patch (PP) M cells. The possible functional reason for this transport unknown. We have thus examined in mice outcome SIgA delivered from lumen cells present underlying organized mucosa-associated lymphoreticular tissue. show selective association with dendritic CD4+ T B lymphocytes recovered PP vitro. vivo, exogenously able enter into multiple...
MRL-lpr/lpr mice spontaneously develop a lupus-like syndrome characterized by immunopathological manifestations such as necrotizing vascular lesions of ear tips and severe glomerulonephritis. Similar skin glomerular associated with cryoglobulinemia can be induced in normal injection monoclonal antibody (mAb)--6-19 (gamma 3 heavy chain kappa light chain), exhibiting both cryoglobulin anti-IgG2a rheumatoid factor (RF) activities--derived from the autoimmune mouse. To determine role RF and/or...
A total of 20 23 IgG3 mAb derived from unmanipulated autoimmune MRL/MpJ-lpr/lpr mice was shown to generate cryoglobulins which were composed exclusively IgG3. Although three failed develop cryoglobulins, they able bind nonspecifically any molecules as efficiently cryoprecipitable IgG did. The direct role the gamma 3 constant region for generation demonstrated by following findings: 1) cryoglobulin activity independent specificity mAb, 2) no other than those subclass, including IgM rheumatoid...
Objective. IFN α Kinoid (IFN-K) is a therapeutic vaccine composed of IFNα2b coupled to carrier protein. In phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the gene signature in whole blood RNA samples from SLE patients. Here, analysed extended follow-up data IFN-K-treated patients, order evaluate persistence neutralizing anti-IFNα Abs antibodies (Abs), and expression profiling.
<h3>Background</h3> The prevalence of esophageal stenosis caused by immune checkpoint inhibitors in the context induced mucositis and esophagitis is extremely rare. <h3>Case presentation</h3> We report case a patient with stage IV pulmonary adenocarcinoma treated for 6 months nivolumab who developed bilateral sterile conjunctivitis followed oropharyngeal complicated severe stenosis. laryngeal margin hypopharyngeal mucosa appeared highly inflammatory fibrinous deposits....