A5034931288- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- HER2/EGFR in Cancer Research
- Gastrointestinal Tumor Research and Treatment
- Eosinophilic Disorders and Syndromes
- Statistical Methods in Clinical Trials
- Patient Safety and Medication Errors
- Analytical Methods in Pharmaceuticals
- Health, Medicine and Society
- Disaster Response and Management
- PI3K/AKT/mTOR signaling in cancer
- Safe Handling of Antineoplastic Drugs
- HIV/AIDS drug development and treatment
- Medication Adherence and Compliance
- Computational Drug Discovery Methods
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Platelet Disorders and Treatments
- Emergency and Acute Care Studies
- COVID-19 Clinical Research Studies
- HIV/AIDS Research and Interventions
- Pharmacy and Medical Practices
University of Lausanne
2015-2024
University of Geneva
2013-2024
Pharmacy of the Eastern Vaud Hospitals
2015-2024
École Polytechnique Fédérale de Lausanne
2023
HES-SO University of Applied Sciences and Arts Western Switzerland
2019-2022
Medical University of Silesia
2022
Dr Gray's Hospital
2020
Aberdeen Royal Infirmary
2020
Japan Organization of Occupational Health and Safety
2020
Yokohama Rosai Hospital
2020
The aims of this observational study were to assess the variability in imatinib pharmacokinetics and explore relationship between its disposition various biological covariates, especially plasma alpha1-acid glycoprotein concentrations.A population pharmacokinetic analysis was performed using NONMEM based on 321 samples from 59 patients with either chronic myeloid leukaemia or gastrointestinal stromal tumours. influence covariates oral clearance volume distribution examined. Furthermore, vivo...
Therapeutic drug monitoring (TDM) may contribute to optimizing the efficacy and safety of antifungal therapy because large variability in pharmacokinetics. Rapid, sensitive, selective laboratory methods are needed for efficient TDM. Quantification several antifungals a single analytical run best fulfill these requirements. We therefore developed multiplex ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method requiring 100 μl plasma simultaneous quantification...
Imatinib has revolutionised the treatment of chronic myeloid leukaemia (CML) and gastrointestinal stromal tumours (GIST). Using a nonlinear mixed effects population model, individual estimates pharmacokinetic parameters were derived used to estimate imatinib exposure (area under curve, AUC) in 58 patients. Plasma-free concentration was deduced from model incorporating plasma levels alpha1-acid glycoprotein. Associations between AUC (or clearance) response or incidence side explored by...
Objectives: To determine HIV-1 RNA in cerebrospinal fluid (CSF) of successfully treated patients and to evaluate if combination antiretroviral treatments with higher central nervous system penetration-effectiveness (CPE) achieve better CSF viral suppression. Methods: Viral loads (VLs) drug concentrations lopinavir, atazanavir, efavirenz were measured plasma CSF. The CPE was calculated using 2 different methods. Results: authors analyzed 87 samples 60 patients. In 4 samples, detectable 43–82...
Unpredictable pharmacokinetics of antibiotics in patients with life-threatening bacterial infections is associated drug under- or overdosing. Therapeutic monitoring (TDM) may guide dosing adjustment aimed at maximizing antibacterial efficacy and minimizing toxicity. Rapid accurate analytical methods are key for real-time TDM. Our objective was to develop a robust high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS) multiplex quantification plasma concentrations...
This study aims to investigate the clinical and demographic factors influencing gentamicin pharmacokinetics in a large cohort of unselected premature term newborns evaluate optimal regimens this population.All concentration data, along with characteristics, were retrieved from medical charts Neonatal Intensive Care Unit over 5 years within frame routine therapeutic drug monitoring programme. Data described using non-linear mixed-effects regression analysis ( nonmem®).A total 3039...
Abstract Besides affecting the systemic bioavailability of parent drug, drug metabolizing enzymes (DMEs) may produce bioactive and/or toxic metabolites clinical interest. We have investigated capability to analyze simultaneously and newly identified in patients' plasma by liquid chromatography coupled tandem mass spectrometry (LC–MS/MS). The anticancer imatinib, was chosen as a model because it has opened new area cancer therapy is given orally chronically. In addition, resistance rare but...