A5005165503- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- COVID-19 Impact on Reproduction
- Congenital Diaphragmatic Hernia Studies
- Antibiotics Pharmacokinetics and Efficacy
- Infant Nutrition and Health
- Neonatal and fetal brain pathology
- Emergency and Acute Care Studies
- Preterm Birth and Chorioamnionitis
- Immune Response and Inflammation
- Receptor Mechanisms and Signaling
- Antimicrobial Resistance in Staphylococcus
- Macrophage Migration Inhibitory Factor
- Kawasaki Disease and Coronary Complications
- Neonatal Health and Biochemistry
- Delphi Technique in Research
- Pregnancy and Medication Impact
- Facial Nerve Paralysis Treatment and Research
- Maternal and fetal healthcare
- Pharmaceutical studies and practices
- Child and Adolescent Health
- Obstructive Sleep Apnea Research
University of Lausanne
2016-2025
University Hospital of Lausanne
2006-2024
Washington University in St. Louis
2024
Sotiria General Hospital
2023
Patan Academy of Health Sciences
2023
Panagiotis & Aglaia Kyriakou Children's Hospital
2023
National and Kapodistrian University of Athens
2023
Complejo Hospitalario Universitario de Santiago
2023
Instituto de Investigación Sanitaria de Santiago
2018-2023
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2022-2023
OPINION article Front. Public Health, 08 May 2020Sec. Infectious Diseases – Surveillance, Prevention and Treatment Volume 8 - 2020 | https://doi.org/10.3389/fpubh.2020.00186
The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on effectiveness and safety EOS essential inform clinicians considering implementation.To assess association between management guided by (compared with conventional strategies) reduction in antibiotic therapy newborns.Electronic searches MEDLINE, Embase, Web Science, Google Scholar were conducted from 2011 (introduction...
Pregnant women may be at higher risk of severe complications associated with the acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which lead to obstetrical complications. We performed a case control study comparing pregnant disease 19 (cases) milder form (controls) enrolled in COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, immediate neonatal outcomes were assessed. A total 926 positive test SARS-CoV-2 included, among 92 (9.9%)...
Administration of probiotics to premature newborns has been shown prevent necrotizing enterocolitis and reduce all-cause mortality.In our hospital, we documented 2 cases Bifidobacterium longum subspecies infantis bacteremia in receiving probiotics.By comparative genomics, confirmed that the strains isolated from each patient originated probiotics.
Newborns are particularly susceptible to bacterial infections due qualitative and quantitative deficiencies of the neonatal innate immune system. However, mechanisms underlying these poorly understood. Given that fetuses exposed high concentrations estradiol progesterone during gestation at time delivery, we analyzed effects hormones on response cells endotoxin, lipopeptide, Escherichia coli group B Streptococcus, two most common causes early-onset sepsis. Here show present in umbilical cord...
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare and lethal developmental disorder the lung defined by constellation characteristic histopathological features. Nonpulmonary anomalies involving organs gastrointestinal, cardiovascular, genitourinary systems have been identified in approximately 80% patients ACD/MPV. We collected DNA pathological samples from more than 90 infants ACD/MPV their family members. Since publication our initial report four point...
Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along EOS incidence are needed to provide a basis for future interventions aimed at safely reducing exposure.To compare early postnatal antibiotics, EOS, mortality among different networks high-income countries.This retrospective, cross-sectional study...
Abstract Introduction Cefepime has been associated with a greater risk of mortality than other beta-lactams in patients treated for severe sepsis. Hypotheses this failure include possible hidden side-effects (for example, neurological) or inappropriate pharmacokinetic/pharmacodynamic (PK/PD) parameters bacteria cefepime minimal inhibitory concentrations (MIC) at the highest limits susceptibility (8 mg/l) intermediate-resistance (16 pathogens such as Enterobacteriaceae , Pseudomonas...
The vulnerability to infection of newborns is associated with a limited ability mount efficient immune responses. High concentrations adenosine and prostaglandins in the fetal neonatal circulation hamper antimicrobial responses newborn cells. However, existence mechanisms counterbalancing immunosuppression has not been investigated. Remarkably, circulating levels macrophage migration inhibitory factor (MIF), proinflammatory immunoregulatory cytokine expressed constitutively, were 10-fold...
Surfactant protein (SP)-A and SP-D, members of the collectin family, are involved in innate host defenses against various bacterial viral pathogens. In this study, we asked whether SP-A SP-D enhance clearance a nonmucoid strain Pseudomonas aeruginosa from lungs. We infected mice deficient (SP-A-/-), (SP-D-/-) both pulmonary collectins (SP-AD-/-) by intratracheal administration P. aeruginosa. Six hours after infection, counts were significantly higher SP-A-/-, SP-D-/-, SP-AD-/- compared with...
This study aims to investigate the clinical and demographic factors influencing gentamicin pharmacokinetics in a large cohort of unselected premature term newborns evaluate optimal regimens this population.All concentration data, along with characteristics, were retrieved from medical charts Neonatal Intensive Care Unit over 5 years within frame routine therapeutic drug monitoring programme. Data described using non-linear mixed-effects regression analysis ( nonmem®).A total 3039...
Uncertainty about the presence of infection results in unnecessary and prolonged empiric antibiotic treatment newborns at risk for early-onset sepsis (EOS). This study evaluates impact this uncertainty on diversity management.A web-based survey with questions addressing management risk-adjusted scenarios was performed Europe, North America, Australia. Published national guidelines (n = 5) were reviewed compared survey.439 Clinicians (68% neonatologists) from 16 countries completed survey. In...
Objective To evaluate the impact of gentamicin exposure on sensorineural hearing loss (SNHL) in very low birth weight (VLBW) infants. Methods Exposure to was determined infants born between 1993 and 2010 at a gestational age < 32 weeks and/or with birthweight 1500 g, who presented SNHL during first 5 years life. For each case, we selected two controls matched for gender, age, birthweight, year birth. Results We identified 25 affected by SNHL, leading an incidence 1.58% our population VLBW...
Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta compromise its function. We present two cases of decreased fetal movements abnormal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 32 1 weeks gestation, leading to brain injury. Placental examination revealed extensive multifocal chronic intervillositis, with intense...