A5039227159- Spinal Dysraphism and Malformations
- Assisted Reproductive Technology and Twin Pregnancy
- Fetal and Pediatric Neurological Disorders
- Congenital Anomalies and Fetal Surgery
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Cerebrospinal fluid and hydrocephalus
- Tissue Engineering and Regenerative Medicine
- Congenital Diaphragmatic Hernia Studies
- Urological Disorders and Treatments
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Pregnancy-related medical research
- Bone fractures and treatments
- Mesenchymal stem cell research
- COVID-19 Impact on Reproduction
- Maternal and fetal healthcare
- Hernia repair and management
- Grief, Bereavement, and Mental Health
- Connective tissue disorders research
- Olfactory and Sensory Function Studies
- Maternal Mental Health During Pregnancy and Postpartum
University Hospital of Zurich
2016-2025
University of Zurich
2015-2025
Center for Pediatric Endocrinology Zurich
2013-2025
University of Bern
2024
University of Lausanne
2024
Kantonsspital Winterthur
2024
Olgahospital
2015-2023
University Children's Hospital Zurich
2019-2023
Klinik für Frauenheilkunde
2002-2023
Fetal Medicine Foundation
2022
Pregnant women may be at higher risk of severe complications associated with the acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which lead to obstetrical complications. We performed a case control study comparing pregnant disease 19 (cases) milder form (controls) enrolled in COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, immediate neonatal outcomes were assessed. A total 926 positive test SARS-CoV-2 included, among 92 (9.9%)...
Treating vascular diseases in the brain requires access to affected region inside body. This is usually accomplished through a minimally invasive technique that involves use of long, thin devices, such as wires and tubes, are manually maneuvered by clinician within bloodstream. By pushing, pulling, twisting, these devices navigated tortuous pathways blood vessels. The outcome procedure heavily relies on clinician’s skill device’s ability navigate target bloodstream, which often inhibited...
The Management of Myelomeningocele Study, a.k.a. the MOMS trial, was published in 2011 New England Journal Medicine. This prospective randomized controlled trial proved to be a milestone publication that provided definitive evidence fetal surgery is novel standard care for select fetuses with spina bifida aperta (SB). goal our study assess whether center can match these benchmark results.Our conducted according protocol using same inclusion and exclusion criteria looked at outcome parameters...
We hypothesize that after publication of the quintessence MOMS trial, eligibility criteria for prenatal spina bifida (SB) repair may be modified if a tenable argumentation underlies this decision.Our first 154 fetal surgery patients were analyzed with particular focus on how many, which, and why original criteria, set forth by Trial Protocol, disobeyed, what eventually detectable, negative positive impacts these deviations outcomes were.A total 152 (2 missing consent) included (100%). In 69...
ABSTRACT The human brain connectome is characterized by the duality of highly modular structure and efficient integration, supporting information processing. Newborns with congenital heart disease (CHD), prematurity, or spina bifida aperta (SBA) constitute a population at risk for altered development developmental delay (DD). We hypothesize that, independent etiology, alterations connectomic organization reflect neural circuitry impairments in cognitive DD. Our study aim to address this...
Systemic drug administration often causes off-target effects limiting the efficacy of advanced therapies. Targeted delivery approaches increase local concentrations at diseased site while minimizing systemic exposure. We present a magnetically guided microrobotic system capable precise navigation under physiological conditions. This platform integrates clinical electromagnetic system, custom-designed release catheter, and dissolvable capsule for accurate therapeutic delivery. In vitro tests...
Abstract The treatment of large bone defects requires tissue substitutes. However, the lack accessible autologous bone, especially in newborns with spina bifida or cleft palate conditions, severely limits therapeutic options involving grafts. Here, an engineering approach to reconstruct is presented by combining human amniocentesis‐derived amniotic fluid progenitor cells (hAFCs) and a biomimetic, injectable, fully synthetic poly(ethylene glycol) hydrogel that crosslinked enzymatically...
Abstract Purpose Induction of labor as well delivery in twin pregnancies bears specific risks. The goal this study was to analyze the mode and influence induction on cesarean (CD) rate perinatal outcome identify risk factors for CD an intertwin interval ≥ 15 min. Methods This single-center retrospective cohort analyzed 267 pregnancies. Inclusion criteria vaginal twins are gestational age (GA) > 34 weeks, leading cephalic presentation, estimated weight difference ≤ 500 g no previous...
Iatrogenic preterm premature rupture of membranes (iPPROM), the main complication invasive interventions in prenatal period, seriously limits benefit diagnostic or surgical procedures. This study aimed to evaluate preventive plugging punctured fetal an ex vivo situation using a new mussel-mimetic tissue adhesive (mussel glue) inhibit leakage.A novel biomechanical test device that tests closure injured under near-physiological conditions was used. Mussel glue, poly(ethylene glycol)-based...
The objective of this study was to determine for the first time reliability and diagnostic power high-resolution microarray testing in routine prenatal diagnostics.We applied chromosomal 464 cytogenetically normal samples with any indication invasive testing.High-resolution revealed a yield 6.9% 1.6% cases fetal ultrasound anomalies advanced maternal age (AMA), respectively, which is similar previous studies using low-resolution microarrays. In three (0.6%) additional an AMA, aberration...
To compare tocolysis with magnesium sulfate versus atosiban regarding the occurrence of short-term preterm labor and maternal side effects during after open fetal myelomeningocele (MMC) repair.A prospective nonrandomized cohort study was performed including 30 MMC cases. The first 15 cases (group 1) received according to MOMS protocol. In following 2), substituted by atosiban. Chorioamniotic membrane separation (CMS), premature prelabor rupture membranes (PPROM), delivery <3 weeks repair,...