A5079115453- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and Perinatal Health Interventions
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Urological Disorders and Treatments
- Neonatal Respiratory Health Research
- Hernia repair and management
- Prenatal Screening and Diagnostics
- Grief, Bereavement, and Mental Health
- Cardiovascular Health and Disease Prevention
- Family and Disability Support Research
- Teratomas and Epidermoid Cysts
- Pediatric Urology and Nephrology Studies
- Neurological Complications and Syndromes
- Tissue Engineering and Regenerative Medicine
- Cerebrovascular and Carotid Artery Diseases
- Pancreatitis Pathology and Treatment
- Neonatal and Maternal Infections
- Neonatal and fetal brain pathology
University Hospital of Zurich
2017-2025
University of Zurich
2018-2025
Kantonsspital Winterthur
2024
University Children's Hospital Zurich
2022-2023
Center for Pediatric Endocrinology Zurich
2020-2023
Fetal Medicine Foundation
2022
Klinik für Frauenheilkunde
2017-2022
Olgahospital
2017-2022
We hypothesize that after publication of the quintessence MOMS trial, eligibility criteria for prenatal spina bifida (SB) repair may be modified if a tenable argumentation underlies this decision.Our first 154 fetal surgery patients were analyzed with particular focus on how many, which, and why original criteria, set forth by Trial Protocol, disobeyed, what eventually detectable, negative positive impacts these deviations outcomes were.A total 152 (2 missing consent) included (100%). In 69...
Abstract Purpose Induction of labor as well delivery in twin pregnancies bears specific risks. The goal this study was to analyze the mode and influence induction on cesarean (CD) rate perinatal outcome identify risk factors for CD an intertwin interval ≥ 15 min. Methods This single-center retrospective cohort analyzed 267 pregnancies. Inclusion criteria vaginal twins are gestational age (GA) > 34 weeks, leading cephalic presentation, estimated weight difference ≤ 500 g no previous...
Objective To systematically categorise all maternal and fetal intervention‐related complications after open myelomeningocele (fMMC) repair of the first 124 cases operated at Zurich Centre for Fetal Diagnosis Therapy. Design A prospective cohort study. Setting Single centre. Population Mothers fetuses fMMC repair. Methods Between 2010 2019, we collected entered following into Clavien–Dindo classification. For complications, a classification system based on Medical Dictionary Regulatory...
<b><i>Introduction:</i></b> The Management of Myelomeningocele Study (MOMS) eligibility criteria preclude in utero surgery for fetal spina bifida (fSB) when the maternal body mass index (BMI) is ≥35 kg/m<sup>2</sup>. Some centers still respect this criterion, while others, like ours, do not. This study aimed to assess whether and safety compromised with higher BMIs. <b><i>Methods:</i></b> Data 192 patients open fSB repair at our...
<b><i>Introduction:</i></b> Despite undoubtable benefits of open fetal myelomeningocele (fMMC) repair, there are considerable maternal risks. The aim this study was to evaluate and systematically categorize complications after fMMC repair. <b><i>Methods:</i></b> We analyzed data 40 repairs performed at the Zurich Center for Fetal Diagnosis Therapy. Maternal were classified according a 5-level grading system based on classification surgical...
Fetal myelomeningocele (fMMC) repair is a therapeutic option in selected cases. This study aimed to identify risk factors for preterm birth (PTB) following open fMMC repair.Sixty-seven women underwent and delivered baby between 2010 2018 at our center. Demographic, surgical, pregnancy complications, including potential PTB such as premature rupture of membranes (PPROM), chorioamniotic membrane separation (CMS), placental abruption were evaluated.Maternal body mass index, maternal age,...
The aim of this study was to describe the sonographic evolution fetal head circumference (HC) and width posterior horn lateral ventricle (Vp) after open myelomeningocele (fMMC) repair assess whether pre- or postoperative measurements are helpful predict need for shunting during first year life. All 30 children older than one by January 2017 who previously had fMMC at Zurich Center Fetal Diagnosis Therapy were included. Sonographic HC Vp before assessed compared between non-shunted (N = 16)...
The benefits of fetal surgery are impaired by the high incidence iatrogenic preterm prelabor rupture membranes (iPPROM), for which chorioamniotic separation has been suggested as a potential initiator. Despite urgent need to prevent iPPROM sealing fetoscopic puncture site after intervention, no approach clinically translated.
Abstract Fetoscopic interventions to treat fetal anomalies are currently performed for a variety of conditions. Depending on the procedure, preterm rupture membranes (FMs) happens in around 30% cases, potentially leading birth and morbidity mortality. Here, capacity modular transglutaminase crosslinked poly(ethylene glycol) (TG‐PEG) hydrogels that release platelet‐derived growth factor (PDGF)‐BB promote FM healing is described. In vitro, such factor‐loaded able stimulate amniotic cell...
In non-pregnant populations, pancreatic stone protein (PSP) has been reported to have a higher diagnostic performance for identifying severe inflammatory and infectious disease than other established biomarkers.To generate reference values serum PSP in pregnancy compare them the of general healthy population.A prospective cohort study.A single center.Healthy women with singleton multiple pregnancies.This is single-center study. Between 2013 2021, samples 5 mL peripheral blood were drawn from...
<b><i>Introduction:</i></b> Open fetal myelomeningocele (fMMC) repair is nowadays a therapeutic option in selected cases. We aimed to evaluate changes maternal and outcome after fMMC during the first 8 years of experience at tertiary referral medicine center Switzerland. <b><i>Materials Methods:</i></b> Between 2010 2018, delivery neonate via planned cesarean section was performed 67 Cases were retrospectively stratified into 2 groups:...
Iatrogenic preterm premature rupture of the membrane remains Achille's heel fetoscopy. The aim this study was to show in vivo feasibility fetal (FM) defect sealing by application tissue glues with umbrella-shaped receptors.First, we adapted our previously described ex strategy and evaluated adhesion strength different glues, Histoacryl® Glubran2®, bonding polytetrafluoroethylene or silicone encapsulated nitinol glue receptor human FM. Then, exposed pregnant sheep uterus through a laparotomy...
One of the main concerns for all fetal surgeries is risk preterm delivery due to prelabor rupture membranes (iPPROM). Clinical approaches seal membrane (FM) defects are missing lack appropriate strategies apply sealing biomaterials at defect site.Here, we test performance a previously developed strategy FM with cyanoacrylate-based patches in an ovine model up 24 days after application.Patches sealed tightly fetoscopy-induced and remained firmly attached over 10 days. At treatment, 100%...
Background: Pancreatic stone protein (PSP) is a biochemical serum marker that contains levels are elevated in various inflammatory and infectious diseases. The role of PSP the diagnosis these diseases seems to be more important compared clinically established markers discriminating severity same Standard values for pregnant women relation gestational age have been reported recently. Additionally, increased observed associated with renal dysfunction women. aim this study evaluate diagnostic...
Increased pulse wave reflection in the fetal arterial system, illustrated by a second systolic peak (M-sign) middle cerebral artery (MCA) Doppler waveforms, allows interpretation of systemic vasoconstriction. Little is known about vascular regulation during spina bifida (fSB) repair. Therefore, aim this study was to analyze MCA-Doppler waveform changes before, during, and after fSB repair.31 pregnant women who underwent repair were included. Fetal waveforms prospectively analyzed repair,...
<b><i>Introduction:</i></b> The reason for the absence of fetal membrane (FM) healing after a fetoscopic intervention is still unknown. We hypothesize that lack robust miniaturized models to study preterm FM functions currently hampering development new treatments healing. Specifically, with minimal amounts tissue are lacking. <b><i>Methods:</i></b> In this study, we collected FMs from planned cesarean deliveries and developed different ex vivo...
Abstract Purpose The aim was to describe the sonographic follow-up of hindbrain herniation (HH), banana and lemon sign after fetal myelomeningocele (fMMC) repair, time disappearance these signs intervention, investigate any predictive value for necessity shunting during infant’s first year life. Additionally, evolution transcerebellar diameter (TCD) before intervention assessed. Patients Methods 50 patients that underwent fMMC repair at Zurich Center Fetal Diagnosis Therapy...
The goal of this study was to assess the accuracy prenatal anatomical level determination by ultrasound (US) and magnetic resonance imaging (MRI) analyzing congruence with "true" identified postnatal MRI. first 60 patients undergoing fetal myelomeningocele surgery at Zurich Center for Fetal Diangosis Therapy were included in study. Anatomical levels (i. e., dysraphic vertebra) determined US MRI compared agreement between modalities evaluated a Cohen's kappa test. Results > 0.6 interpreted as...
Abstract Fetal therapies regularly result in iatrogenic preterm premature rupture of the fetal membranes (iPPROM), which is associated with birth. Biomaterials that promote healing traumatized (FMs) may prevent iPPROM‐associated births, addressing this unmet clinical need. Here, a fully defined synthetic poly(ethylene glycol) (PEG) hydrogel developed to study functions human amnion‐derived mesenchymal stromal cells (hAMCs) 3D cultures. A pipeline analyze extracellular matrix (ECM) proteins...