A5079918230- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Pelvic floor disorders treatments
- Fetal and Pediatric Neurological Disorders
- Hernia repair and management
- Pregnancy and preeclampsia studies
- Tracheal and airway disorders
- Spinal Dysraphism and Malformations
- Anorectal Disease Treatments and Outcomes
- Congenital Heart Disease Studies
- Pelvic and Acetabular Injuries
- Urological Disorders and Treatments
- Esophageal and GI Pathology
- Ectopic Pregnancy Diagnosis and Management
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Neonatal and fetal brain pathology
- Gynecological conditions and treatments
- Anesthesia and Neurotoxicity Research
- Tissue Engineering and Regenerative Medicine
- Preterm Birth and Chorioamnionitis
- Intestinal Malrotation and Obstruction Disorders
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2016-2025
University College Hospital
2017-2025
University College London
2016-2025
London Women's Clinic
2016-2025
Australia New Zealand Gynaecological Oncology Group
2024
Centre Hospitalier Universitaire de Clermont-Ferrand
2023
University Hospital of Geneva
2023
Centre hospitalier régional de la Citadelle
2023
University of Liège
2023
Monochorionic twin pregnancies complicated by severe twin-to-twin transfusion syndrome at midgestation can be treated either serial amnioreduction (removal of large volumes amniotic fluid) or selective fetoscopic laser coagulation the communicating vessels on chorionic plate. We conducted a randomized trial to compare efficacy and safety these two treatments.Pregnant women with before 26 weeks gestation were randomly assigned therapy amnioreduction. assessed perinatal survival least one (a...
Convolutional neural networks (CNNs) have achieved state-of-the-art performance for automatic medical image segmentation. However, they not demonstrated sufficiently accurate and robust results clinical use. In addition, are limited by the lack of image-specific adaptation generalizability to previously unseen object classes (a.k.a. zero-shot learning). To address these problems, we propose a novel deep learning-based interactive segmentation framework incorporating CNNs into bounding box...
Abstract Objective To assess the value of antenatally determined observed to expected fetal lung area head circumference ratio (LHR) in prediction postnatal survival isolated, congenital diaphragmatic hernia (CDH). Methods Two groups fetuses were examined. The first group included 650 normal at 12–32 weeks' gestation, and data collected used establish a range LHR with gestational age. second retrospective multicenter study 354 isolated CDH which was measured on one occasion 18–38 gestation....
In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, number of participating centers has been raised from 13 to 22. this article relevant literature is updated, and consensus reached between members CDH Consortium. Key updated recommendations are: (1) planned delivery after gestational age 39 weeks in high-volume tertiary center; (2) neuromuscular blocking agents be avoided during initial room; (3) adapt...
Despite the state-of-the-art performance for medical image segmentation, deep convolutional neural networks (CNNs) have rarely provided uncertainty estimations regarding their segmentation outputs, e.g., model (epistemic) and image-based (aleatoric) uncertainties. In this work, we analyze these different types of uncertainties CNN-based 2D 3D tasks. We additionally propose a test-time augmentation-based aleatoric to effect transformations input on output. Test-time augmentation has been...
Accurate medical image segmentation is essential for diagnosis and treatment planning of diseases. Convolutional Neural Networks (CNNs) have achieved state-of-the-art performance automatic segmentation. However, they are still challenged by complicated conditions where the target has large variations position, shape scale, existing CNNs a poor explainability that limits their application to clinical decisions. In this work, we make extensive use multiple attentions in CNN architecture...
To evaluate a classification of selective intrauterine growth restriction (sIUGR) in monochorionic (MC) twins based on the characteristics umbilical artery (UA) Doppler flow smaller twin, terms association with clinical outcome and pattern placental anastomoses.One hundred thirty-four MC diagnosed sIUGR at 18-26 weeks were classified as Type I (UA positive diastolic flow, n = 39), II (persistent absent or reversed end-diastolic 30) III (intermittent 65). Perinatal outcome, sharing...
Abstract Introduction and hypothesis A terminology standardized classification has yet to be developed for those complications arising directly from the insertion of synthetic (prostheses) biological (grafts) materials in female pelvic floor surgery. Methods This report on above combines input members Standardization Terminology Committees two International Organizations, Urogynecological Association (IUGA) Continence Society (ICS) a Joint IUGA/ICS Working Group Complications Terminology,...
Congenital diaphragmatic hernia (CDH) with liver herniation and a lung area to head circumference ratio (LHR) < 1 [corrected] is associated high rate of neonatal death due pulmonary hypoplasia.We report the development minimally invasive reversible fetoscopic tracheal occlusion (FETO) balloon, carried out in 21 consecutive fetuses severe CDH.Endotracheal placement balloon was successfully performed all cases mean duration operation 20 (range, 5-54) min. The median gestation at FETO 26 25-33)...
To examine operative and perinatal aspects of fetal endoscopic tracheal occlusion (FETO) in congenital diaphragmatic hernia (CDH).This was a multicenter study singleton pregnancies with CDH treated by FETO. The entry criteria for FETO were severe on the basis sonographic evidence intrathoracic herniation liver low lung area to head circumference ratio (LHR) defined as observed expected normal mean gestation (o/e LHR) equivalent an LHR 1 or less.FETO carried out 210 cases, including 175 cases...
Accurate medical image segmentation is essential for diagnosis, surgical planning and many other applications. Convolutional Neural Networks (CNNs) have become the state-of-the-art automatic methods. However, fully results may still need to be refined accurate robust enough clinical use. We propose a deep learning-based interactive method improve obtained by an CNN reduce user interactions during refinement higher accuracy. use one obtain initial segmentation, on which are added indicate...
Observational studies have shown that fetoscopic endoluminal tracheal occlusion (FETO) has been associated with increased survival among infants severe pulmonary hypoplasia due to isolated congenital diaphragmatic hernia on the left side, but data from randomized trials are lacking.
Background— Pregnancy provides a unique model to study the adaptation of heart in physiological situation transient load changes. The aim this was assess performance left ventricle (LV) normal, uncomplicated pregnancies while considering actual LV and shape. Methods Results— Serial echocardiographic examinations were performed 51 women each pregnancy trimester 3 6 months after delivery. Data from 10 nulliparous, age-matched used as control. Conventional parameters function (ejection...
High-resolution volume reconstruction from multiple motion-corrupted stacks of 2D slices plays an increasing role for fetal brain Magnetic Resonance Imaging (MRI) studies. Currently existing methods are time-consuming and often require user interactions to localize extract the several slices. We propose a fully automatic framework that consists four stages: 1) localization based on coarse segmentation by Convolutional Neural Network (CNN), 2) fine another CNN trained with multi-scale loss...
Fetoscopic endoluminal tracheal occlusion (FETO) has been associated with increased postnatal survival among infants severe pulmonary hypoplasia due to isolated congenital diaphragmatic hernia on the left side, but data are lacking inform its effects in moderate disease.
Pregnant women may be at higher risk of severe complications associated with the acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which lead to obstetrical complications. We performed a case control study comparing pregnant disease 19 (cases) milder form (controls) enrolled in COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, immediate neonatal outcomes were assessed. A total 926 positive test SARS-CoV-2 included, among 92 (9.9%)...
Abstract Objective To investigate the potential value of antenatally determined intrathoracic herniation liver and ratio fetal lung area to head circumference (LHR) in prediction postnatal survival isolated, left‐sided congenital diaphragmatic hernia (CDH). Methods In this multicenter study, we searched antenatal‐CDH‐Registry for fetuses with isolated CDH that were liveborn after 30 weeks gestation followed up postnatally at least 3 months discharge from hospital. The patients subdivided...