A5056832725- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Preterm Birth and Chorioamnionitis
- Congenital Diaphragmatic Hernia Studies
- Fetal and Pediatric Neurological Disorders
- Birth, Development, and Health
- Pregnancy-related medical research
- Congenital Anomalies and Fetal Surgery
- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- COVID-19 Impact on Reproduction
- Maternal and fetal healthcare
- Gestational Diabetes Research and Management
- Spinal Dysraphism and Malformations
- Ectopic Pregnancy Diagnosis and Management
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Maternal and Perinatal Health Interventions
- Cerebrospinal fluid and hydrocephalus
- Maternal Mental Health During Pregnancy and Postpartum
- Teratomas and Epidermoid Cysts
- Neonatal and fetal brain pathology
- Pregnancy and Medication Impact
- Parvovirus B19 Infection Studies
Vall d'Hebron Hospital Universitari
2016-2025
Universitat Autònoma de Barcelona
2016-2025
Vall d'Hebron Institut de Recerca
2003-2024
Hebron University
2006-2024
Universitat de Barcelona
2021-2024
Hospital Clínic de Barcelona
2023-2024
Josep Carreras Leukaemia Research Institute
2021-2024
Universitat de Vic - Universitat Central de Catalunya
2024
Departament de Salut
2024
Consorci Sanitari de Terrassa
2023
To evaluate a classification of selective intrauterine growth restriction (sIUGR) in monochorionic (MC) twins based on the characteristics umbilical artery (UA) Doppler flow smaller twin, terms association with clinical outcome and pattern placental anastomoses.One hundred thirty-four MC diagnosed sIUGR at 18-26 weeks were classified as Type I (UA positive diastolic flow, n = 39), II (persistent absent or reversed end-diastolic 30) III (intermittent 65). Perinatal outcome, sharing...
Objectives To investigate the incidence of clinical, ultrasonographic and biochemical findings related to pre‐eclampsia (PE) in pregnancies with COVID‐19, assess their accuracy differentiate between PE PE‐like features associated COVID‐19. Design A prospective, observational study. Setting Tertiary referral hospital. Participants Singleton COVID‐19 at >20 +0 weeks. Methods Forty‐two consecutive were recruited classified into two groups: severe non‐severe according occurrence pneumonia....
OBJECTIVE: To describe development of a two-port fetoscopic technique for spina bifida repair in the exteriorized, carbon dioxide-filled uterus and report early results two cohorts patients: first 15 treated with an iterative latter 13 standardized technique. METHODS: This was retrospective cohort study (2014–2016). All patients met Management Myelomeningocele Study selection criteria. The intraoperative approach then standardized. Obstetric, maternal, fetal, neonatal outcomes were compared....
Abstract Objective To determine whether a modified myocardial performance index (Mod‐MPI) involving assessment of the movements (clicks) mitral valve (MV) and aortic (AV), improves intra‐ interobserver agreement as compared to previously reported method for MPI estimation. Methods The Mod‐MPI was recorded by two experienced operators in left cardiac chambers 25 normally grown fetuses using pulsed Doppler ultrasonography. isovolumetric contraction time (ICT) measured from closure MV opening...
Abstract Objective To assess the incidence of parenchymal lesions on early and late neonatal brain scans its association with presence or absence intermittent absent reversed end‐diastolic umbilical artery flow velocity (A/REDV) in monochorionic twins complicated by selective intrauterine growth restriction (IUGR), as compared to dichorionic without IUGR. Methods This was a prospective cohort study involving 42 diagnosed IUGR managed expectantly. The A/REDV recorded all cases. group ( n =...
Animal models showed that angiogenesis is related to abnormal heart development. Our objectives were ascertain whether a relationship exists between congenital defects (CHDs) and angiogenic/anti-angiogenic imbalance in maternal foetal blood study the expression of angiogenic factors heart.Maternal cord placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) endoglin (sEng) compared 65 cases CHD 204 normal controls. Angiogenic markers hypoxia measured tissue from 23...
To compare the outcome of pregnancy in cohorts women with singleton and history preterm birth sonographic short cervix managed different treatment protocols, namely cerclage, vaginal progesterone or cervical pessary.This was a comparison three management protocols for high risk because prior spontaneous before 34 weeks shortened length detected by transvaginal ultrasound. The study included 142 who were initially treated cerclage (USA), 59 (UK) 42 pessary (Spain). Perinatal outcomes compared...
BackgroundEarly identification of women with an increased risk for preeclampsia is utmost importance to minimize adverse perinatal events. Models developed until now (mainly multiparametric algorithms) are thought be overfitted the derivation population, which may affect their reliability when applied other populations. Options allowing adaptation a variety populations needed.ObjectiveThe objective study was assess performance first-trimester multivariate Gaussian distribution model...
Aspirin reduces the incidence of preterm preeclampsia by 62% in pregnant individuals at high risk preeclampsia. However, aspirin might be associated with an increased peripartum bleeding, which could mitigated discontinuing before term (37 weeks gestation) and accurate selection higher first trimester pregnancy.To determine whether discontinuation normal soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1:PlGF) ratio between 24 28 gestation was noninferior continuation...
To document perinatal outcomes following use of the 'Solomon technique' in selective photocoagulation placental anastomoses for severe twin-twin transfusion syndrome (TTTS).Between January 2010 and July 2012, data were collected from 102 consecutive monochorionic twin pregnancies complicated by TTTS that underwent fetoscopic laser ablation at four different centers. We compared between subjects coagulation using Solomon technique (cases) those without this procedure (controls).Of examined,...
Abstract Objective To investigate the value of fetal stomach position in predicting postnatal outcome left‐sided congenital diaphragmatic hernia ( CDH ) with and without fetoscopic endoluminal tracheal occlusion FETO ). Methods This was a retrospective review cases that were expectantly managed or treated , assessed from May 2008 to October 2013, which we graded, on scale 1–4, four‐chamber view heart respect thoracic structures. Logistic regression analysis used effect management center...
Anxiety and depression during pregnancy can lead to adverse maternal neonatal outcomes. The SARS CoV-2 pandemic, the complete lockdown required first wave in most countries are stressors for pregnant women anxiety pregnancy. aim of this study was explore symptoms, social support lockdown, as well demographic risk factors.A prospective cohort performed at Hospital Universitari Vall d'Hebron, Barcelona, including attending antenatal clinic SARS-CoV2 period. Three questionnaires were...
Abstract Objective To evaluate the incidence and clinical relevance of intermittent absent and/or reversed diastolic flow on umbilical artery Doppler in different groups monochorionic twin pregnancies. Methods This was a prospective study involving three pregnancies: Group 1: controls followed fortnightly from first trimester ( n = 80); 2: cases with selective intrauterine growth restriction 40); 3: severe twin–twin transfusion syndrome 50). The presence persistence over time end‐diastolic...
To evaluate the effect of early fetoscopic tracheal occlusion (FETO) (22-24 weeks' gestation) on pulmonary response and neonatal survival in cases extremely severe isolated congenital diaphragmatic hernia (CDH).This was a multicenter study involving fetuses with CDH (lung-to-head ratio < 0.70, liver herniation into thoracic cavity no other detectable anomalies). Between August 2010 December 2011, eight underwent FETO. Data were compared nine that standard FETO 10 without procedure from...
To determine the longitudinal behavior of fetal biometric measures and cerebroplacental hemodynamics throughout gestation in fetuses with congenital heart disease (CHD).Fetal biometry Doppler (uterine artery (UtA), umbilical (UA) middle cerebral (MCA)) were measured serially a cohort consecutive diagnosed CHD. Evaluations made at various time points, from diagnosis (20-25 weeks) to delivery, least two measurements per fetus that 2 weeks apart. Fetuses classified into three groups according...
To report our preliminary experience in the use of prenatal ultrasound examination to assess lower-limb movements fetuses with myelomeningocele. We aimed determine accuracy this method establish segmental level neurological lesion, as is best known predictor future ability walk.This was a preliminary, observational study including myelomeningocele operated on prenatally. The patterns present and absent affected fetuses' lower limbs were evaluated systematically by examination. According...
Fetoscopic LASER coagulation of the placental anastomoses has changed prognosis twin-twin transfusion syndrome. However, prematurity rate in this cohort remains very high. To date, strategies proposed to decrease have shown inconclusive, if not unfavourable results.This is a randomised controlled trial investigate whether prophylactic cervical pessary will lower incidence preterm delivery cases syndrome requiring fetoscopic coagulation. Women eligible for study be after surgery and allocated...