A5035263374- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- COVID-19 Impact on Reproduction
- Cardiovascular Issues in Pregnancy
- Genetics and Neurodevelopmental Disorders
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and Medication Impact
- Fetal and Pediatric Neurological Disorders
- Preterm Birth and Chorioamnionitis
- COVID-19 and healthcare impacts
- Erythrocyte Function and Pathophysiology
- Bariatric Surgery and Outcomes
- Metabolism and Genetic Disorders
- Reproductive System and Pregnancy
- Amino Acid Enzymes and Metabolism
- Hemoglobinopathies and Related Disorders
- Maternal and Perinatal Health Interventions
- Blood groups and transfusion
- Obesity and Health Practices
- Organ Transplantation Techniques and Outcomes
- Genomics and Rare Diseases
- Prenatal Screening and Diagnostics
Hospital Universitari de Girona Doctor Josep Trueta
2020-2025
University of Girona
2022-2025
Universitat Autònoma de Barcelona
2023-2024
Vall d'Hebron Hospital Universitari
2024
Consorci Sanitari de Terrassa
2023
University Hospital Mútua de Terrassa
2023
Hospital Universitari Germans Trias i Pujol
2023
Mútua Terrassa
2023
Deleted Institution
2012
Aspirin reduces the incidence of preterm preeclampsia by 62% in pregnant individuals at high risk preeclampsia. However, aspirin might be associated with an increased peripartum bleeding, which could mitigated discontinuing before term (37 weeks gestation) and accurate selection higher first trimester pregnancy.To determine whether discontinuation normal soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1:PlGF) ratio between 24 28 gestation was noninferior continuation...
This study aims to evaluate the safety of discontinuing aspirin treatment at 24-28 weeks in women high risk after first-trimester combined screening for preeclampsia (PE) and normal placental growth factor (PlGF) levels gestation.
Background: To evaluate the impact of applying alternative diagnostic criteria for gestational diabetes mellitus (GDM) during COVID-19 pandemic on GDM prevalence, obstetrical and perinatal outcomes, costs, as compared to standard method. Methods: A cohort pregnant individuals undergoing GMD screening with method, which uses plasma glucose (fasting or non-fasting) HbA1c, was a Both cohorts were obtained from six hospitals across Catalonia, Spain, April 2020 2022. The primary outcome large age...
Abstract Objective To assess whether aspirin treatment can be discontinued in pregnancies with normal uterine artery pulsatility index (≤90th percentile) at 24–28 weeks. Design Post‐hoc analysis of a clinical trial. Setting Nine maternity hospitals Spain. Population or Sample Pregnant individuals high risk pre‐eclampsia 11–13 weeks and Doppler Methods All participants received daily dose 150 mg. Participants were randomly assigned, 1:1 ratio, either to continue until 36 (control group)...
The association between preeclampsia and coronavirus disease 2019 (COVID-19) is under study. Previous publications have hypothesized the existence of shared risk factors for both conditions or a deficient trophoblastic invasion as possible explanations this association. primary aim study was to examine baseline measured in first-trimester combined screening pregnant women with COVID-19 compared general population. A secondary compare among patients mild severe COVID-19.This an observational...
Pre-eclampsia affects 2%-8% of pregnancies and is one the leading causes maternal perinatal morbidity mortality. First-trimester screening using an algorithm that combines characteristics, mean arterial blood pressure, uterine artery pulsatility index biomarkers (pregnancy-associated plasma protein-A placental growth factor) method achieves a greater diagnostic accuracy. It has been shown daily salicylic acid administration before 16 weeks in women at high risk for pre-eclampsia can reduce...
( BJOG. 2024;131(3):334–342. doi: 10.1111/1471-0528.17631) Preeclampsia (PEC) is characterized by hypertension and proteinuria or organ dysfunction after 20 weeks of gestation. The cause the condition has not been fully elucidated; however, PEC associated with a defect in development placenta early-onset patients. In unaffected individuals, uterine artery flow impedance (UtA) decreases during early gestation through week 24. However, if pulsatility index (PI) UtA remains high, it sign...
Background: Autoimmune hemolytic anemia (AIHA) is a rare entity during pregnancy. The fetal risk determined primarily by the ability of autoantibodies to cross placental barrier. Currently, establishment standardized antenatal care in cases with AIHA remains as pending issue.Cases: Firstly, we describe case 17-week pregnant woman that was diagnosed cold agglutinin mediated (C3 and IgM) AIHA. Treatment started prednisone, showing initial improvement, but requiring intravenous gammaglobulins...
(JAMA. 2023;329:542–550) Globally, 70,000 maternal deaths and 500,000 fetal each year can be attributed to preeclampsia, which affects roughly 2-4% of pregnancies. Diagnosis preeclampsia falls into several categories depending on gestational age at diagnosis, with early-onset (delivery <34 wk), preterm <37 term or past 37 wk). Many serious complications associated a diagnosis including birth, growth restriction, placental abruption, seizures, others, earlier onset correlating more...
Fetal smallness affects 10% of pregnancies. Small fetuses are at a higher risk adverse outcomes. Their management using estimated fetal weight and feto-maternal Doppler has high sensitivity for outcomes; however, more than 60% electively delivered 37 to 38 weeks. On the other hand, classification angiogenic factors seems have lower false-positive rate. Here, we present protocol Growth Restriction Term Managed by Angiogenic Factors Versus Feto-Maternal (GRAFD) trial, which compares use manage...
Abstract GLYT1 encephalopathy is a form of glycine caused by disturbance transport. The phenotypic spectrum the disease has not yet been completely described, as only four unrelated families with disorder have reported to date. Common features affected patients include neonatal hypotonia, respiratory failure, encephalopathy, myoclonic jerks, dysmorphic features, and musculoeskeletal anomalies. All harbor biallelic genetic variants in SLC6A9 . SNP array together Sanger sequencing were...
Abstract We present a case of fetal akinesia deformation sequence due to nemaline myopathy (NM). In addition the muscle manifestations, prenatal observations included an enlarged subarachnoid space and delayed cortical development. Trio whole‐exome sequencing revealed de novo novel pathogenic variant in ACTA1 gene, which encodes skeletal alpha‐actin. Our findings suggest that brain abnormalities can occur prenatally NM support potential role alpha‐actin central nervous system.
Aim: To evaluate the impact of applying alternative diagnostic criteria for gestational diabetes mellitus (GDM) during COVID-19 pandemic on GDM prevalence, obstetrical and perinatal outcomes, costs, as compared to standard method. Methods: A cohort pregnant individuals undergoing GMD screening with method, which uses plasma glucose (fasting or non-fasting) HbA1c, was a Both cohorts were obtained from 6 hospitals across Catalonia, Spain, April 2020 2022. The primary outcome large age rate at...
El acretismo placentario ha aumentado debido al incremento de la cirugía uterina previa (en particular las cesáreas). La conducta evolucionado un abordaje quirúrgico radical a tratamiento conservador. Gestante 26,1 semanas que ingresó por rotura prematura membranas. A los 3 días se realizó una cesárea riesgo pérdida bienestar fetal apreciando placentario, dejando fragmento en el lecho cornual. Dada ausencia sangrado decidió adoptar expectante. control clínico posterior fue correcto. Los...
Abstract Objectives To develop gestational age-based reference ranges for cervical length in triplet pregnancies. The secondary objective was to assess the performance of measured between 18 and 20 + 6 days prediction preterm delivery before 28 32 weeks, respectively. Methods Observational retrospective study pregnancies three Spanish tertiary-care hospitals 2001 2019. Cervical measurements were consecutively obtained 15 34 weeks gestation. Pregnancies undergoing multifetal reduction or...
ABSTRACT Preeclampsia affects up to 4% of pregnancies and is marked by the development hypertension proteinuria after 20 weeks gestation. Complications associated with disorder include preterm birth, fetal growth restriction, placental abruption, HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome, seizures, other end organ damage. Aspirin has been shown reduce incidence preeclampsia 62%. However, it can also lead peripartum bleeding. Screening for in first trimester (11 13...
Objective: To examine baseline risk factors measured in the first-trimester screening for preeclampsia (PE) pregnant women with COVID-19 versus general population. compare among patients mild and severe COVID-19. Design: Observational retrospective study. Setting: Six maternities Catalonia. Population: Study were 231 undergoing PE positive SARS-CoV-2. Reference cohort 13,033 from 6 maternities. Methods: Recording of maternal history, mean arterial blood pressure (MAP), uterine artery...
<sec> <title>BACKGROUND</title> Fetal smallness affects 10% of pregnancies. These fetuses are at a higher risk adverse outcomes. Their management using estimated fetal weight (EFW) and feto-maternal Doppler has high sensitivity for outcomes; however, more than 60% electively delivered 37-38 weeks. On the other hand, classification angiogenic factors (AF) seems to have lower false positive rate. Here we present protocol GRAFD trial, which compares small term AF or Doppler. </sec>...