A5103163676- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Breast Cancer Treatment Studies
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Pregnancy and Medication Impact
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Blood Coagulation and Thrombosis Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Chronic Myeloid Leukemia Treatments
- Medical and Health Sciences Research
- Venous Thromboembolism Diagnosis and Management
- Prenatal Screening and Diagnostics
- Economic and Financial Impacts of Cancer
- Pregnancy-related medical research
- Estrogen and related hormone effects
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Lymphocytic Leukemia Research
- Advanced Breast Cancer Therapies
- Biomedical and Chemical Research
- Acute Myeloid Leukemia Research
- Gynecological conditions and treatments
Paracelsus Medical University
2015-2025
Klinikum Saarbrücken
2025
Paracelsus Medizinische Privatuniversität
2012-2024
Salzburger Landeskliniken
2012-2023
Tehran University of Medical Sciences
2023
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2012-2022
Universitätsklinikum Würzburg
2020-2022
Johannes Gutenberg University Mainz
2001-2019
University Hospital Heidelberg
2015-2019
Heidelberg University
2004-2019
Immune mechanisms and the renin–angiotensin system are implicated in preeclampsia. We investigated 25 preeclamptic patients compared them with 12 normotensive pregnant women 10 essential hypertension. Antibodies were detected by chronotropic responses to AT1 receptor–mediated stimulation of cultured neonatal rat cardiomyocytes coupled receptor-specific antagonists. Immunoglobulin from all stimulated receptor, whereas immunoglobulin controls had no effect. The increased autoimmune activity...
Preeclampsia is characterized by a marked increase in peripheral vascular resistance leading to an blood pressure, but the triggering mechanisms are unclear.To determine whether augmented sympathetic vasoconstrictor activity may be important mechanism mediating vasomotor tone, we measured postganglionic sympathetic-nerve vessels of skeletal muscle means intraneural microelectrodes nine women with preeclampsia, eight normotensive pregnant women, six nonpregnant and seven hypertension, both at...
Summary Women with a history of venous thromboembolism (VTE), thrombophilia or both may be at increased risk thrombosis during pregnancy, but the optimal management strategy is not well defined in clinical guidelines because limited trial data. A assessment and heparin prophylaxis was evaluated pregnant women VTE. In prospective (Efficacy Thromboprophylaxis as an Intervention Gravidity [EThIG]), 810 were assigned to one three strategies according pre-defined factors related VTE thrombophilic...
A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit questionable.To determine whether LMWH increases ongoing and live-birth rates in RPL.Controlled, multicenter trial randomization using minimization conducted from 2006 2013. (ClinicalTrials.gov: NCT00400387).14 university hospitals perinatal care centers Germany Austria.449 at least 2 consecutive early miscarriages or 1...
Abstract The majority of obstetrical clinics do not offer a trial labor after two Caesarean sections (TOLA2C) due to concerns about fetal and maternal complications such as uterine rupture or asphyxia. This study aimed establish delivery protocol for safely undergoing TOLA2C analyzed predictors successful vaginal delivery. Analysis retrospectively collected data all pregnant women consecutive was performed at the Obstetrics Department tertiary community hospital from January 2013 until...
Preeclampsia has been shown to constitute a state of sympathetic overactivity. However, it remains unclear if the activity precedes preeclampsia or represents only secondary phenomenon. To further investigate this issue, we performed prospective study in pregnant women considered be at increased risk for owing during preceding pregnancy.Twenty-two with history were longitudinally studied on three occasions: twice pregnancy (M1: 22 +/- 4, M2: 33 5 weeks) and once postpartum (M3: 26 6 weeks...
Abstract Objective Decreased fetal heart rate variability is associated with higher perinatal morbidity and mortality in intrauterine growth restriction (IUGR). This study used a new method [phase‐rectified signal averaging (PRSA)] to calculate acceleration‐ deceleration‐related fluctuations of the rate. Method Cardiotocograms from 74 growth‐restricted 161 normal fetuses were included. Both groups matched for gestational age. The transformed PRSA was quantified by acceleration‐related...
A long-term analysis by the Early Breast Cancer Trialist Group (EBCTG) revealed a strong correlation between local control and cancer-specific mortality. MicroRNAs (miRs), short (20–25 nucleotides) non-coding RNAs, have been described as prognosticators predictors for breast cancer in recent years. The aim of current study was to identify miRs that can predict after conserving therapy (BCT) early stage cancer. Clinical data 46 patients with relapse BCT were selected from institutional...
Abstract Background Sexuality in Inflammatory bowel disease (IBD) is often a tabu topic. But do patients want to talk about it at all? How familiar are IBD Nurses and MD with this topic, will routinely be addressed IBD-patients during their consultations? This study attempted determine the need for information willingness sexuality among patients, nurses MDs. The survey was carried out an outpatient setting Germany. Methods Each participant completed anonymous questionnaire, limited 2 MDs,...
Vaginal delivery in cases of breech presentation is considered potentially stressful for the newborn. The maternal upright position may represent a more physiological approach to facilitating birth. We compare safety and efficacy two positions vaginal delivery. A prospective, single-center, observational cohort study from October 2006 January 2021 high-level obstetric center, Salzburg, Austria. deliveries all-fours (n = 140) were compared with those assisted supine 92). primary outcome...
Pooled human platelet lysate (pHPL) is an efficient alternative to xenogenic supplements for ex vivo expansion of mesenchymal stem cells (MSCs) in clinical studies. Currently, porcine heparin used pHPL-supplemented medium prevent clotting due plasmatic coagulation factors. We therefore searched and reproducible preparation method that avoids clot formation while omitting animal-derived heparin. established a protocol deplete fibrinogen by pHPL medium, subsequent mechanical hydrogel...
Abstract Objective: Vaginal delivery of fetal breech presentation is considered to be a challenge for obstetricians. The purpose this study was show that vaginal in all fours position feasible and safe mother child compared with classic support. Methods: A single-center prospective observational case series (n=41) retrospective cohort deliveries the form matched-pair analysis. Results: Deliveries successfully took place without obstetric intervention 70.7% (n=29/41), those including 90.2%...
In order to investigate the effect of different immunosuppressive regimens and time interval between transplantation pregnancy on long-term outcome, we performed a case-control study in pregnant renal allograft recipients. Eighty-one pregnancies kidney transplanted recipients were identified [cyclosporine (CYA): n = 40; azathioprine (AZA): 41]. Controls matched with respect important prognostic factors. Posttransplant follow-up was 91.3 +/- 5 months. Graft patient survival similar both...
To evaluate retrospectively rates of local (LCR) and locoregional tumor control (LRCR) in patients with locally advanced breast cancer (LABC) who were treated preoperative chemotherapy (primary systemic treatment, PST) followed by breast‐conserving surgery (BCS) either intraoperative radiotherapy electrons (IOERT) preceding whole‐breast irradiation (WBI) (Group 1) or WBI an external bed boost (electrons photons) instead IOERT 2). From 2002 to 2007, 83 clinical Stage II III enrolled Group 1...
The new expert recommendation from the Austrian Society of Obstetrics and Gynaecology (OEGGG) comprises an interpretation summary guidelines leading specialist organisations worldwide (RCOG, ACOG, SOGC, CNGOF, WHO, NIH, NICE, UpToDate). In essence it outlines alternatives to direct pathway elective repeat caesarean section (ERCS). so doing aligns with international trends, according which a differentiated, individualised clinical approach is recommended that considers benefits risks both...
As the accurate diagnosis and treatment of gestational diabetes mellitus (GDM) is increasing importance; new diagnostic approaches for assessment GDM in early pregnancy were recently suggested. We evaluate power an 'early' oral glucose tolerance test (OGTT) 75 g glycosylated fibronectin (glyFn) screening a normal cohort.In prospective cohort study, 748 singleton pregnancies are recruited 6 centres Switzerland, Austria Germany. Women screened pre-existing by OGTT and/or biomarker, glyFn, at...
AbstractObjective: We investigated the hypothesis that changes in blood flow uteroplacental and fetoplacental circulation preeclampsia are associated with an abnormality of placental or uterine bed nitric oxide (NO) synthesis.Methods: measured pulsatility indices on Doppler waveform analysis from umbilical arteries 20 patients 14 healthy pregnant controls before elective cesarean section. During section, biopsies placenta were taken synthase (NOS) activity was by [3H] L-arginine-[3H]...