Gerd Fastner

ORCID: 0000-0002-7951-1246
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About
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Research Areas
  • Breast Cancer Treatment Studies
  • Advanced Radiotherapy Techniques
  • Lung Cancer Diagnosis and Treatment
  • Breast Lesions and Carcinomas
  • Brain Metastases and Treatment
  • Cancer Genomics and Diagnostics
  • Breast Implant and Reconstruction
  • MicroRNA in disease regulation
  • Radiomics and Machine Learning in Medical Imaging
  • Medical Imaging Techniques and Applications
  • Cancer Cells and Metastasis
  • Radiation Effects and Dosimetry
  • Advances in Oncology and Radiotherapy
  • Radiopharmaceutical Chemistry and Applications
  • Lung Cancer Research Studies
  • Meningioma and schwannoma management
  • Glioma Diagnosis and Treatment
  • Head and Neck Surgical Oncology
  • Colorectal Cancer Surgical Treatments
  • BRCA gene mutations in cancer
  • Lung Cancer Treatments and Mutations
  • Esophageal Cancer Research and Treatment
  • Cancer Treatment and Pharmacology
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Advanced biosensing and bioanalysis techniques

Paracelsus Medical University
2016-2025

University of Milan
2023

Dana-Farber Cancer Institute
2023

European Institute of Oncology
2023

Salzburger Landeskliniken
2002-2022

Paracelsus Medizinische Privatuniversität
2014-2022

Medical Cañada (Spain)
2020

Universitätsklinik für Strahlentherapie
2020

Government of the Republic of Korea
2020

University of Salzburg
2015

The 18th St Gallen International Breast Cancer Conference held in March 2023, Vienna, Austria, assessed significant new findings for local and systemic therapies early breast cancer with a focus on the evaluation of multimodal treatment options. emergence more effective, innovative agents both preoperative (primary or neoadjuvant) post-operative (adjuvant) settings has underscored pivotal role multidisciplinary approach decision making, particularly when selecting therapy an individual...

10.1016/j.annonc.2023.08.017 article EN cc-by-nc-nd Annals of Oncology 2023-09-06

The aim of the present paper is to update practical guidelines for postoperative adjuvant radiotherapy breast cancer published in 2007 by expert panel German Society Radiooncology (Deutsche Gesellschaft für Radioonkologie, DEGRO). recommendations are based on a revision interdisciplinary S-3 July 2012. A comprehensive survey literature concerning following conserving therapy (BCT) was performed using search terms "breast cancer", "radiotherapy", and therapy". Data from lately meta-analyses,...

10.1007/s00066-013-0437-8 article EN cc-by Strahlentherapie und Onkologie 2013-09-03

For quantitative microRNA analyses in formalin-fixed paraffin-embedded (FFPE) tissue, expression levels have to be normalized endogenous controls. To investigate the most stably-expressed microRNAs breast cancer and its surrounding we used tumor samples from primary tumors metastatic sites. MiRNA profiling using TaqMan(®) Array Human MicroRNA Cards, enabling quantification of 754 unique human miRNAs, was performed FFPE specimens 58 patients with cancer. Forty-two (72%) were collected 16...

10.3390/ijms17020156 article EN cc-by International Journal of Molecular Sciences 2016-01-26

Peroxisome proliferator–activated receptor-γ coactivator-1 (PPARGC1) is a transcriptional coactivator that has been implicated in the regulation of genes involved energy metabolism. We studied associations two polymorphisms identified PPARGC1 transcripts with obesity indices 591 middle-aged men and 467 women cross-sectional Austrian population. Because neither polymorphic site was likely to be functional site, we analyzed sex-specific loci haplotype combinations indices. Significant BMI (P =...

10.2337/diabetes.51.4.1281 article EN Diabetes 2002-04-01

Two randomized intraoperative radiation therapy trials for early-stage breast cancer were recently published. The ELIOT Trial used electrons (IOERT), and the TARGIT-A Update 50-kV X-rays (IORT). These studies compared similarities differences. results analyzed to determine which patients might be suitable single-dose treatment.The primary sources of data Trial, as well a comprehensive analysis peer-reviewed literature accelerated partial irradiation (APBI) using or electrons. Studies...

10.1245/s10434-014-3999-5 article EN cc-by Annals of Surgical Oncology 2014-08-19

A long-term analysis by the Early Breast Cancer Trialist Group (EBCTG) revealed a strong correlation between local control and cancer-specific mortality. MicroRNAs (miRs), short (20–25 nucleotides) non-coding RNAs, have been described as prognosticators predictors for breast cancer in recent years. The aim of current study was to identify miRs that can predict after conserving therapy (BCT) early stage cancer. Clinical data 46 patients with relapse BCT were selected from institutional...

10.1186/s13148-016-0198-1 article EN cc-by Clinical Epigenetics 2016-03-08

Artificial Intelligence (AI) applications are increasingly prevalent in radiotherapy, including commercial software solutions for automatic segmentation of anatomical structures 3D Computed Tomography (CT). However, their use intraoperative electron radiotherapy (IOERT) remains limited. In particular, no AI solution is available contouring cone beam CT (CBCT) images acquired with a mobile CBCT device. The U-Net convolutional neural network architecture has gained huge success medical image...

10.3390/cancers17030485 article EN Cancers 2025-02-01

Two randomized intraoperative radiation therapy trials for early-stage breast cancer were recently published. The ELIOT Trial used electrons (IOERT), and the TARGIT-A Update 50-kV X-rays (IORT). These studies compared similarities differences. results analyzed to determine which patients might be suitable single-dose treatment. primary sources of data Trial, as well a comprehensive analysis peer-reviewed literature accelerated partial irradiation (APBI) using or electrons. Studies published...

10.1245/s10434-014-3998-6 article EN cc-by Annals of Surgical Oncology 2014-08-26

To evaluate retrospectively rates of local (LCR) and locoregional tumor control (LRCR) in patients with locally advanced breast cancer (LABC) who were treated preoperative chemotherapy (primary systemic treatment, PST) followed by breast‐conserving surgery (BCS) either intraoperative radiotherapy electrons (IOERT) preceding whole‐breast irradiation (WBI) (Group 1) or WBI an external bed boost (electrons photons) instead IOERT 2). From 2002 to 2007, 83 clinical Stage II III enrolled Group 1...

10.1002/ijc.29064 article EN International Journal of Cancer 2014-07-04
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