A5024457348- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Electrolyte and hormonal disorders
- Kawasaki Disease and Coronary Complications
- Renal Diseases and Glomerulopathies
- Ion Transport and Channel Regulation
- Estrogen and related hormone effects
- Vasculitis and related conditions
- Immune Response and Inflammation
- Particle accelerators and beam dynamics
- Drug Transport and Resistance Mechanisms
- Viral Infections and Immunology Research
- Particle Accelerators and Free-Electron Lasers
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Influenza Virus Research Studies
- Cardiovascular Function and Risk Factors
- Pharmacological Effects and Toxicity Studies
- Mechanical Circulatory Support Devices
- Adipose Tissue and Metabolism
- Systemic Lupus Erythematosus Research
- Infectious Encephalopathies and Encephalitis
- Renal function and acid-base balance
- Immunodeficiency and Autoimmune Disorders
Nakamura Memorial Hospital
2008-2025
University of Toyama
2015-2024
University of Milan
2023
Dana-Farber Cancer Institute
2023
European Institute of Oncology
2023
Hamamatsu Medical Center
2006-2022
Tateyama Elementary School
2022
Showa University Northern Yokohama Hospital
2022
Niigata University
2003-2021
University of Chicago
2021
The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel reviewed and endorsed substantial new evidence on aspects of the local regional therapies for early breast cancer, supporting less extensive surgery to axilla shorter durations radiation therapy. It refined its earlier approach classification management luminal disease in absence amplification or overexpression Human Epidermal growth factor Receptor 2 (HER2) oncogene, while retaining essentially unchanged...
<h2>ABSTRACT</h2> The 14th St Gallen International Breast Cancer Conference (2015) reviewed substantial new evidence on locoregional and systemic therapies for early breast cancer. Further experience has supported the adequacy of tumor margins defined as ‘no ink invasive or DCIS' safety omitting axillary dissection in specific cohorts. Radiotherapy trials support irradiation regional nodes node-positive disease. Considering subdivisions within luminal disease, Panel was more concerned with...
Purpose To investigate the efficacy and safety of zoledronic acid for treatment bone metastases from breast cancer. Patients Methods Women with (N = 228) were randomly assigned to receive 4 mg (n 114) or placebo via 15-minute infusions every weeks 1 year. The primary end point was skeletal-related event (SRE) rate ratio between groups. An SRE defined as pathologic fracture, spinal cord compression, radiation surgery bone. Secondary points included percentage patients at least one SRE,...
We have identified and characterized a novel human estrogen receptor (ER) β isoform, ERβcx, which is truncated at the C-terminal region but has an extra 26 amino acids due to alternative splicing. The ERβcx transcript expressed in testis, ovary, thymus prostate as well cultured cell lines such HEC-1, HOS-TE85 Saos-2 cells. protein also immunodetectable these Biochemical analysis reveals that average dissociation constants ( K d) of ERα ERβ for 17β-estradiol (E 2 ) are 0.2 0.6 nM...
Background— The metabolic syndrome consists of a cluster atherosclerotic risk factors, many which also have been implicated in the genesis atrial fibrillation (AF). However, precise role development AF is unknown. Methods and Results— This prospective, community-based, observational cohort study was based on an annual health check-up program Japan. We studied 28 449 participants without baseline AF. used 2 different criteria for syndrome—the guidelines National Cholesterol Education Program...
The 18th St Gallen International Breast Cancer Conference held in March 2023, Vienna, Austria, assessed significant new findings for local and systemic therapies early breast cancer with a focus on the evaluation of multimodal treatment options. emergence more effective, innovative agents both preoperative (primary or neoadjuvant) post-operative (adjuvant) settings has underscored pivotal role multidisciplinary approach decision making, particularly when selecting therapy an individual...
Proton NMR analyses have been made to elucidate the conformational characteristics of modified nucleotides as found in first position anticodon tRNA [derivatives 5-methyl-2-thiouridine 5'-monophosphate (pxm5s2U) and derivatives 5-hydroxyuridine (pxo5U)]. In pxm5s2U, C3'-endo form is extraordinarily more stable than C2'-endo for ribose ring, because combined effects 2-thiocarbonyl group 5-substituent. By contrast, pxo5U, much form, interaction between 5-substituent 5'-phosphate group. The...
In order to investigate the localization of estrogen receptor (ER) alpha and ERbeta in reproductive organs rat, polyclonal antibodies were raised each specific amino acid sequence. The Western blot with anti-ERalpha antibody showed a 66 kDa band rat ovary uterus, while that anti-ERbeta detected 55 ovary, uterus prostate. ligand-independent nuclear two receptors was verified by immunocytochemistry. By immunohistochemistry, nuclei glandular luminal epithelial cells stained antibody, whereas...
Saccharomyces cerevisiae GSC1 (also called FKS1) and GSC2 FKS2) have been identified as the genes for putative catalytic subunits of beta-1,3-glucan synthase. We cloned three Candida albicans genes, GSC1, GSL1, GSL2, that significant sequence homologies with S. GSC1/FKS1, GSC2/FKS2, recently FKSA Aspergillus nidulans at both nucleotide amino acid levels. Like Gsc/Fks proteins, none predicted products C. or GSL2 displayed obvious signal sequences their N-terminal ends, but each product...
Purpose The primary aim of this study was to compare the effectiveness oral uracil-tegafur (UFT) with that classical cyclophosphamide, methotrexate, and fluorouracil (CMF) given as postoperative adjuvant treatment women node-negative, high-risk breast cancer. Patients Methods Women cancer were randomly assigned receive either 2 years UFT or six cycles CMF after surgery. end point relapse-free survival (RFS). Overall (OS), toxicity, quality life (QOL) secondary points. hypothesis not inferior...
Normal rat hepatocytes maintained on tissue culture plastic and in serum-supplemented medium lose their gap junctions within 12 hr expression of tissue-specific functions 24 to 72 hr. The are lost via internalization degradation, the differentiated due loss synthesis rapid degradation mRNAs. Near normal levels mRNAs can be achieved by stabilization but not transcription (for most genes), if cells cultured a serum-free, hormonally defined substrata plastic, fibronectin or laminin, various...
1. Intravenous (I.V.) injection of human recombinant interleukin‐1 alpha (IL‐1 alpha) produced dose‐dependent monophasic fevers in rats. Moreover, the I.V. IL‐1 rises plasma concentrations adrenocorticotrophic hormone (ACTH) 30 min after injections with dosages 5 micrograms/kg and 15 alpha. 2. The febrile responses induced by (15 micrograms/kg) were completely abolished, conversely hypothermia occurred, when animals pre‐treated a cyclo‐oxygenase inhibitor, indomethacin (INDO). Pre‐treatment...