Sara Y. Brucker
A5023008141- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- HER2/EGFR in Cancer Research
- Endometriosis Research and Treatment
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- BRCA gene mutations in cancer
- Pelvic floor disorders treatments
- Reproductive System and Pregnancy
- Global Cancer Incidence and Screening
- Female Genital Mutilation/Cutting Issues
- Pregnancy and preeclampsia studies
- Cancer survivorship and care
- Clinical practice guidelines implementation
- Health and Medical Studies
- Estrogen and related hormone effects
- Radiomics and Machine Learning in Medical Imaging
- Ureteral procedures and complications
- Sexual Differentiation and Disorders
University of Tübingen
2016-2025
University Children's Hospital Tübingen
2016-2025
Institut für Frauengesundheit
2015-2024
Universitätsklinikum Tübingen
2015-2024
Universitäts Frauenklinik
2014-2024
TH Bingen University of Applied Sciences
2024
European Institute of Oncology
2023
University of Milan
2023
Dana-Farber Cancer Institute
2023
Universität Ulm
2023
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
STUDY QUESTIONWhat classification system is more suitable for the accurate, clear, simple and related to clinical management categorization of female genital anomalies?
Although unequivocal evidence has shown the prognostic relevance of circulating tumor cells (CTC) in peripheral blood patients with metastatic breast cancer, less is available for CTCs at time primary diagnosis.We conducted a pooled analysis individual data from 3,173 nonmetastatic (stage I-III) cancer five institutions. The prevalence and numbers were assessed diagnosis FDA-cleared CellSearch System (Janssen Diagnostics, LLC). Patient outcomes analyzed using meta-analytic procedures,...
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
Although apoptosis and necrosis have distinct features, the identification discrimination of apoptotic necrotic cell death in vitro is challenging. Immunocytological biochemical assays represent current gold standard for monitoring pathways; however, these are invasive, render large numbers cells impede continuous experiments. In this study, both room temperature (RT)-induced heat-triggered were analyzed individual Saos-2 SW-1353 by utilizing Raman microspectroscopy. A targeted analysis...
The new ESHRE/ESGE classification system of female genital anomalies is presented, aiming to provide a more suitable for the accurate, clear, correlated with clinical management and simple categorization anomalies. Congenital malformations tract are common miscellaneous deviations from normal anatomy health reproductive consequences. Until now, three systems have been proposed their categorization, but all them associated serious limitations. European Society Human Reproduction Embryology...
The 18th St Gallen International Breast Cancer Conference held in March 2023, Vienna, Austria, assessed significant new findings for local and systemic therapies early breast cancer with a focus on the evaluation of multimodal treatment options. emergence more effective, innovative agents both preoperative (primary or neoadjuvant) post-operative (adjuvant) settings has underscored pivotal role multidisciplinary approach decision making, particularly when selecting therapy an individual...
Uterus transplantation (UTx) is a novel type of to treat infertility in women with an absent or nonfunctioning uterus. The International Society Transplantation (ISUTx) has developed registry monitor worldwide UTx activities while serving as repository for specific research questions.The web-based separate data fields donor, recipient, surgeries, immunosuppression, rejections, pregnancies live birth(s), and transplant hysterectomies. Data are prospectively registered.A total 45 procedures...
The Mayer-Rokitansky-Kuester-Hauser (MRKH) syndrome is a malformation of the female genitals (occurring in one 4000 live births) as result interrupted embryonic development Müllerian (paramesonephric) ducts. This retrospective study examined issue associated malformations, subtyping, and frequency distribution subtypes MRKH syndrome.Fifty-three patients were investigated using newly developed standardized questionnaire. Together with results clinical diagnostic examinations, classified into...
Adenomyosis is an important clinical challenge in gynecology and healthcare economics; its fully developed form, hysterectomy often used to treat it premenopausal perimenopausal women. Symptoms of adenomyosis typically include menorrhagia, pelvic pain dysmenorrhea. Moreover, leiomyomas commonly coexist the same uterus, differentiating symptoms for each pathological process can be problematic. Although has been recognized over a century, reliable epidemiological studies on this condition are...
To examine the efficacy of biweekly hyperimmunoglobulin (HIG) administration to prevent maternal-fetal transmission cytomegalovirus (CMV) in women with primary first-trimester CMV infection.This was a prospective observational study confirmed infection first trimester who had HIG at or before 14 weeks' gestation. All treatment until 20 gestation dose 200 IU/kg maternal body weight. Each subject underwent amniocentesis least 6 weeks after presentation about weeks. Primary outcome time...
<h3>Background</h3> Congenital malformations involving the Müllerian ducts are observed in around 5% of infertile women. Complete aplasia uterus, cervix, and upper vagina, also termed or Mayer–Rokitansky–Kuster–Hauser (MRKH) syndrome, occurs with an incidence 1 4500 female births, both isolated syndromic forms. Previous reports have suggested that a proportion cases, especially caused by variation copy number at different genomic loci. <h3>Methods</h3> In order to obtain overview...
What is the recommended diagnostic work-up of female genital anomalies according to European Society Human Reproduction and Embryology (ESHRE)/European for Gynaecological Endoscopy (ESGE) system? The ESHRE/ESGE consensus diagnosis presented. Accurate congenital still remains a clinical challenge due drawbacks previous classification systems non-systematic use methods with varying accuracy, some them quite inaccurate. Currently, wide range non-invasive procedures are available, enriching...
Progress has been made in the treatment of metastatic breast cancer recent decades, but very few therapies use patient or tumor-specific characteristics to tailor individualized treatment. More than ten years after publication reference human genome sequence, analysis methods have improved enormously, fostering hope that biomarkers can be used individualize and offer precise based on tumor characteristics. Biomarkers at every level system (genetics, epigenetics, gene expression, micro-RNA,...