Linda E. Kelemen
A5022874436- Ovarian cancer diagnosis and treatment
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Endometrial and Cervical Cancer Treatments
- Virus-based gene therapy research
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Ferroptosis and cancer prognosis
- CRISPR and Genetic Engineering
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Endometriosis Research and Treatment
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Microtubule and mitosis dynamics
- Health, Environment, Cognitive Aging
- RNA Research and Splicing
- Mitochondrial Function and Pathology
South Carolina Department of Health and Environmental Control
2021-2024
Alberta Health Services
2010-2023
UNSW Sydney
2023
The University of Melbourne
2023
Medical University of South Carolina
2014-2022
MUSC Hollings Cancer Center
2014-2022
University of British Columbia
2013-2021
University of Calgary
2010-2021
College of Charleston
2016
University of Southern California
2011-2016
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Abstract Obesity and adult weight gain are well-established risk factors for postmenopausal breast cancer. Although there a few studies demonstrating the contribution of to cancer risk, whether during critical time period is specifically associated with or subsequent loss among women who have gained will reduce excess not firmly established. We investigated association changes in (loss 5% body weight) using two factor models: (a) age 18 30 years menopause (b) after baseline study 1986 on...
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
There are 5 major histotypes of ovarian carcinomas. Diagnostic typing criteria have evolved over time, and past cohorts may be misclassified by current standards. Our objective was to reclassify the recently assembled Canadian Ovarian Experimental Unified Resource Alberta Tumor Type using immunohistochemical (IHC) biomarkers develop an IHC algorithm for carcinoma histotyping. A total 1626 samples from were subjected a reclassification comparing original with predicted histotype. Histotype...
Some weight loss diets promote protein intake; however, the association of with disease is unclear. In 1986, 29,017 postmenopausal Iowa women without cancer, coronary heart (CHD), or diabetes were followed prospectively for 15 years cancer incidence and mortality from CHD, all causes. Mailed questionnaires assessed dietary, lifestyle, medical information. Nutrient density models estimated risk ratios a simulated substitution total type dietary carbohydrate vegetable animal protein. The...
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing serous leading us to hypothesize that variation this gene differentially associates with cancer risk according histological subtype. Here comprehensively map respect analyse DNA methylation expression profiles across subtypes. Different single-nucleotide polymorphisms associate invasive (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) (rs11651755 OR=0.77, P=1.6 10−8) cancer. Risk alleles for...
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized the 3′ untranslated region at putative microRNA (miRNA)-binding sites represent functional targets influence EOC susceptibility. Here, we evaluate association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and risk 18,174 cases 26,134 controls from 43 studies genotyped through...
Aims Lynch syndrome screening in ovarian carcinoma is controversial. The aim of this study was to assess the frequency deficient mismatch repair ( dMMR ) protein a retrospective cohort enriched for non‐high‐grade serous carcinomas and its association with outcome within histological types. Methods results Tissue microarrays representing 612 were tested proteins MLH 1, PMS 2, MSH 6) by immunohistochemistry. detected 13.8% endometrioid 2.4% clear cell carcinomas, but not other Within 11 25...
Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents causal effect, or holds for all histological subtypes. The lack of observed serous cancers may, instance, be due disease-associated weight loss. Mendelian randomization (MR) uses genetic markers proxies risk factors overcome limitations observational studies. We used MR elucidate the relationship BMI cancer, hypothesizing...
Mammographic density is a strong risk factor for breast cancer, yet few studies have evaluated trends, and associated factors, over time. The authors retrieved digitized mammograms (> or =1 per woman) imaged in 1990-2003 to evaluate percent (PD) the Minnesota Breast Cancer Family cohort. Multivariable-adjusted, mixed-effects, repeated-measures models incorporating natural cubic spline provided estimates of nonlinear trends PD with age were used examine association covariates. Overall, 5,698...
Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies OvCa show mixed results and require better understanding prognostic relevance FOLR1 expression. We conducted a large study evaluating expression with survival different histological types OvCa. Tissue microarrays composed tumour samples from 2801 patients Ovarian Tumour Analysis (OTTA) consortium were assessed...
Abstract We aimed to validate the prognostic association of p16 expression in ovarian high‐grade serous carcinomas (HGSC) and explore it other carcinoma histotypes. protein was assessed by clinical‐grade immunohistochemistry 6525 including 4334 HGSC using tissue microarrays from 24 studies participating Ovarian Tumor Tissue Analysis consortium. patterns were interpreted as abnormal (either overexpression referred block or absence) normal (heterogeneous). CDKN2A (which encodes p16) mRNA also...
Ovarian carcinoma is composed of five major histologic types, which associate with outcome and predict therapeutic response. Our aim was to evaluate type assessments across the centers participating in Tumor Tissue Analysis (OTTA) consortium using an immunohistochemical (IHC) prediction model.Tissue microarrays (TMA) clinical data were available for 524 pathologically confirmed ovarian carcinomas. Centralized IHC conducted ARID1A, CDKN2A, DKK1, HNF1B, MDM2, PGR, TP53, TFF3, VIM, WT1, three...
PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade (LGSOC)). We aimed to characterise expression as biomarker epithelial large population-based study.
Dysfunction in enzymes involved one-carbon (1-C) metabolism can lead to increased chromosomal strand breaking and abnormal methylation patterns, which are both associated with cancer risk. Availability of 1-C units may modify We investigated the association single-nucleotide polymorphisms (SNP) 21 genes transfer pathway among 829 Caucasian cases primary epithelial ovarian 941 frequency-matched unaffected controls enrolled at Mayo Clinic (Rochester, MN) Duke University (Durham, NC) examined...