A5102986481- Reproductive Biology and Fertility
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Renal and related cancers
- Epigenetics and DNA Methylation
- Digital Radiography and Breast Imaging
- Cystic Fibrosis Research Advances
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Cognitive Abilities and Testing
- Plant Molecular Biology Research
- Genetic and Kidney Cyst Diseases
- Urological Disorders and Treatments
- Microtubule and mitosis dynamics
- Blood Pressure and Hypertension Studies
- Amino Acid Enzymes and Metabolism
- Pediatric Urology and Nephrology Studies
- Sperm and Testicular Function
- Birth, Development, and Health
- Global Cancer Incidence and Screening
- Nutrition, Genetics, and Disease
- Reproductive System and Pregnancy
Linyi People's Hospital
2016-2024
Shandong University
2023
Mayo Clinic
2008
Mammographic density is a strong risk factor for breast cancer, yet few studies have evaluated trends, and associated factors, over time. The authors retrieved digitized mammograms (> or =1 per woman) imaged in 1990-2003 to evaluate percent (PD) the Minnesota Breast Cancer Family cohort. Multivariable-adjusted, mixed-effects, repeated-measures models incorporating natural cubic spline provided estimates of nonlinear trends PD with age were used examine association covariates. Overall, 5,698...
Tubulin beta eight class VIII (TUBB8) is a subtype of β-tubulin that only exists in primates. Mutations the TUBB8 gene have been proven to cause oocyte maturation arrest. The aim this study was identify new types mutations TUBB8. Six women (families) with arrest and 100 healthy controls were recruited. sequence amplified analyzed by Sanger sequencing, which revealed de novo heterozygous variant c.292G > A (p.G98R) one affected individual. This absent fertile females predicted be highly...
Abstract Context Obesity management prior to infertility treatment remains a challenge. To date, results from randomized clinical trials involving weight loss by lifestyle interventions have shown no evidence of improved live birth rate. Objective This work aimed determine whether pharmacologic weight-loss intervention before in vitro fertilization and embryo transfer (IVF-ET) can improve rate among overweight or obese women. Methods We conducted randomized, double-blinded,...
The genetic basis of fertilization failure after intracytoplasmic sperm injection (ICSI) is largely unknown and the aim this study to investigate causes in primary infertile women.Six affected women diagnosed with infertility were recruited. genetically pathogenic factor their failures investigated by clinical exome sequencing. One hundred healthy controls verified Sanger sequencing.Novel compound heterozygous mutations c.625G > T c.759-2A G WEE2 one individual revealed Trios analysis...
To evaluate the effect of dehydroepiandrosterone (DHEA) pre-treatment before in vitro fertilization and embryo transfer (IVF-ET) on live birth rate infertile women with poor ovarian response (POR) defined according to Bologna criteria.A randomized, double-blind, placebo-controlled trial.Nine reproductive medical centers China.A total 821 participants POR criteria were enrolled study between April 2016 December 2018.Eligible randomly assigned receive either DHEA (n = 410) or placebo 411)...
The aim of the present study was to determine whether size zona pellucida (ZP) thinning area by laser-assisted hatching affected potential development vitrified-warmed embryos. A total 196 cleavage-stage embryos (from 49 patients, four sister per patient) were used in study, i.e., from each patient randomly assigned groups: a control group that not zona-manipulated (zona intact, A); one experimental which quarter thinned using ZP (group B); second half C); and third two-thirds D). Subsequent...
The aim of the present study was to evaluate influence a gonadotropin-releasing hormone (GnRH) antagonist compared with GnRH agonist on in vitro fertilization (IVF) cycle outcome reproductive women. characteristics treatment and outcomes pregnancy were retrospectively between (GnRH-A, group) (GnRH-a, regimens. area under curve (AUC) receiver operating characteristic (ROC) curves also used whether endometrial thickness (cm), progesterone (P) level (ng/ml) estradiol (E2) (pg/ml) day human...
The aim of the present study was to evaluate factors that affect success rate gonadotropin-releasing hormone antagonist on in vitro fertilization/intracytoplasmic sperm injection cycles. Multivariate analysis performed assess influence outcomes, such as oocytes retrieved, and pregnancy. results showed E2, P human chorionic gonadotropin (HCG) day body mass index (BMI) were positively correlated with number retrieved (P=0.001, P=0.024, P=0.017, respectively). duration infertility well...
Background: Renal agenesis (RA) is one of the most severe congenital anomalies kidney and urinary tract; it known to be highly genetically heterogeneous. The purpose this study was explore clinical significance genetic diagnostics in a Chinese RA family. Methods: Five members an family 100 healthy people were recruited. Clinical exome sequencing conducted underlying cause affected Results: Exome identified novel missense mutation (c.2333T>A, p.Val778Asp) GREB1L gene. This variant not...
The genetic basis of empty follicle syndrome (EFS) is largely unknown, and the aim this study was to investigate causes EFS in primary infertile women.Four affected women diagnosed with anovulation were recruited, whole exome sequencing (WES) requested for diagnosis cases. One hundred healthy controls verified by Sanger sequencing.A novel homozygous variant LHCGR gene (NM_000233:c.1847C>A) revealed one individual WES. Trios analysis mutation an autosomal recessive pattern. This absent 100...
The aim of the present study was to evaluate influence a gonadotropin-releasing hormone (GnRH) antagonist compared with GnRH agonist on in vitro fertilization cycle outcome patients polycystic ovary syndrome. outcomes pregnancy were evaluated. area under curve (AUC) receiver operating characteristic (ROC) also used whether endometrial thickness (cm) and estradiol (E2) level (pg/ml) day human chorionic gonadotropin (hCG) administration (the hCG day) had best sensitivity specificity for...
Background: Dynein, axonemal, heavy chain 1 (DNAH1) gene mutations have been found to be related primary ciliary dyskinesia (PCD) and the DNAH1 is associated with abnormal flagellar morphology in spermatozoa. Infertility a common condition women presenting ovarian insufficiency (POI) characterized by hypergonadotropic hypogonadism. The purpose of this study was explore clinical significance genetic diagnostics several Chinese infertile atypical POI. Methods: Four POI patients 100 healthy...
To analyze the difference in gene expression, amino acid and carnitine levels cervical secretions between endometria of pre-receptive receptive stages, with an aim to provide clues for identifying new molecular markers endometrial receptivity.Fifty nine infertile women treated at Department Reproductive Medicine Linyi People's Hospital from January 6, 2020 31, 2022 were selected as study subjects, which matched 3 pairs (6 cases) preparing embryo transfer based on factors such age, body mass...
To assess the association of gene expression with development potential early embryos derived from patients polycystic ovary syndrome (PCOS).Three pairs infertile respectively matched age, body mass index, ovarian reserve and treatment gonadotrophin-releasing hormone (GnRH) antagonists were selected. Patients fewer assigned as case group (n = 3), whilst remainders control 3). Ovarian granulosa cells collected for extraction total RNA subjected to sequencing. The results differential...