A5054280328- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Effects and risks of endocrine disrupting chemicals
- Circular RNAs in diseases
- Reproductive Health and Technologies
- Heavy Metal Exposure and Toxicity
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Sperm and Testicular Function
- Per- and polyfluoroalkyl substances research
- Reproductive System and Pregnancy
- Renal cell carcinoma treatment
- Birth, Development, and Health
- Renal and related cancers
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Infection Control in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Smoking Behavior and Cessation
- Microbial Inactivation Methods
- Prostate Cancer Treatment and Research
Capital Medical University
2023-2025
Peking University
2015-2024
Nanjing Medical University
2024
Second Affiliated Hospital of Zhejiang University
2009-2024
Peking University People's Hospital
2015-2024
Beijing Chao-Yang Hospital
2023-2024
Nanjing University
2015-2023
Mayo Clinic Hospital
2023
Chongqing Maternal and Child Health Hospital
2021
Faculty of Public Health
2020
Circular RNAs (circRNAs) are a novel class of endogenous noncoding formed by covalently closed loop, and increasing evidence has revealed that circRNAs play crucial functions in regulating gene expression. CircSLC8A1 is circRNA generated from the SLC8A1 gene. Currently, role underlying molecular mechanisms circSLC8A1 bladder cancer remain unknown.The differentially expressed were identified RNA-sequencing data, was determined as new candidate circRNA. qRT-PCR used to detect expression...
Abstract Urinary bladder cancer (UBC) patients at muscle invasive stage have poor clinical outcome, due to high propensity for metastasis. Cancer-associated fibroblasts (CAFs), one of the principal constituents tumor stroma, play an important role in development. However, it is unclear whether CAFs from UBC induce cell invasion and which signaling pathway involved. Herein, we found that conditional medium (CAF-CM) enhanced cells. CAF-CM induced epithelial-mesenchymal transition (EMT) by...
High tumor recurrence is frequently observed in patients with urinary bladder cancers (UBCs), the need for biomarkers of prognosis and drug response.Chemoresistance subsequent are driven by a subpopulation initiating cells, namely cancer stem-like cells (CSCs).However, underlying molecular mechanism chemotherapy-induced CSCs enrichment remains largely unclear.In this study, we found that during gemcitabine treatment lncRNA-Low Expression Tumor (lncRNA-LET) was downregulated chemoresistant...
This study aims to examine the impact of insulin resistance (IR) on risk spontaneous abortion in patients who received infertility treatment.This is a cohort 107 achieved their first pregnancy after treatment tertiary medical center. A homeostasis model assessment IR (HOMA-IR) was carried out. Patient demographic characteristics and outcome were also recorded. Statistical comparison made between with without IR. Logistical regression analysis used assess effect several other factors...
Abstract Numerous evidences have shown that circular RNAs (circRNAs) play a key role in regulating the pathogenesis of cancer. However, mechanism circRNAs urothelial carcinoma bladder (UCB) remains largely unclear. In this study, we found circFAM114A2 was significantly downregulated both UCB tissue specimens and cell lines, expression level highly correlated with pathological TNM stage grade. Functionally, overexpression dramatically inhibited migration, invasion proliferation cells vitro,...
BACKGROUND: Insight into motivating factors and barriers for blood donation, especially young people underrepresented minorities, is important to donor recruitment retention. We surveyed donors at a new collection facility based on large, ethnically diverse university campus. STUDY DESIGN AND METHODS: Individuals who had donated or attempted donate the during first 17 months of its operation were invited by e‐mail respond an anonymous, Web‐based questionnaire. Respondents asked provide...
Vitamin E intake has been implicated in reduction of bladder cancer risk. However, the mechanisms remain elusive. Here we reported that δ-tocotrienol (δ-T3), one vitamin isomers, possessed most potent cytotoxic capacity against human cells, compared with other isomers. δ-T3 inhibited cell proliferation and colonogenicity through induction G1 phase arrest apoptosis. Western blotting assay revealed increased expression levels cycle inhibitors (p21, p27), pro-apoptotic protein (Bax) suppressed...
Permeabilities of various trace elements (TEs) through the blood–follicle barrier (BFB) play an important role in oocyte development. However, it has not been comprehensively described as well its involved biological pathways. Our study aimed to construct a distribution model concerned TEs and explore their related We finally included total 168 women from cohort vitro fertilization-embryo transfer conducted two reproductive centers Beijing City Shandong Province, China. The concentrations 35...
To understand the prevalence and transmission of carbapenem-resistant Klebsiella pneumoniae (CRKP) in ICU patients Zhejiang Province, China, determined genetic phenotypic characteristics these CRKP strains.A total 202 from eight tertiary hospitals were recruited 55 non-duplicate strains collected during July August 2017. These subjected to determination MICs, carriage carbapenemase genes tet(A) variants, PFGE, MLST virulence potential using G. mellonella larvae infection model.A recovered 42...
Abstract Context Obesity management prior to infertility treatment remains a challenge. To date, results from randomized clinical trials involving weight loss by lifestyle interventions have shown no evidence of improved live birth rate. Objective This work aimed determine whether pharmacologic weight-loss intervention before in vitro fertilization and embryo transfer (IVF-ET) can improve rate among overweight or obese women. Methods We conducted randomized, double-blinded,...
Docetaxel (DTX) is the most widely prescribed first-line chemotherapy for advanced prostate cancer (PCa). Unfortunately, DTX resistance invariably emerges, leading to worse prognosis of PCa. Growing evidence has shown that circRNAs had complex spatiotemporal specificity during tumor development and oncogenesis. This study was designed investigate biological functions possible molecular mechanisms in PCa.circRNAs established DTX-resistant DU145 cell line were identified by RNA sequencing....
Abstract A multi-center survey on sharp injuries (SIs) among hospital-based healthcare workers (HCWs) in seven provinces of China between August and December 2011 was performed. In each province, HCWs from at least 30 hospitals were surveyed by completing a SI report form adapted the EPINet. The who declared SIs during period interviewed local infection control practitioners. included 361 206,711 HCWs, most whom nurses (47.5%) or doctors (28.4%). previous month, 17,506 incidents 13,110...
Abstract Background To compare the perioperative outcomes of transperitoneal laparoscopic (TLA), retroperitoneal (RLA), and robot-assisted (RATLA) adrenalectomy for adrenal tumors in our center. Methods Between April 2012 February 2018, 241 minimally invasive adrenalectomies were performed. Cases categorized based on technique. Demographic characteristics, information pathological data retrospectively collected analyzed. Results This study included 37 TLA, 117 RLA, 87 RATLA procedures. Any...
Lymph node (LN) metastasis is associated with unfavorable prognosis of bladder cancer (BCa). Although lymphangiogenesis functionally important in LN tumors, the potential mechanism BCa remains unclear. Here, we clarified a regulatory circRNA-mediated and based on next-generation sequencing data. We revealed that circDHTKD1 was positively significantly upregulated BCa. By analyzing co-expression patterns differentially expressed mRNAs, identified facilitated by upregulating CXCL5....
Abstract Background The burden of healthcare-associated infections (HAIs) and the spread antimicrobial resistance can be potentially preventable through comprehensive infection prevention control (IPC) programs. However, information on current state IPC implementation is rare in China. Methods A cross-sectional study was conducted Zhejiang province, China, from April to June 2021. nosocomial quality improvement center (NICQI) cooperated with 11 municipal NICQI centers introduce purpose this...
The adverse effect of ambient PM2.5 exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort 141,040 cycles to evaluate the VEP using in vitro fertilization and embryo transfer platform high-resolution data China. first investigated association between 1 week before after date VEP. average concentrations 2 weeks were approximately 47 μg/m3. pooled results revealed...