A5101474134- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Reproductive Health and Technologies
- Pelvic floor disorders treatments
- Ectopic Pregnancy Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Gynecological conditions and treatments
- Sexual Differentiation and Disorders
- Air Quality and Health Impacts
- Pregnancy-related medical research
- Cytokine Signaling Pathways and Interactions
- Hormonal and reproductive studies
- Reproductive tract infections research
- Uterine Myomas and Treatments
- Climate Change and Geoengineering
- Gestational Diabetes Research and Management
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- Sperm and Testicular Function
- Pregnancy and preeclampsia studies
- Endometrial and Cervical Cancer Treatments
Third Affiliated Hospital of Zhengzhou University
2021-2025
Zhengzhou Children's Hospital
2020-2022
Zhengzhou University
2011-2022
Background One potential cause of implantation failure is abnormal endometrial receptivity, and how to objectively evaluate receptivity has been a matter great concern. Endometrial analysis (ERA), next-generation sequencing-based test that assesses gene expression, may be valuable in predicting but whether ERA improves pregnancy outcomes patients with recurrent (RIF) currently controversial. The purpose this study was investigate the effect on RIF. Methods We performed retrospective cohort...
The adverse effect of ambient PM2.5 exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort 141,040 cycles to evaluate the VEP using in vitro fertilization and embryo transfer platform high-resolution data China. first investigated association between 1 week before after date VEP. average concentrations 2 weeks were approximately 47 μg/m3. pooled results revealed...
The use of frozen embryo transfer (FET) cycles has dramatically risen. optimal endometrial preparation method for women undergoing FET is utmost importance to provide the chances pregnancy. For patients with abnormal ovulation in particular, there have been few studies on protocols; notably, most these focus only clinical pregnancy rate or live birth (LBR) and pay little attention regimen's safety offspring. It was a retrospective cohort study. First cycle single blastocyst from whole...
With the increasing use of frozen embryo transfer (FET), best endometrial preparation protocol is continuously being discussed. The hormone replacement therapy (HRT) cycle and letrozole-induced ovulation (L-OI) are available protocols for patients with abnormal ovulation. Previous comparisons two have focused on pregnancy outcomes, less attention to perinatal population heterogeneity was large; thus, convincing conclusions about which more appropriate could not be drawn.We performed a...
Objective To explore whether elevated anti-Müllerian hormone (AMH) levels affect the rate of preterm birth (PTB) among PCOS patients with different BMIs. Methods In this retrospective cohort study, who had undergone IVF/ICSI from January 2017 to December 2019 were included for potential evaluation. A total 2368 singleton live births included. According BMI, all divided into two groups: BMI<24 kg/m 2 and BMI≥24 . total, 1339 a grouped according their serum AMH levels: ① <2.71...
Unlike poor ovarian response, despite being predicted to be normal responders based on their reserve markers, many patients respond suboptimally stimulation. Although we can improve the number of retrieved oocytes by increasing recombinant FSH dose and adding LH, effect suboptimal response cumulative live birth rate (CLBR) offspring safety is unclear. This study focuses unexpected during ovulation induction, its causes outcomes are analysed for first time with a large amount data used...
Purpose The aim of this study was to determine whether a 60-day weight reduction intervention prior in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and higher loss ratio effectively improved perinatal outcomes for infertile overweight or obese women. Methods This retrospective cohort conducted at university-affiliated fertility center. Two thousand three hundred eighty-one women who underwent did not undergo IVF/ICSI between February 27, 2017 November 11, 2020 were...
<title>Abstract</title> Young female patients with cancer are likely to become sub-fertile or infertile even if they ultimately overcome through various therapies. Cancer immunotherapy has recently emerged as a promising novel therapy against cancers high malignancy and lethality, but it is unclear whether affects fertility. This study employed MCA205 cell-allotransplanted B6 mice model investigate two popular immunotherapies—PD-1 monoclonal antibody (PD-1) whole cell vaccine (WCV)...
To explore the cumulative outcomes and influencing factors of patients with discrepancies between age Anti-Müllerian hormone (AMH) levels in early follicular phase prolonged protocol.A total 1282 cycles in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) assisted pregnancy protocol Reproductive Medicine Center Third Affiliated Hospital Zhengzhou University from September 2015 to December 2020 were retrospectively analyzed. They divided into young low-AMH group (n=1076) older...
Abstract Background Due to the high risk of complications in fresh cycle transfer among expected ovarian response patients, most choose frozen-thawed embryo (FET). There is currently few researches on whether FET outcomes patients with regular menstrual cycles are similar those normal response. Therefore, our objective explore and compare pregnancy maternal neonatal natural between based antral follicle count (AFC). Methods This retrospective cohort study included 5082 women undergoing...
Objective The purpose of this study was to evaluate the cumulative live birth rate (CLBR) mild stimulation and conventional for low-prognosis population undergoing PPOS protocols. Methods This a retrospective cohort study. We included women with low prognosis. All underwent protocols, starting gonadotropin (Gn) dose 150 IU or 300 IU. primary outcome measure CLBR. secondary measures were number oocytes retrieved, 2PN available embryos. Results In total, 171 1810 met criteria. PSM model,...
Objective To investigate the effect of assisted reproductive technology (ART) on early growth placenta and fetus in mice. Methods Experimental mice were divided into three groups: female mate naturally with male (SC group); fertilized vitro, zygotes vitro cultured (IVC (IVF group). Placentas fetal rats groups collected day 10.5, 14.5 18.5 (early, middle late gestation pregnancy, respectively), pregnancy rate abortion calculated respectively. Results In (E10.5), IVC group IVF...
Abstract Objective: To investigate when is the appropriate time interval between hysteroscopic polypectomy and start of FET cycles Design: Retrospective cohort study. Setting: Academic center. Patient(s): All patients diagnosed with endometrial polyps undergoing before FET. Intervention(s): Hysteroscopic polypectomy. MainOutcomeMeasure(s): Patients were divided into four groups based on Demographics, baseline characteristics, pregnancy outcomes after compared among groups. A total 1703 met...
Abstract Objective High expression of VEGF in ovarian tissue, serum and follicular fluid PCOS women is involved the physiological pathogenesis processes PCOS. Our objective was to investigate effect sRAGE on EGF-like growth factor granulosa cells. Methods We collected cells patients who underwent vitro fertilization (IVF). Then treatment with different concentrations sRAGE. Levels VEGF, AREG, BTC EREG mRNA were examined by quantitative RT-PCR. The protein levels measured ELISA. Results...
Abstract Objective: To evaluate the effectiveness of highly purified human menopausal gonadotropins (hp-HMG) plus recombinant follicle stimulating hormone (r-FSH) vs r-FSH luteinizing （r-LH） in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) patients。 Design : Retrospective cohort study Methods: This was a retrospective study. Among total number 3568 patients who had undergone IVF/ICSI applications, 409 eligible were included.Total units follitropin alpha preparations...
Abstract Objective High expression of VEGF in ovarian tissue, serum and follicular fluid PCOS women is involved the physiological pathogenesis processes PCOS. Our objective was to investigate effect sRAGE on EGF-like growth factor granulosa cells. Methods We collected cells patients who underwent vitro fertilization (IVF). Then treatment with different concentrations sRAGE. Levels VEGF, AREG, BTC EREG mRNA were examined by quantitative RT-PCR. The protein levels measured ELISA. Results...
Abstract Immunoglobulins are key humoral immune molecules produced and secreted by B lymphocytes at various stages of differentiation. No research has reported whether immunoglobulins present in the non-proliferative female germ cells—oocytes—and they functionally important for quality, self-protection, survival oocytes. Herein, we found that IgG was even oocytes immunodeficient mice; IgG-VDJ regions were highly variable between different oocytes, H3K27Ac bound regulated promoter region....
Abstract Purpose: The aim of this study was to determine whether a 60-day weight reduction intervention prior in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI) and higher ratio effectively improved perinatal outcomes for infertile overweight or obese women. Methods: This retrospective cohort conducted at university-affiliated fertility center.Two thousand three hundred eighty-one women who underwent did not undergo IVF/ICSI between February 27, 2017 November 11, 2020 were...
Abstract Background :In the freeze-thaw embryo transfer, use of best luteal phase support protocols is continuously being discussed, especially in natural cycles. Previous comparisons cycles focused on pregnancy outcome, with less attention to perinatal outcome. Thus, convincing conclusion about which protocol more appropriate could not be drawn. At same time, increasing drugs, benefit using these drugs also needs evidence. Methods: The clinical data 3658 mNC-FET Reproductive Center Third...
Objective To evaluate whether singleton live births achieved following in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) women with late moderate-to-severe ovarian hyperstimulation syndrome (OHSS) is associated adverse perinatal outcomes. Methods This was a single-center retrospective cohort study conducted from January 2016 to June 2021. A total of 4,012 IVF/ICSI-fresh embryo transfer cycles that were included. According the diagnosis OHSS, divided into two groups: OHSS...