A5100777018- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Developmental Biology and Gene Regulation
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Bariatric Surgery and Outcomes
- Echinoderm biology and ecology
- Reproductive Biology and Fertility
- Ectopic Pregnancy Diagnosis and Management
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Reproductive Health and Contraception
- Marine and coastal plant biology
- Ocean Acidification Effects and Responses
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Marine Biology and Environmental Chemistry
- Prenatal Substance Exposure Effects
- Cancer Risks and Factors
- Musculoskeletal pain and rehabilitation
- MicroRNA in disease regulation
- Cancer-related gene regulation
Beijing Obstetrics and Gynecology Hospital
2018-2024
Capital Medical University
2018-2024
Third Affiliated Hospital of Zhengzhou University
2019-2024
Tianjin Medical University
2018-2022
Tianjin First Center Hospital
2018-2022
Dongguan People’s Hospital
2022
Sichuan University
2021
West China Second University Hospital of Sichuan University
2021
Zhujiang Hospital
2021
Southern Medical University
2021
We report the sequence and analysis of 814-megabase genome sea urchin Strongylocentrotus purpuratus , a model for developmental systems biology. The sequencing strategy combined whole-genome shotgun bacterial artificial chromosome (BAC) sequences. This use BAC clones, aided by pooling strategy, overcame difficulties associated with high heterozygosity genome. encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside deuterostomes....
Women with gestational diabetes mellitus (GDM) have different gut microbiota in late pregnancy compared to women without GDM. It remains unclear whether alterations of can be identified prior the diagnosis This study characterized dynamic changes from first trimester (T1) second (T2) and evaluated their relationship later development Compared control group (n = 103), GDM 31) exhibited distinct dynamics microbiota, evidenced by taxonomic, functional, structural shifts T1 T2. Linear...
Two major signaling centers have been shown to control patterning of sea urchin embryos. Canonical Wnt in vegetal blastomeres and Nodal presumptive oral ectoderm are necessary sufficient initiate along the primary secondary axes, respectively. Here we define characterize a third center, animal pole domain(APD), which contains neurogenic ectoderm, can oppose signaling. The regulatory influence APD is normally restricted region, but operate most cells embryo because, absence Nodal, expands...
Anterior signaling centers are essential to specify and pattern the early anterior neuroectoderm (ANE) of many deuterostome embryos. In sea urchin embryo ANE is restricted end late blastula-stage where it forms a simple neural territory consisting several types neurons, as well apical tuft. Here, we show that during development, separates into inner outer regulatory domains expressing cardinal transcriptional regulators, FoxQ2 Six3, respectively. drives this patterning process, which...
Maternal smoking during pregnancy is a major cause of intrauterine growth restriction and childhood obesity, but only few studies have examined the association cessation before with fetal growth. We this in prospective cohort study Japan.Our included children born between 1991 2006 their mothers. Using questionnaire, maternal status was recorded at pregnancy. The anthropometric data were collected medical check-up age 3 years. Multiple linear logistic regression models used for analysis...
Abstract Background Gestational diabetes mellitus (GDM) and excessive body weight are two key risk factors for adverse perinatal outcomes. However, it is not clear whether restricted gestational gain (GWG) favorable to reduce the pregnancy neonatal outcomes in women with GDM. Therefore, this study aimed assess association of GWG after an oral glucose tolerance test maternal Methods This prospective cohort assessed (OGTT) 3126 GDM, adjusted age, pre-pregnancy mass index, height, gravidity,...
To assess whether recurrent gestational diabetes mellitus (GDM) and newly diagnosed GDM share similar risk factors.The study recruited a cohort of 10,151 multipara women with singleton pregnancy who delivered between 2016 2019 in Beijing, China. The prevalence associated factors were analyzed without prior history.Eight hundred seventy-five (8.6%) had diagnosis during previous pregnancies. pre-gestational 48.34% (423/875) 7.89% (69/875) if the pregnancies, as compared to 16.00% (1484/9276)...
Partitioning ectoderm precisely into neurogenic and non-neurogenic regions is an essential step for neurogenesis of almost all bilaterian embryos. Although it widely accepted that antagonism between BMP its inhibitors primarily sets up the border these two types ectoderm, unclear how such extracellular, diffusible molecules create a sharp precise at single-cell level. Here, we show Fez, zinc finger protein, functions as intracellular factor attenuating signaling specifically within region...
During organ development, local changes in gene expression govern morphogenesis and cell fate. We have generated a microanatomical atlas of epithelial embryonic salivary glands. The mouse submandibular gland first appears as single mass cells surrounded by mesenchyme, it undergoes rapid branching to form complex secretory with acini connected an extensive ductal system. Using laser capture microdissection, we collected samples from 14 distinct locations at days 12.5, 13.5, 14, 15,...
During embryogenesis the sea urchin early pluteus larva differentiates 40-50 neurons marked by expression of pan-neural marker synaptotagmin B (SynB) that are distributed along ciliary band, in apical plate and pharyngeal endoderm, 4-6 serotonergic confined to plate. Development all has been shown depend on function Six3. Using a combination molecular screens tests gene morpholino-mediated knockdown, we identified SoxC Brn1/2/4, which sequentially neurogenic regulatory pathway also required...
Background: Smoking during pregnancy is related to fetal constraint and accelerated postnatal growth. However, the pathways between these factors have not been clarified. Pathway analyses that link can help us better understand mechanisms involved in this association. Therefore, study aimed examine maternal smoking growth infancy.Methods: Participants were singletons born 1993 2006 rural Japan. The outcome was change weight z-score birth 3 years of age. Pathways from other (such as body mass...
The influencing factors of gestational diabetes mellitus (GDM) in the polycystic ovary syndrome (PCOS) patients remain unclear, we aimed to investigate risk GDM with PCOS, provide reliable evidence for prevention and treatment PCOS patients.PCOS treated our hospital from January 1, 2019 October 31, 2020 were included. personal clinical details no analyzed. Logistic regressions performed analyze occurrence GDM.A total 196 included, incidence was 23.98%. There significant differences age, body...
To understand how the maternally determined animal-vegetal polarity of sea urchin embryo is established, we have begun to examine regulatory apparatus gene encoding Strongylocentrotus purpuratus hatching enzyme (SpHE). Previous studies shown that pattern SpHE mRNA accumulation reflects developmental axis in transcription strongly upregulated during early cleavage more animal blastomeres, but not those around specified vegetal pole 16-cell [Reynolds et al., Development 114, 769-786 (1992)]....
<b><i>Objective:</i></b> Timing of gestational weight gain (GWG) may influence perinatal outcomes differently. This study aimed to find associations latent GWG patterns with risk large for age (LGA) in women overweight or obesity. <b><i>Methods:</i></b> A total 4,438 obesity were included the analyses. Latent trajectories associated LGA identified by trajectory analysis. GWG, and early pregnancy factors compared between these groups....
Polycystic ovary syndrome (PCOS) has been consistently associated with subsequent gestational diabetes mellitus (GDM). Women PCOS showed a high prevalence of obesity, which raises the question regarding role obesity or pe ser in development GDM. In this study we conducted 2-phase to compare risk GDM and its early pregnancy metabolic factors women without PCOS, stratified by pre-pregnancy body mass index (BMI).A design was used study. The initial phase included 566 age- BMI-matched singleton...
Abstract Background Polycystic ovarian syndrome (PCOS) is a strong risk factor for gestational diabetes (GDM). However, the association between features of PCOS during early pregnancy and GDM not clearly characterized. In this prospective cohort study, we seek to identify early‐pregnancy factors in women. Methods Between 2011 2013, 248 women with were followed from their first prenatal visit delivery. Multiple metabolic evaluated GDM. Results Among subjects, 75 (30.2%) developed Single...
Aims Early identification of gestational diabetes mellitus (GDM) aims to reduce the risk adverse maternal and perinatal outcomes. Currently, no acknowledged biomarker has proven clinically useful for accurate prediction GDM. In this study, we tested whether serum putrescine level changed in first trimester could improve Methods This study is a nested case-control conducted Beijing Obstetrics Gynecology Hospital. We examined at 8-12 weeks pregnancy 47 women with GDM age- body mass index...