A5019550792- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Neurobiology and Insect Physiology Research
- Ocean Acidification Effects and Responses
- Virus-based gene therapy research
- Cephalopods and Marine Biology
- Marine Invertebrate Physiology and Ecology
- Insect and Pesticide Research
- RNA and protein synthesis mechanisms
- Malaria Research and Control
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Viral Infectious Diseases and Gene Expression in Insects
- Diet and metabolism studies
- Entomopathogenic Microorganisms in Pest Control
- Insect Utilization and Effects
- Lipid metabolism and biosynthesis
- Clostridium difficile and Clostridium perfringens research
- Cannabis and Cannabinoid Research
- Biochemical Acid Research Studies
- Hormonal Regulation and Hypertension
- Computational Drug Discovery Methods
- Marine and coastal plant biology
- Enzyme function and inhibition
- Eicosanoids and Hypertension Pharmacology
University of British Columbia
2023
Duke University
2006-2009
University of Wisconsin–Madison
1993-2007
The Graduate Center, CUNY
1997-2007
National Institute of Dental and Craniofacial Research
2006
National Institutes of Health
2006
Stazione Zoologica Anton Dohrn
2006
Baylor College of Medicine
2006
California Institute of Technology
2006
University of California, Davis
1998-2002
We report the sequence and analysis of 814-megabase genome sea urchin Strongylocentrotus purpuratus , a model for developmental systems biology. The sequencing strategy combined whole-genome shotgun bacterial artificial chromosome (BAC) sequences. This use BAC clones, aided by pooling strategy, overcame difficulties associated with high heterozygosity genome. encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside deuterostomes....
Carboxylesterases are essential enzymes in the hydrolysis and detoxification of numerous pharmaceuticals pesticides. They vital mediating organophosphate toxicity activating many prodrugs such as chemotherapeutic agent CPT-11. It is therefore important to study catalytic mechanism responsible for carboxylesterase-induced hydrolysis, which can be accomplished through use potent selective inhibitors. Trifluoromethyl ketone (TFK)-containing compounds most esterase inhibitors described date. The...
ABSTRACT Kinetic analyses of infectivity loss during thermal inactivation reovirus particles revealed substantial differences between virions and infectious subvirion (ISVPs), as well the ISVPs reoviruses type 1 Lang (T1L) 3 Dearing (T3D). The difference in T1L T3D was attributed to major surface protein μ1 by genetic with reassortant viruses recoated cores. Irreversible conformational changes ISVP-bound were shown accompany inactivation. approximated first-order kinetics over a range...
The 144-kDa lambda2 protein is a structural component of mammalian reovirus particles and contains the guanylyltransferase activity involved in adding 5' caps to mRNAs. After incubation T3D core at 52 degrees C, became sensitive partial protease degradation. Sequential treatments with heat chymotrypsin caused degradation C-terminal portion lambda2, leaving 120K core-associated fragment. four other proteins cores--lambda1, lambda3, mu2, sigma2--were not affected by treatment. Purified cores...
Cannabis sativa L. is widely used for fiber, medicinal, and other purposes, many cultivars exist, yielding varying proportions of cannabinoids terpenes. There considerable interest in characterizing genomes transcriptomes C. sativa. Alternative splicing (AS) a fundamental aspect gene expression that results multiple types mRNAs produced by differential splicing. Transcriptome-wide identification AS events drug-type has not been reported. Here, we identified using transcriptome dataset...