A5004764228- Gut microbiota and health
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Peanut Plant Research Studies
- Clostridium difficile and Clostridium perfringens research
- Metabolism, Diabetes, and Cancer
- Plant-Microbe Interactions and Immunity
- Legume Nitrogen Fixing Symbiosis
- Metabolomics and Mass Spectrometry Studies
- Ocular Diseases and Behçet’s Syndrome
- Acupuncture Treatment Research Studies
- Cancer Research and Treatments
- Pharmacological Effects of Natural Compounds
- Colorectal Cancer Screening and Detection
- Birth, Development, and Health
- Inflammatory Bowel Disease
- Indoor Air Quality and Microbial Exposure
- Neurological Disease Mechanisms and Treatments
- Dental Health and Care Utilization
- Healthcare and Venom Research
- Animal Nutrition and Physiology
- Helicobacter pylori-related gastroenterology studies
- Fish Biology and Ecology Studies
- Reproductive System and Pregnancy
- Oral microbiology and periodontitis research
Tongji University
2020-2024
Shanghai Tenth People's Hospital
2020-2024
Qingdao University
2018-2024
Novartis (China)
2024
Hunan Agricultural University
2021-2023
Fujian Medical University
2021-2023
Sinotech Genomics (China)
2018-2022
Tobacco Research Institute
2010-2022
Beijing University of Chinese Medicine
2022
Shanghai Institute of Hematology
2020
The assessment and characterization of the gut microbiome has become a focus research in area human autoimmune diseases. Ankylosing spondylitis is an inflammatory disease evidence showed that ankylosing may be microbiome-driven disease. To investigate relationship between spondylitis, quantitative metagenomics study based on deep shotgun sequencing was performed, using microbial DNA from 211 Chinese individuals. A total 23,709 genes 12 metagenomic species were shown to differentially...
Abstract The human microbiome is an integral component of the body and a co-determinant several health conditions 1,2 . However, extent to which interpersonal relations shape individual genetic makeup its transmission within across populations remains largely unknown 3,4 Here, capitalizing on more than 9,700 metagenomes computational strain-level profiling, we detected extensive bacterial strain sharing individuals (more 10 million instances) with distinct mother-to-infant, intra-household...
Behcet's disease (BD) is a recalcitrant, multisystemic inflammatory that can lead to irreversible blindness. Microbial agents have been considered contribute the pathogenesis of this disease, but underlying mechanisms remain unclear. In study, we investigated association gut microbiome composition with BD as well its possible roles in development disease. Fecal and saliva samples were collected from 32 active patients 74 healthy controls. DNA extracted fecal was subjected metagenomic...
Given that only a subset of patients with colorectal cancer (CRC) benefit from immune checkpoint therapy, efforts are ongoing to identify markers predict immunotherapeutic response. Increasing evidence suggests microbes influence the efficacy therapies. Fusobacterium nucleatum induces different responses in CRC microsatellite-instability (MSI) statuses. Here, we investigated effect F. on anti-PD-L1 therapy CRC. We found high levels correlate improved therapeutic PD-1 blockade Additionally,...
Abstract Chinese Rice Wine (CRW) is a common alcoholic beverage in China. To investigate the influence of microbial composition on quality CRW, high throughput sequencing was performed for 110 wine samples bacterial 16S rRNA gene and fungal Internal Transcribed Spacer II (ITS2). Bioinformatic analyses demonstrated that yeast starter final correlated with taxonomic composition, which exemplified by our finding spoilage resulted from proportion genus Lactobacillus . Subsequently, based...
Women with gestational diabetes mellitus (GDM) have different gut microbiota in late pregnancy compared to women without GDM. It remains unclear whether alterations of can be identified prior the diagnosis This study characterized dynamic changes from first trimester (T1) second (T2) and evaluated their relationship later development Compared control group (n = 103), GDM 31) exhibited distinct dynamics microbiota, evidenced by taxonomic, functional, structural shifts T1 T2. Linear...
Globally, dental caries is the most prevalent chronic oral disease and affects roughly half of all children. The aim this report was to use metagenomic analyses investigate relationship between microbiome in preschool A total 25 preschoolers, aged 3 5 years old with severe early childhood (ECC), 19 age-matched, caries-free children as controls were recruited. Saliva samples collected from participants subjected analyses, whereby microbial communities investigated. revealed substantial...
Abstract Background While the physical and chemical properties of airborne particulate matter (PM) have been extensively studied, their associated microbiome remains largely unexplored. Here, we performed a longitudinal metagenomic survey 106 samples PM 2.5 10 in Beijing over period 6 months 2012 2013, including those from several historically severe smog events. Results We observed that composition functional potential were conserved between , although considerable temporal variations...
Background Vogt-Koyanagi-Harada (VKH) disease is a multisystemic autoimmune disorder characterized by granulomatous panuveitis. Gut microbiome has been considered to play role in the pathogenesis of this but whether alternation gut was involved unclear. This study set up identify abnormalities composition VKH disease.Results Depleted butyrate-producing bacteria, lactate-producing bacteria and methanogens as well enriched Gram-negative were identified active patients, patients Mix enterotype...
Abstract Intestinal microbiota plays a crucial role in immune development and disease progression mammals from birth onwards. The gastrointestinal tract of newborn is rapidly colonized by microbes with tremendous biomass diversity. Understanding how this complex segmental communities evolves different sites over time has great biological significance medical implications. However, most previous reports examining intestinal have focused on fecal samples, strategy that overlooks the spatial...
Arsenic contamination is a worldwide public health problem, and the effect of arsenic on male reproduction has been extensively studied; however, data biotoxicity in terms female are more scarce. In this study, human-cell-animal translational strategy was applied to explore exposure ovarian steroidogenesis its potential mechanism. We conducted 1:1 propensity score matched case-control study involving 127 diminished reserve (DOR) cases healthy controls. The follicular fluid levels 21 metal...
Increasing evidence has shown that gut microbes play an important role in the reproductive endocrine system and development of polycystic ovary syndrome (PCOS). However, whether environmental factors are involved these microbiota alterations seldom been studied. In this study, we aimed to explore crucial imbalanced on abnormal ovarian follicle induced by Cu. A 1:1 matched case-control study with 181 PCOS patients controls was conducted using a propensity score matching protocol. Information...