A5089764681- Gut microbiota and health
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Air Quality and Health Impacts
- Birth, Development, and Health
- Biochemical Analysis and Sensing Techniques
- Advanced Chemical Sensor Technologies
- Liver Disease Diagnosis and Treatment
- Climate Change and Health Impacts
- Olfactory and Sensory Function Studies
- Clostridium difficile and Clostridium perfringens research
- Oral microbiology and periodontitis research
- Dietary Effects on Health
- Sleep and related disorders
- Antioxidant Activity and Oxidative Stress
- Gestational Diabetes Research and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Nutritional Studies and Diet
- Bone health and osteoporosis research
- Folate and B Vitamins Research
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Fatty Acid Research and Health
Fudan University
2020-2025
Zhongshan Hospital
2020-2025
State Key Laboratory of Genetic Engineering
2020-2024
Northeastern University
2024
Xi'an Institute of Optics and Precision Mechanics
2022-2023
Chinese Academy of Sciences
2022-2023
Huazhong University of Science and Technology
2019-2021
Ministry of Ecology and Environment
2021
Zhejiang University
2015
Abstract Background COVID-19 is an infectious disease characterized by multiple respiratory and extrapulmonary manifestations, including gastrointestinal symptoms. Although recent studies have linked gut microbiota to diseases such as influenza, little known about the role of in pathophysiology. Methods To better understand host-gut interactions COVID-19, we microbial community barrier function using metagenomic metaproteomic approaches 63 patients 8 non-infected controls. Both...
Though gut microbiome disturbance may be involved in the etiology of gestational diabetes mellitus (GDM), data on microbiome's dynamic change during pregnancy and associations with glucose metabolism are still inadequate. In this prospective study comprising 120 pairs GDM patients matched pregnant controls, a decrease diversity microbial species changes community composition advancing gestation found while no such trends observed patients. Multivariable analysis identifies 10 GDM-related...
Abstract Background Circulating levels of amino acids were associated with blood pressure (BP) in observational studies. However, the causation such associations has been hypothesized but is difficult to prove human Here, we aimed use two-sample Mendelian randomization analyses evaluate potential causal circulating BP and risk hypertension. Methods We generated genetic instruments for nine by conducting meta-analyses genome-wide association study (GWAS) UK Biobank participants metabolomic...
Abstract STUDY QUESTION Is physical activity or sedentary time associated with semen quality parameters? SUMMARY ANSWER Among healthy men screened as potential sperm donors, higher self-reported was increased progressive and total motility. WHAT IS KNOWN ALREADY Despite the claimed beneficial effect of moderate on quality, results from epidemiological studies have been inconclusive. Previous were mostly conducted among endurance athletes male partners couples who sought infertility...
Integrative analysis of high-quality metagenomics and metabolomics data from fecal samples provides novel clues for the mechanism underpinning gut microbe-human interactions. However, regarding influence collection methods on both are sparse. Six (the gold standard [GS] [i.e., immediate freezing at -80°C with no solution], 95% ethanol, RNAlater, OMNIgene Gut, occult blood test [FOBT] cards, Microlution) were used to collect 88 eight healthy volunteers whole-genome shotgun sequencing (WGSS)...
Due to climate change, the frequency and intensity of heat waves other extreme weather events are rapidly increasing. Compared general population, pregnant women fetuses increasingly vulnerable effects temperatures associated with occurrence adverse birth outcomes, including preterm (PTB). However, its risk is currently uncertain. The objective research examine effect ambient temperature on PTB in women. This study included 6,850 from Tongji-Shuangliu Birth Cohort. Meteorological data for...
A prospective cohort study was conducted to investigate sleep status during the early and second trimester of pregnancy in pregnant women on adverse birth outcome, such as preterm birth, low weight small for gestational age. Multivariable logistic regression models were used analyze association with outcomes generated odds ratio 95% confidence interval. 5,418 included analysis. In multivariable model, compared 7.1–8 h/night, ≤ 7 h/night increases risk (OR: 1.43, CI: 1.12,1.85), decreased who...
Emerging evidence has highlighted that olfactory dysfunction, a common feature of aging, is increasingly linked to cognitive decline in older adults. However, research on the underlying mechanism, particularly role nasal microbiome, remains limited. In this study, we investigated associations between function, and cognition among 510 adults with an average age 77.9 years. Olfactory function was assessed using brief Chinese Smell Identification Test, assessments were conducted via Mini-Mental...
Abstract The interplay among cigarette smoking status, oral microbiota, and cardiometabolic health is poorly understood. We aimed to examine the association of status with microbiota assess identified microbial features risk factors in a Chinese population. This study included 587 participants within Central China Cohort, including 111 smokers 476 non-smokers, their was profiled by 16S rRNA sequencing. Both alpha- beta-diversity were distinct between non-smokers ( p < 0.05). With...
Recurrent oral ulcer (ROU) is a prevalent and painful disorder with implications beyond physical symptoms, impacting quality of life necessitating comprehensive management. Understanding the interplays between dietary factors, microbiota, ROU crucial for developing targeted interventions to improve systemic health. Dietary behaviors plant-based diet indices including healthful index (hPDI) were measured based on validated food frequency questionnaire. Saliva microbial features profiled using...
Background Contemporary risk assessment in patients with coronary atherosclerotic disease (CAD) often relies on invasive angiography. However, we aimed to explore the potential of metabolomic biomarkers reflecting residual CAD after moderate lipid‐lowering therapy. Methods and Results We analyzed serum profile among 2560 newly diagnosed undergoing therapy, through nuclear magnetic resonance spectroscopy quantified 175 metabolites, predominantly lipoproteins their components. severity was...
Heterologous vaccine schedules have been recommended to provide superior immunity and protection against emergent SARS-CoV-2 variants of concern. We aimed evaluate the safety, immunogenicity, efficacy an mRNA COVID-19 RQ3013 compared with adenoviral vectored Ad5-nCoV protein subunit ZF2001 as fourth dose in adults primed three doses inactivated vaccines China.
The associations between visceral adipose tissue (VAT) and bone mineral density (BMD) or fracture have been controversial the causality of remains to be assessed. This study aimed explore VAT^ (predicted value VAT mass) with BMD risk in men women, examine their potential causation by two-sample Mendelian randomization (MR) analyses.UK Biobank is a large, population-based prospective cohort that recruited more than 500,000 participants aged 40-69 United Kingdom from 2006 2010. In this study,...
Alterations in the gut microbiota have been observed patients with pulmonary hypertension (PH), though whether roles of PH at different altitudes are same is unknown. This study aims to evaluate associations microbiome highlanders and lowlanders.PH controls were recruited from those who permanently live on Tibetan plateau (highlanders) or plains (lowlanders), underwent transthoracic echocardiography close their altitude residence (at 5070 m for versus6 lowlanders). The was profiled using...